Streptodornase and Streptokinase

A mixture of the enzymes (streptokinase and streptodornase) produced by hemolytic streptococci. It is used topically on surface lesions and by instillation in closed body cavities to remove clotted blood or fibrinous or purulent accumulations. It is also used as a skin test antigen in evaluating generalized cell-mediated immunodeficiency. (Dorland, 27th ed) EC 3.-.

Also Known As:

Networked: 133 relevant articles (4 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mendoza, R D: 1 article (01/2008)
2.	Vera-García, M E: 1 article (01/2008)
3.	Franco-Molina, M A: 1 article (01/2008)
4.	Zapata-Benavides, P: 1 article (01/2008)
5.	Rodríguez-Padilla, C: 1 article (01/2008)
6.	Castillo-Tello, P: 1 article (01/2008)
7.	Garza, R G: 1 article (01/2008)
8.	García de la Fuente, A: 1 article (01/2008)
9.	Mendoza-Gamboa, E: 1 article (01/2008)
10.	Támez-Guerra, R S: 1 article (01/2008)

Related Diseases

1.	Pressure Ulcer (Bedsore) 01/01/1985 - "In a single-blind, randomized trial, the efficacy of topical streptokinase-streptodornase (Varidase) solution was compared with that of zinc oxide on necrotic pressure ulcers in 28 patients. " 07/01/1996 - "In a randomised, double-blind, controlled trial, a comparison was made of the relative efficacy of using streptokinase/streptodornase (Varidase) in a hydrogel (KY Jelly) or the hydrogel alone in the debridement of Grade IV pressure sores. "
2.	Mumps 06/01/1977 - "We investigated the skin test responses to PHA, mumps, candida, and varidase (SK-SD) and the PHA-induced lymphocyte transformation in patients with malignant neoplasms. " 06/23/1980 - "This study has been carried out in vivo by means of skin tests (BCG, PPD, Candida, Varidase, CCB, Mumps, BNCB) and in vitro with lymphocyte blastization in the presence of PHA and dependent antibody cytotoxicity. " 08/01/1978 - "The skin tests with Varidase, Candidine, Mumps antigen and DNCB were not significantly different at onset and in remission. " 01/01/1983 - "After intracutaneous injection of five recall antigens (Candida, mumps, PPD, tricophyton and varidase) nineteen subjects showed no response (anergy), seven showed only a weak reaction (relative anergy), and thirty-seven a normal reaction. " 11/01/1975 - "It was found, that the in vitro lymphocyte reactivity of 54 CD patients after stimulation with a cocktail of antigens (varidase, trichophyton, candida, mumps, and PPD) was significantly depressed when compared with the response of 20 simultaneously cultured healthy controls (p less than 0-001) or a group of 54 separately cultured healthy controls, matched for age and sex (p less than 0-001). "
3.	Empyema 07/03/1954 - "[Streptokinase and streptodornase therapy of empyema and postoperative hemothorax]." 04/01/1954 - "[Treatment of hemothorax-empyema with streptokinase and streptodornase]." 05/11/1953 - "[Decortication of the lung and resection of the cavity in the treatment of chronic empyema; review of cases treated by other methods and use of streptodornase and streptokinase in coagulated hemothorax]." 01/01/2000 - "The in vitro efficacy of varidase versus streptokinase or urokinase for liquefying thick purulent exudative material from loculated empyema." 01/01/2000 - "Liquefaction of thick pleural exudates from rabbits with empyema can be achieved with Varidase but not with streptokinase or urokinase."
4.	Suppuration 01/01/1983 - "With Varidase it appears that pus and debris are more easily removed, and that at the same time the agent is well tolerated." 01/01/1983 - "The results of treatment with the two enzyme preparations showed Varidase to be statistically significantly (p less than 0.05) better as an adjuvant in removing pus and debris from the ulcers. " 01/01/1986 - "In conclusion, this study shows that Varidase effectively cleans the urinary bladder from pus, fibrin, necrotic tissue and blood clots." 06/01/2006 - "However, the combination of streptokinase and streptodornase and rhDNase have been shown to liquefy pus in vitro. " 01/01/1983 - "38 patients with traumatic ulcers containing pus and debris were treated for two weeks with either Trypure or Varidase in a random fashion. "
5.	Urinary Tract Infections (Urinary Tract Infection) 10/01/1966 - "Clinical studies on combined therapy with Varidase oral in urinary tract infections]."

Related Drugs and Biologics

1.	Streptokinase
2.	Deoxyribonuclease I (Nickase)
3.	Hydrogel
4.	Zinc Oxide
5.	K-Y jelly
6.	Antigens
7.	Dinitrochlorobenzene (DNCB)
8.	Urokinase-Type Plasminogen Activator (Urokinase)
9.	Tuberculin (PPD)
10.	Trypsin

Related Therapies and Procedures

1.	Debridement
2.	Drug Therapy (Chemotherapy)
3.	Enzyme Therapy
4.	Sutures (Suture)
5.	Splenectomy