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Streptozocin (Streptozotocin)

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An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.

Also Known As:

Streptozotocin; Zanosar; 2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose; Streptozotocine; Teva Brand of Streptozocin; Streptozocin Teva Brand; D-Glucose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-

Networked: 6346 relevant articles (303 outcomes, 981 trials/studies)

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Drug Context: Research Results

Experts

1.	Singh, Nirmal: 17 articles (08/2015 - 03/2008)
2.	Pari, Leelavinothan: 13 articles (05/2015 - 01/2004)
3.	Yokozawa, Takako: 13 articles (03/2015 - 09/2002)
4.	Chopra, Kanwaljit: 13 articles (12/2014 - 04/2004)
5.	Zhang, Li: 13 articles (01/2014 - 01/2006)
6.	Tschöpe, Carsten: 13 articles (06/2009 - 03/2003)
7.	Lee, Myung G: 12 articles (10/2010 - 09/2004)
8.	Adeghate, Ernest: 12 articles (08/2010 - 10/2002)
9.	Schultheiss, Heinz-Peter: 12 articles (06/2009 - 07/2003)
10.	Adeghate, E: 12 articles (04/2006 - 01/2000)

Related Diseases

1.	Hyperglycemia 11/01/2012 - "sumatrana aqueous extract is beneficial for improvement of hyperglycemia by increasing gene expression of liver Slc2a2 and reducing expression of G6Pase and PCK1 genes in streptozotocin-induced diabetic rats." 01/01/2012 - "Further, we have investigated the therapeutic efficacy of ES cell-derived IPCs to correct hyperglycemia in syngeneic streptozotocin (STZ)-treated diabetic mice. " 09/01/1987 - "Of 22 immunomodulatory substances screened 12 were effective in modulating the course of hyperglycemia following low dose streptozotocin treatment. " 06/01/2010 - "In this study, we investigated the protective effects of fermented ginseng (FG) on hyperglycemia induced by streptozotocin (STZ) in Sprague Dawley rats. " 05/14/2014 - "Efficacy of ginseng adventitious root extract on hyperglycemia in streptozotocin-induced diabetic rats."
2.	Diabetic Nephropathies (Diabetic Nephropathy) 04/01/2014 - "A marked decrease of klotho expression was observed in the kidney of streptozotocin-induced diabetic rats (STZ rats) showing diabetic nephropathy. " 05/01/2014 - "Sequoyitol ameliorates diabetic nephropathy in diabetic rats induced with a high-fat diet and a low dose of streptozotocin." 06/01/2010 - "This study investigates whether prolonged administration of PTX (40 mg/kg, per oral) is effective in streptozotocin-induced diabetic nephropathy. " 01/01/2009 - "Gallotannin ameliorates the development of streptozotocin-induced diabetic nephropathy by preventing the activation of PARP." 06/01/2015 - "The present study was designed to elucidate the therapeutic mechanism of BBR in a type 2 diabetic nephropathy rat model induced by a high-fat diet and low-dose streptozotocin injection. "
3.	Diabetes Mellitus 10/15/2015 - "Renal autoregulation is impaired in early (1 wk) diabetes mellitus (DM) induced by streptozotocin, but effective in established DM (4 wk). " 06/01/2014 - "Extract of Moringa oleifera leaves ameliorates streptozotocin-induced Diabetes mellitus in adult rats." 07/01/2013 - "We attempted a method wherein bladder function can be improved in streptozocin-induced diabetes mellitus. " 02/01/2015 - "In the present study, we established a rat model of diabetes mellitus using high-fat diet and streptozotocin (STZ). " 08/05/2014 - "In our present study, we investigated the anti-inflammatory and antioxidant properties of N-adamantyl-4-methylthiazol-2-amine (KHG26693), a new thiazole derivative, in a streptozotocin (STZ)-induced model of diabetes mellitus. "
4.	Body Weight (Weight, Body) 01/01/2010 - "In the present study, we aimed at verifying whether such modulatory effects of PAMAM G4 (0.5 micromol/kg of body weight daily for 60 days) may contribute to improved respiration in heart and liver mitochondria from streptozotocin-diabetic rats. " 10/01/2012 - "The present study evaluated the antihyperglycaemic effect of its aqueous extract administered orally (daily) in three different doses (100, 300, 500 mg/kg body weight) for a period of 30 d to streptozotocin (STZ)-induced diabetic rats. " 07/01/2012 - "In the present study, the antioxidative potential of Trigonella foenum-graecum seed powder was assessed in high fat diet and low dose streptozotocin (35 mg/kg body weight) induced type II diabetic rats. " 04/01/2003 - "Thus, by the administration of different doses of streptozotocin (STZ) (0, 25, 30, or 35 mg/kg body weight, intravenous) at the onset of pregnancy in rats, the present study sought an appropriate animal model for this pathology. " 01/01/2002 - "These were obtained from 22 Syrian hamsters injected with streptozotocin (50 mg/kg body weight., intraperitoneal route) 90 days before the study began. "
5.	Hyperalgesia 03/06/2007 - "Eight weeks streptozotocin-diabetic rats developed neuropathy which was evident from significant reduction in motor nerve conduction velocity (MNCV), nerve blood flow (NBF) and increased thermal hyperalgesia. " 11/01/2014 - "In this study, the temporal course of neuropathic symptoms was investigated in diabetic rats induced by streptozotocin and evaluated by nerve conduction velocity and behavioral assays, including the von Frey test for mechanical allodynia and the hot plate test for hyperalgesia. " 09/01/2014 - "In the present study, we found that a proportion of streptozotocin (STZ)-treated rats suffered from mechanical allodynia and thermal hyperalgesia for a long-lasting time. " 05/01/2011 - "Hence, the present study was designed as a 24-week longitudinal investigation of the extent to which the level of glycemic control in the streptozotocin (STZ)-diabetic rat model of Type 1 diabetes affects the development of mechanical allodynia and opioid hyposensitivity in these animals. " 03/01/2008 - "In the present study, using streptozotocin (STZ)-induced diabetic rats that displayed tactile allodynia, we found several morphological changes of activated microglia in the dorsal horn. "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Glucose (Dextrose)
3.	Doxorubicin (Adriamycin)
4.	Blood Glucose (Blood Sugar)
5.	Fluorouracil (Carac)
6.	Niacinamide (Nicotinamide)
7.	Curcumin
8.	Enzymes
9.	Taurine
10.	Quercetin

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Transplantation (Transplant Recipients)
3.	Oral Administration
4.	Intraperitoneal Injections
5.	Intravenous Injections