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Sucralfate (Carafate)

A basic aluminum complex of sulfated sucrose.

Also Known As:

Carafate; Antepsin; Basic Aluminum Sucrose Sulfate; Ulcerban; Ulcogant; Ulsanic; Sulfate, Aluminum Sucrose; Aluminum Sucrose Sulfate; Aluminum, hexadeca-mu-hydroxytetracosahydroxy(mu8-(1,3,4,6-tetra-O-sulfo-beta-D-fructofuranosyl alpha-D-glucopyranoside tetrakis(hydrogen sulfato)(8-)))hexadeca-

Networked: 898 relevant articles (195 outcomes, 242 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Oakes, R: 6 articles (01/2011 - 01/2000)
2.	Roalfe, A: 6 articles (01/2011 - 01/2000)
3.	Soo, S: 6 articles (01/2006 - 01/2000)
4.	Harris, A: 6 articles (01/2006 - 01/2000)
5.	Innes, M: 6 articles (01/2006 - 01/2000)
6.	Forman, D: 6 articles (01/2006 - 01/2000)
7.	Moayyedi, P: 6 articles (01/2006 - 01/2000)
8.	Deeks, J: 6 articles (01/2006 - 01/2000)
9.	Delaney, B: 6 articles (01/2006 - 01/2000)
10.	Wilson, S: 5 articles (01/2006 - 01/2000)

Related Diseases

1.	Duodenal Ulcer (Curling's Ulcer) 06/09/1989 - "Analysis of procedurally correct cases demonstrated that sucralfate suspension was significantly more effective in healing duodenal ulcers than placebo at two, four, and eight weeks. " 01/01/1987 - "The results indicate that sucralfate is significantly more effective than placebo in the prevention of recurrence of duodenal ulcer disease." 01/01/1991 - "Sucralfate is superior to placebo and comparable to H2 antagonists in the prevention of duodenal ulcer recurrence." 02/01/1989 - "However, sucralfate is superior to antacid in the ongoing maintenance therapy of chronic duodenal ulcer in childhood. " 11/02/1992 - "It is concluded that 2 g sucralfate at bedtime is effective in preventing recurrence of duodenal ulcer symptoms."
2.	Ulcer 12/01/2005 - "After the intervetion, there was a significant improvement in hand-hygiene practices (p<0.001) among healthcare providers and increased use of sucralfate (p=0.05) for stress ulcer prophylaxis. " 02/01/2001 - "The drug given orally in doses of 200 and 600 mg/kg twice daily for five days, showed significant protection against all the above experimental ulcer models and the results were comparable with those elicited by sucralfate (SF, 250 mg/kg, p.o., BD x 5 days). " 07/01/1994 - "The potential advantages of sucralfate lie in the better quality of ulcer healing associated with longer duration of remission." 06/09/1989 - "It is concluded that 1 g sucralfate twice daily is more effective than a placebo and is safe for the maintenance treatment of duodenal and pyloric ulcer disease." 01/01/1995 - "The mucosal-coating drug sucralfate has not been found effective in preventing NSAID ulcers. "
3.	Peptic Ulcer (Peptic Ulcers) 06/01/1985 - "Sucralfate is an effective medication in preventing the recurrence of peptic ulcer. " 01/01/1981 - "Its therapeutic efficacy, combined with the fact that it is well tolerated and free of serious systemic effects, enhances sucralfate's therapeutic clinical usefulness in the treatment of peptic ulcer disease." 01/01/1987 - "International studies have shown sucralfate to be a safe and effective short- and long-term treatment for patients with peptic ulcer. " 01/01/1989 - "[A comparative evaluation of the efficacy of sucralfate and H2-histamine blockaders in treating peptic ulcer]." 08/29/1988 - "[Multicenter clinical studies of the effectiveness of sucralfate in the treatment of peptic ulcer]."
4.	Stomach Ulcer (Gastric Ulcer) 03/01/1984 - "Controlled therapeutic trials have demonstrated that sucralfate 1g 4 times daily is effective in increasing the rate of healing of duodenal and gastric ulcer over a period of 4 to 8 weeks. " 08/08/1991 - "The results suggest that 2 g sucralfate twice daily is as effective in the healing of gastric ulcer as 1 g sucralfate q.i.d." 08/08/1991 - "Clinical efficacy of sucralfate in the treatment of gastric ulcer." 07/01/1990 - "Maintenance treatment with sucralfate delayed symptoms of gastric ulcer recurrence. " 01/01/2007 - "The purpose of the investigation was to study the effects of sucralfate on the biochemical composition as well as the anti-radicals and antioxidative activity (ARA; AOA) of the gastric supra-epithelial mucosal layer (GSEML) in patients with Helicobacter pylori (HP)-associated gastric ulcer (GU). "
5.	Hemorrhage 02/01/1996 - "The cost per bleeding episode averted was highly dependent on the risk of hemorrhage and, to a lesser degree, on the efficacy of sucralfate prophylaxis, ranging from a cost per bleeding episode averted of $103,725 for low-risk patients to cost savings for very high-risk patients. " 09/28/1987 - "Despite a significantly greater severity of illness in the sucralfate group (p less than 0.01), no significant difference in overt or occult bleeding between the groups could be demonstrated. " 09/01/1994 - "Other recommendations such as the use of sucralfate, which is effective in prevention of bleeding without clear side effects, are probably worth instituting based on existing evidence. " 01/01/1990 - "These actions are the pathophysiologic basis of the efficacy of sucralfate in the prevention of stress bleeding. " 08/08/1991 - "These studies demonstrate that sucralfate is capable not only of prevention or attenuation of acute damage when administered prior to damaging agents, but is also capable of arresting the sequence of events that produces hemorrhage in the previously inflamed or damaged stomach."

Related Drugs and Biologics

1.	Cimetidine (Biomet)
2.	Ranitidine (Zantac)
3.	Sucralfate (Carafate)
4.	Antacids
5.	Omeprazole (Esomeprazole)
6.	Pirenzepine
7.	Bismuth
8.	bismuth tripotassium dicitrate (bismuth subcitrate)
9.	Histamine (Histamine Dihydrochloride)
10.	Misoprostol (Cytotec)

Related Therapies and Procedures

1.	Enema (Enemas)
2.	Drug Therapy (Chemotherapy)
3.	Radiotherapy
4.	Sclerotherapy
5.	Artificial Respiration (Mechanical Ventilation)