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Sulfalene (Longum)

Long-acting plasma-bound sulfonamide used for respiratory and urinary tract infections and also for malaria.

Also Known As:

Longum; Kelfizine; Pharmacia Brand of Sulfalene; Sulfametopyrazine; Sulphalene; Sulphametopyrazine; Sulfamethopyrazine; Sulfamethoxypyrazine; Sulfapyrazinmethoxine; Benzenesulfonamide, 4-amino-N-(3-methoxypyrazinyl)-

Networked: 229 relevant articles (16 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fujimori, Minoru: 8 articles (09/2010 - 03/2002)
2.	Taniguchi, Shun'ichiro: 6 articles (09/2010 - 03/2002)
3.	Amano, Jun: 5 articles (09/2010 - 03/2002)
4.	Sasaki, Takayuki: 5 articles (09/2010 - 11/2002)
5.	Ha, Nam Joo: 4 articles (11/2015 - 12/2005)
6.	Zeng, Zhongming: 4 articles (05/2013 - 08/2010)
7.	Huang, Zhen: 4 articles (05/2013 - 08/2010)
8.	Zeng, Weiseng: 4 articles (05/2013 - 08/2010)
9.	Yu, Zhijian: 4 articles (05/2013 - 08/2010)
10.	Iwatsuki, Keiji: 4 articles (01/2011 - 03/2007)

Related Diseases

1.	Falciparum Malaria (Plasmodium falciparum Malaria) 03/01/1978 - "These findings suggest that acetylator phenotype does not influence the therapeutic response of individuals infected with falciparum malaria to sulfalene or to the combination of sulfalene and pyrimethamine. " 03/01/1978 - "The influence of acetylator phenotype on the response to sulfalene in individuals with chloroquine-resistant falciparum malaria." 11/01/1971 - "Treatment of falciparum malaria with sulfalene and trimethoprim." 07/01/1971 - "Treatment of acute falciparum malaria from Vietnam with trimethoprim and sulfalene." 07/28/1969 - "Sulfalene and trimethoprim in acute falciparum malaria."
2.	Infection 06/01/2012 - "To investigate the cell viability of Bifidobacterium longum 5(1A) in fermented milks and to study its immunostimulating and protective capacity against Salmonella enterica ssp. enterica serovar Typhimurium infection in mice. " 01/01/2015 - "Bifidobacterium longum MM-2 (MM-2), a very safe bacterium in humans, was isolated from healthy humans and its protective effect against IFV infection in a murine model shown. " 05/01/2013 - "longum expressing the VP1 protein might successfully elicit a specific immune response against EV71 infection." 05/01/2013 - "longum that could be used to develop an oral vaccine against EV71 infection. " 01/01/2011 - "longum can be used to treat virus infection still remains elusive. "
3.	Diarrhea 01/01/2008 - "To determine the efficacy of a combination of Bifidobacterium longum PL03, Lactobacillus rhamnosus KL53A and Lactobacillus plantarum PL02 for the prevention of antibiotic-associated diarrhea in children. " 05/01/2006 - "A multicenter, parallel-group, randomized, double-blind, active-controlled clinical trial, involving 169 outpatients at 9 centers, was conducted to assess the efficacy of a fixed bacterium combination of Lactobacillus gasseri and Bifidobacterium longum in the therapy of acute diarrhea. " 01/01/2008 - "Bifidobacterium longum PL03, Lactobacillus rhamnosus KL53A, and Lactobacillus plantarum PL02 in the prevention of antibiotic-associated diarrhea in children: a randomized controlled pilot trial." 01/01/2014 - "Acute diarrhea is the most studied disease for which bifidobacteria are applied with great success, Bifidobacterium longum and Bifidobacterium breve being the most applied species. " 05/01/2006 - "Oral therapy with a fixed combination of Lactobacillus gasseri and Bifidobacterium longum shortens the duration and decreases the severity of acute self-limiting diarrhea in adults comparable to an effective mono-bacterium medicinal product. "
4.	Seasonal Allergic Rhinitis (Hay Fever) 03/01/2007 - "Clinical efficacy of probiotic Bifidobacterium longum for the treatment of symptoms of Japanese cedar pollen allergy in subjects evaluated in an environmental exposure unit." 01/01/2007 - "We have previously reported the results of a randomized, double-blind, placebo-controlled trial that found the intake of yogurt supplemented with a probiotic strain, Bifidobacterium longum BB536, alleviates symptoms and affects blood parameters in individuals with Japanese cedar pollinosis (JCPsis) during the pollen season. " 11/01/2006 - "The present study investigated the effects of probiotic strain Bifidobacterium longum BB536 in the treatment of Japanese cedar pollinosis (JCPsis). " 01/01/2006 - "This study tested the effect of a yogurt supplemented with a probiotic strain Bifidobacterium longum BB536 in the treatment of Japanese cedar pollinosis (JCPsis). " 10/01/2007 - "Influence of Bifidobacterium longum BB536 intake on faecal microbiota in individuals with Japanese cedar pollinosis during the pollen season."
5.	Malaria 03/01/1978 - "When sulfalene was administered during malaria, this difference was no longer apparent. " 03/01/1978 - "Following the administration of sulfalene before infection with malaria, a significant difference in half-life of non-acetylated sulfalene and percent acetylation of sulfalene in plasma was observed between rapid and slow acetylators. " 01/01/2007 - "Sulphadoxine/sulphalene-pyrimethamine (SP) was adopted in Kenya as first line therapeutic for uncomplicated malaria in 1998. " 02/01/1975 - "Host failure in treatment of malaria with sulfalene and pyrimethamine." 07/01/1968 - "[Comparative study of the association of sulfalene and pyrimethamine and of sulfalene alone in mass chemoprophylaxis of malaria]."

Related Drugs and Biologics

1.	Pyrimethamine (Daraprim)
2.	artesunate
3.	Amodiaquine (Camoquin)
4.	Trimethoprim (Proloprim)
5.	lumefantrine
6.	artemether
7.	Carbon Monoxide
8.	Sulfamethoxazole
9.	Chloroquine (Aralen)
10.	Tetracycline (Achromycin)

Related Therapies and Procedures

1.	Oral Administration
2.	Reducing Diet
3.	Aftercare (After-Treatment)
4.	Immunomodulation
5.	Bioreactors