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Sulfadoxine (Sulformethoxine)

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A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.

Also Known As:

Sulformethoxine; Fanasil; Ro 4-4393; Roche Brand of Sulfadoxine; Sulformetoxine; Sulphormetoxin; Sulphorthodimethoxine; Ro 4 4393; Ro 44393; Sulfadoxine Roche Brand; Sulforthomidine; Benzenesulfonamide, 4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)-

Networked: 292 relevant articles (45 outcomes, 44 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Sowunmi, A: 8 articles (04/2006 - 04/2000)
2.	Adedeji, A A: 6 articles (04/2006 - 04/2000)
3.	Fateye, B A: 5 articles (04/2006 - 10/2003)
4.	Fehintola, F A: 5 articles (11/2005 - 04/2000)
5.	Happi, T C: 4 articles (04/2006 - 01/2004)
6.	Mberu, E K: 4 articles (11/2002 - 03/2000)
7.	Watkins, W M: 4 articles (11/2002 - 03/2000)
8.	Nzila, A M: 4 articles (11/2002 - 03/2000)
9.	Winstanley, P A: 3 articles (02/2011 - 04/2000)
10.	Roper, Cally: 3 articles (06/2008 - 04/2003)

Related Diseases

1.	Falciparum Malaria (Plasmodium falciparum Malaria) 01/01/2004 - "The in vivo therapeutic efficacy of sulfadoxine- pyrimethmanine (SP) was assessed in a clinical setting involving 77 falciparum malaria patients diagnosed at Alamata Sector Laboratory, Southern Tigray in Sept--Nov. 2001. " 12/15/2007 - "The method was applied for the assay of sulfadoxine and its metabolite N-acetyl sulfadoxine in plasma from Plasmodium falciparum malaria patients. " 12/15/2007 - "High-performance liquid chromatographic assay for the determination of sulfadoxine and N-acetyl sulfadoxine in plasma from patients infected with sensitive and resistant Plasmodium falciparum malaria." 10/01/2006 - "Therapeutic efficacy of quinine plus sulfadoxine-pyremethamine for the treatment of uncomplicated falciparum malaria in Bangladesh." 05/01/2006 - "To compare the efficacy of sulfadoxine-pyremethamine (SP)+chloroquine (CQ) combination treatment against falciparum malaria with SP treatment alone. "
2.	Malaria 09/01/1988 - "In contrast to these findings, in malaria patients, plasma concentrations of active and total sulfadoxine were even higher in nonresponders as compared to the subjects who could be successfully cured. " 04/01/2007 - "To assess whether traditional birth attendants, drug-shop vendors, community reproductive health workers and adolescent peer mobilizers can administer intermittent preventive treatment (IPT) with sulfadoxine-pyremethamine to pregnant women, and reach those most at risk of malaria and increase access and compliance to it. " 12/09/1997 - "An important class of drugs in malaria treatment is the sulfone/sulfonamide group, of which sulfadoxine is the most commonly used. " 09/01/1988 - "Plasma concentrations of sulfadoxine in healthy and malaria infected Thai subjects." 05/11/2004 - "In this area of very restricted use of pyrimethamine-sulfadoxine, the drug appears to be still sufficiently effective in the treatment of malaria. "
3.	Infection 01/01/1976 - "Effect of sulfadoxine on transmission of Vibrio cholerae infection among family contacts of cholera patients in Calcutta." 03/01/2003 - "High prevalence of quintuple mutant dhps/dhfr genes in Plasmodium falciparum infections seven years after introduction of sulfadoxine and pyrimethamine as first line treatment in Malawi." 01/01/1988 - "All 39 children treated with pyrimethamine (target dose 1.2 mg/kg) and sulfadoxine (target dose 24 mg/kg) were cleared of infection, while the following had recurrences on days 14, 21, and 28: 1 of 39, 2 of 38, and 2 of 36. " 09/01/1987 - "The results of this study in Thailand indicate that the early response of falciparum infections to a single dose of pyrimethamine-sulfadoxine is influenced by the developmental stages of the parasite present at the time of treatment. " 10/01/2003 - "The clinical features of the primary Plasmodium falciparum infections in 25 children, and of the recrudescent infections that emerged after pyrimethamine-sulfadoxine (PS) treatment of the children had failed, were evaluated. "
4.	Encephalitis (Encephalitis, Rasmussen) 08/01/1999 - "[Pyrimethamine and sulfadoxine as a preventive treatment for Pneumocystis carinii and Toxoplasma encephalitis]." 05/01/1993 - "Pyrimethamine/sulfadoxine twice a week appears to be a promising regimen for prevention of toxoplasmic encephalitis, and also appears to provide protection against Pneumocystis carinii pneumonia. " 05/01/2002 - "The safety and efficacy of a fixed 25 mg pyrimethamine-500 mg sulfadoxine combination supplemented with 15 mg folinic acid twice a week as primary prophylaxis of Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis was evaluated in 106 patients infected with the human immunodeficiency virus. " 01/01/2001 - "To evaluate the safety and efficacy of a fixed 25mg pyrimethamine--500mg sulfadoxine combination plus 15mg folinic acid given twice weekly for the prevention of relapses of Pneumocystis carinii pneumonia (PCP) and primary episodes of toxoplasmic encephalitis. " 05/01/1993 - "Efficacy of pyrimethamine/sulfadoxine in the prevention of toxoplasmic encephalitis relapses and Pneumocystis carinii pneumonia in HIV-infected patients."
5.	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 01/01/1997 - "The medical records of 157 patients taking pyrimethamine-sulfadoxine for Pneumocystis carinii pneumonia prophylaxis were reviewed for assessment of safety and tolerance. " 01/01/1997 - "The safety of pyrimethamine and sulfadoxine for the prevention of Pneumocystis carinii pneumonia." 07/01/1994 - "Pyrimethamine/sulfadoxine for prevention of Pneumocystis carinii pneumonia in patients infected with the human immunodeficiency virus." 05/01/1993 - "Forty-nine of the 56 patients did not have a history of Pneumocystis carinii pneumonia and did not receive antiparasitic prophylaxis other than pyrimethamine/sulfadoxine; two of them (4 %) developed pneumocystosis. " 05/01/1993 - "Pyrimethamine/sulfadoxine twice a week appears to be a promising regimen for prevention of toxoplasmic encephalitis, and also appears to provide protection against Pneumocystis carinii pneumonia. "

Related Drugs and Biologics

1.	Pyrimethamine (Daraprim)
2.	Chloroquine (Aralen)
3.	sulfadoxine-pyrimethamine (Fansidar)
4.	Mefloquine (Lariam)
5.	Quinine (Quinson)
6.	Amodiaquine (Camoquin)
7.	artesunate
8.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)
9.	Leucovorin (Folinic Acid)
10.	Dapsone

Related Therapies and Procedures

1.	Chemoprevention
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)
4.	Transplantation (Transplant Recipients)
5.	Transplants (Transplant)