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Streptomycin (Streptomycin Sulfate)

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An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.

Also Known As:

Streptomycin Sulfate; CEPA Brand of Streptomycin Sulfate; Clariana Brand of Streptomycin Sulfate; Estreptomicina CEPA; Estreptomicina Clariana; Estreptomicina Normon; Fatol Brand of Streptomycin Sulfate; Grünenthal Brand of Streptomycin Sulfate; Normon Brand of Streptomycin Sulfate; Panpharma Brand of Streptomycin Sulfate; Sanavita Brand of Streptomycin Sulfate; Strepto-Fatol; Strepto-Hefa; Streptomycin Grünenthal; Streptomycin Sulfate (2:3) Salt; Streptomycin Sulphate; Streptomycine Panpharma; Wernigerode Brand of Streptomycin Sulfate; Strepto Fatol; Strepto Hefa; D-Streptamine, O-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl-(1-4)-N,N'-bis(aminoiminomethyl)-

Networked: 5192 relevant articles (194 outcomes, 283 trials/studies)

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Drug Context: Research Results

Carbohydrates: 4088
- Glycosides: 547
  - Aminoglycosides: 1446
    - Streptomycin: 5192

Experts

1.	Hardt, Wolf-Dietrich: 15 articles (12/2015 - 05/2003)
2.	Stecher, Bärbel: 9 articles (01/2012 - 02/2004)
3.	Kremer, Marcus: 7 articles (01/2011 - 05/2003)
4.	Finlay, B Brett: 6 articles (01/2015 - 01/2008)
5.	Jarlier, Vincent: 6 articles (02/2012 - 02/2007)
6.	Hapfelmeier, Siegfried: 6 articles (01/2006 - 05/2003)
7.	Grosset, Jacques H: 5 articles (06/2015 - 10/2010)
8.	Bäumler, Andreas J: 5 articles (01/2013 - 09/2007)
9.	Ji, Baohong: 5 articles (02/2012 - 02/2007)
10.	Chauffour, Aurélie: 5 articles (02/2012 - 02/2007)

Related Diseases

1.	Infection 01/01/1978 - "The following conclusions may be derived from the results thus obtained: 1. Most of the fully attenuated streptomycin-independent revertants failed to provide sufficient protection against wild-strain infection, following one single intraperitoneal immunization. " 03/01/2010 - "Important pharmacological properties of streptomycin and sulfonamide drugs are determined to evaluate the efficacy for CNS targeting in clinical treatment of MSSA and and MRSA infections. " 01/01/1950 - "Experimental basis for prediction of therapeutic efficacy of streptomycin in infections caused by gram negative bacilli." 12/12/1970 - "The long-acting sulphonamides alone gave a cure rate of 55% while streptomycin alone eradicated 43% of the infections. " 06/01/2011 - "Streptomycin should be the first choice for Yersinia pestis infection, but its optimal dose needed further study. "
2.	Tuberculosis (Tuberculoses) 09/01/2015 - "Good outcomes (81% 5 year survival) were documented when PAS was first used with streptomycin, yet results of PAS with remaining potentially effective drugs for the treatment of XDR tuberculosis are poor (mortality 30-90%). " 09/01/1993 - "Soon after its discovery, streptomycin sulfate was found to be beneficial in the treatment of tuberculosis. " 01/01/1953 - "[Atypical tuberculosis of the neuraxis in a 4-year-old child; rapid cure with intramuscular streptomycin]." 07/01/1975 - "In 51 children with tuberculosis of the hip, overall end results were better, and the range of motion was improved when irrigation-suction with Streptomycin was included in the regimen of surgical management." 02/01/2007 - "Waksman (1888-1973) Nobel Prize in 1952 for the discovery of streptomycin, the first antibiotic effective against tuberculosis."
3.	Pulmonary Tuberculosis 07/01/1950 - "[Limits of the efficacy of PAS in primary pulmonary tuberculosis and indications for associated PAS-streptomycin treatment; research and considerations on 185 cases]." 01/01/2010 - "This paved the way for the first randomized control trial of streptomycin in pulmonary tuberculosis carried out in 1946 by MRC of the UK. " 04/01/2004 - "The 1948 report of the British Medical Research Council's randomized trial of streptomycin for pulmonary tuberculosis is widely regarded as marking the beginning of the modern history of controlled clinical trials. " 05/01/1957 - "[Studies on the clinical pictures of pulmonary tuberculosis patients and the bacteriostatic effects of tubercle bacillus in the resected specimens, with special reference to streptomycin-resistance. " 02/01/1955 - "[Studies on the extremely streptomycin resistant variants of tubercle bacilli in the pulmonary tuberculosis patients]."
4.	Meningeal Tuberculosis (Tuberculous Meningitis) 09/02/1950 - "[Relapse and recurrence of tuberculous meningitis in a patient treated successfully with streptomycin]." 01/01/1955 - "[Results in clinically cured tuberculous meningitis after streptomycin treatment with special reference to pneumoencephalogram, electroencephalogram and development test (Bühler-Hetzer)]." 07/01/1952 - "[Six new cases of tuberculous meningitis cured by streptomycin therapy]." 01/01/1953 - "[Anatomic and clinical sequelae of a case of tuberculous meningitis cured by streptomycin]." 03/01/1952 - "[The distant future of meningeal tuberculosis cured by streptomycin]."
5.	Endocarditis 08/01/1992 - " Resistance to streptomycin in 1 patient may have been secondary to treatment with aminoglucosides for endocarditis. " 05/01/1987 - "Using a model of experimental infective endocarditis, we infected rabbits with a control streptomycin-susceptible strain, with an intermediately streptomycin-resistant strain (MIC, 1,000 micrograms/ml), and with a highly streptomycin-resistant strain (MIC, greater than 32,000 micrograms/ml). " 11/01/1986 - "We used two strains of streptomycin-susceptible enterococci (MIC, 64 and 128 micrograms of streptomycin per ml, respectively) isolated from patients with infective endocarditis. " 06/01/1984 - "Treatment of streptomycin-susceptible and streptomycin-resistant enterococcal endocarditis." 02/01/1982 - "faecalis endocarditis due to strains all designated resistant to streptomycin by MIC, except in rabbits infected with a strain, which showed partial susceptibility to the drug by IC50. "

Related Drugs and Biologics

1.	Rifampin (Rifampicin)
2.	Isoniazid (Ftivazide)
3.	Penicillins (Penicillin)
4.	Anti-Bacterial Agents (Antibiotics)
5.	Doxycycline (Vibramycin)
6.	Ethambutol (Myambutol)
7.	Gentamicins (Gentamicin)
8.	Tetracycline (Achromycin)
9.	Vancomycin
10.	Pyrazinamide

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Injections
3.	Aftercare (After-Treatment)
4.	Combination Drug Therapy (Combination Chemotherapy)
5.	Ventriculoperitoneal Shunt