Stomatitis

10/01/2010 - "A significant reduction in the incidence of radiation-induced oral mucositis by Palifermin has been demonstrated. "
10/01/2014 - "Assessment of the hamster cheek pouch as a model for radiation-induced oral mucositis, and evaluation of the protective effects of keratinocyte growth factor using this model."
03/01/2014 - "The aim of this study was to evaluate the efficacy of palifermin, an N-terminal truncated version of endogenous keratinocyte growth factor, in the control of oral mucositis during antiblastic therapy. "
10/01/2014 - "Additionally, palifermin when administered on days 1, 2 and 3 after irradiation (40 Gy) reduced the severity of oral mucositis. "
05/01/2009 - "Palifermin (recombinant human keratinocyte growth factor) reduces the severity of oral mucositis with HSCT. "

01/01/2003 - "The present clinical trial is to date by far the largest study assessing the effectiveness of topical GM-CSF and it is the first study comparing the efficacy of topical GM-CSF in the 'prophylactic' setting, i.e., with the aim to prevent the chemoradiotherapy-induced oral mucositis, with that in the 'curative' treatment, i.e., the therapy for established oral mucositis. "
11/01/2001 - "The topical application of GM-CSF resulted in a significantly shorter duration and quicker resolution of oral mucositis, as compared to AA including both, pretreatment plus treatment periods (5.3+/-2.5 versus 8.1+/-1.5 days; P=0.0008) as well as the necessary duration of treatment needed until complete remission of lesions (2.8+/-0.7 versus 6.3+/-1.1 days; P<0.0001). "
10/01/2002 - "Oral mucositis tended to be less severe in the GM-CSF group (p = 0.072). "
03/01/2002 - "Published literature assessing the use of GM-CSF to treat or prevent oral mucositis was analyzed. "
03/01/2002 - "To evaluate the effect of granulocyte macrophage-colony stimulating factor (GM-CSF) in patients with oral mucositis. "

11/01/1991 - "Only one patient given allopurinol mouthwash (AMW group), however, suffered from Grade 1 stomatitis. "
11/01/1991 - "Six of 23 patients which were not given allopurinol mouthwash (control group) developed stomatitis of Grade 1 (three patients), Grade 3 (two), or Grade 4 (one). "
04/15/1990 - "A controlled evaluation of an allopurinol mouthwash as prophylaxis against 5-fluorouracil-induced stomatitis."
10/01/1989 - "In contrast, stomatitis was observed in only 2 of the 10 patients receiving PF therapy and 2 of the 5 VAC in the allopurinol-treated group. "
04/01/2002 - "These results suggest that allopurinol spray is markedly effective for the prevention of stomatitis induced by chemotherapy. "

10/01/2014 - "Oral mucositis was induced in 72 male golden hamsters by administration of 5-fluorouracil (60mg/kg), on days 0, 5, and 10 of the study. "
03/01/2013 - "Oral mucositis was induced in 60 male hamsters by 5-FU (60 mg/kg) on days 0, 5, and 10 of the study. "
03/01/2013 - "This study assessed the potential of topical Calendula officinalis extract on the healing of oral mucositis induced by 5-fluorouracil (5-FU) in hamsters. "
02/01/2016 - "Multivariate analyses found that the dose reduction in 5-FU or oral fluoropyrimidine, ED intake, and the prior administration of ED were each a significant factor for the preventive efficacy on oral mucositis. "
02/01/2016 - "Dose reduction of 5-fluorouracil (5-FU) or oral fluoropyrimidine was performed in the 2 patients achieving grade 3 oral mucositis and in the 3 patients achieving grade 2 oral mucositis. "

11/01/2005 - "Experimental L-glutamine agent shown effective in oral mucositis."
01/01/2014 - "Role of oral glutamine in alleviation and prevention of radiation-induced oral mucositis: A prospective randomized study."
02/01/2000 - "Oral glutamine to alleviate radiation-induced oral mucositis: a pilot randomized trial."
08/01/1998 - "This study tested whether an oral glutamine preparation could decrease the severity of oral mucositis in patients undergoing BMT. "
10/01/2013 - "These findings suggested that oral mucositis was successfully induced and treatment with l-glutamine partially reversed these conditions. "

01/01/2009 - "This study was a prospective, randomized clinical trial carried out to explore the efficacy of payayor in the prevention and relief of radiation-induced oral mucositis compared with benzydamine. "
03/01/2015 - "Efficacy of benzydamine oral rinse in prevention and management of radiation-induced oral mucositis: A double-blind placebo-controlled randomized clinical trial."
03/01/2015 - "Several studies have demonstrated positive effects of benzydamine oral rinse in prevention of radiation-induced oral mucositis. "
06/01/1989 - "Prevention of oral mucositis in radiation therapy: a controlled study with benzydamine hydrochloride rinse."
03/01/2015 - "Benzydamine oral rinse can be considered as an effective, safe and well-tolerated medication for prevention of radiation-induced oral mucositis and alleviating its symptoms."

03/01/1997 - "The resultant data from this clinical trial did not support the prestudy hypothesis that sucralfate would be beneficial for the treatment of 5FU-induced stomatitis."
02/01/1994 - "The efficacy of sucralfate suspension in the prevention of oral mucositis due to radiation therapy."
01/01/2000 - "Forty-four patients with head and neck malignancies were included in a prospective, randomized, double-blind, placebo-controlled study for evaluation of sucralfate in prevention of oral mucositis induced by radiation therapy. "
02/01/1994 - "The study was a double-blind, placebo-controlled, randomized prospective trial of a sucralfate suspension in the prevention and management of oral mucositis during radiation therapy. "
01/01/2003 - "There was no difference in the frequency or severity of oral mucositis between the sucralfate- and the placebo-treated group. "

01/01/2014 - "This study aimed at developing a novel rebamipide liquid for an effective treatment of oral mucositis. "
11/01/2014 - "These results suggest that rebamipide is effective for the treatment of oral mucositis. "
11/01/2014 - "We hope to verify the preventive and protective effects of rebamipide by conducting a prospective, randomized trial while treating oral mucositis with basic oral care and appropriate interventions provided by a multidisciplinary team."
11/01/2014 - "Daily rebamipide was administered to patients with oral mucositis as per hospital protocol to evaluate the hypothesized preventive and mucosal protective effects of rebamipide(Mucosta®). "
01/01/2015 - "Because of its pharmacological properties including anti-inflammatory activity and stimulatory effects on endogenous prostaglandin synthesis, rebamipide has been suggested as a potentially effective treatment against stomatitis. "

02/01/2012 - "As the safety of folinic acid administration and its efficacy for reducing the toxicity of MTX remain controversial, we assessed the effect of folinic acid administration after MTX treatment for GVHD prophylaxis on the incidence of oral mucositis and acute GVHD. "
09/01/1990 - "While the incidence of stomatitis and gastrointestinal toxicity were lower during leucovorin treatment, our study lacked sufficient power to establish a statistically significant difference."
03/01/1990 - "An analysis of the toxicities experienced by the patients in the two treatment groups showed that, except for significantly more stomatitis in the leucovorin arm of the study, the side effects experienced by patients treated with either regimen were comparable. "
05/01/2012 - "Folinic acid (FA) as treatment for oral mucositis toxicity was used at investigator discretion in 72 of 140. "
02/01/2012 - "Systemic folinic acid administration and mouthwash appear to be useful for reducing the incidence of severe oral mucositis in patients who have received allogeneic hematopoietic SCT using MTX as GVHD prophylaxis."

09/01/2011 - "The review of literature included 5 studies fulfilling the inclusion criteria, in which chlorhexidine was evaluated and 4 studies showed a significant preventive effect on the development or severity of oral mucositis; the remaining study showed no benefit of using chlorhexidine mouthwash when compared with the placebo group. "
11/01/2015 - "Cost-effective analysis of topical chlorhexidine in hematologic patients at risk for oral mucositis."
01/01/2011 - "New form of administering chlorhexidine for treatment of denture-induced stomatitis."
12/01/2006 - "These results do not support the use of chlorhexidine mouthwash to prevent oral mucositis."
04/01/2003 - "A significant decrease in the incidence of oral mucositis and ulceration was observed in the children who received a 0.12% chlorhexidine mouth rinse (p < 0.05 by Fisher's exact test). "

01/01/2014 - "AESN showed protective effect in both models of oral mucositis; however, the higher dose was more effective in chemotherapy induced oral mucositis. "
08/01/2001 - "Although the management of patients with other chemotherapy-related toxicities has improved in recent years, the incidence of stomatitis is increasing because of more intensive treatment and is often a dose limiting factor in chemotherapy. "
01/01/2015 - "However, none of these mouthrinses have been shown to be definitely effective in preventing chemotherapy induced oral mucositis."
10/01/2013 - "Preliminary findings indicate that OLE is effective in reducing IL-1β and TNF-α levels after chemotherapy and exert a therapeutic effect and prevent development of severe oral mucositis."
01/01/2010 - "As yet, no absolute treatment has been demonstrated to be effective for chemotherapy-induced oral mucositis. "

11/01/2013 - "Tissue-engineered oral mucosa to study radiotherapy-induced oral mucositis."
04/07/2003 - "The aim of this study was to analyse the effects of selective oral flora elimination on radiotherapy-induced oral mucositis, in a double-blind, randomised, placebo-controlled trial. "
09/01/2001 - "The role of HSV-1 in oral mucositis during head and neck radiotherapy needs additional study."
11/01/2015 - "Only 11 (27.5%) patients developed oral mucositis (OM) Grade 2 and only 4 (10%) patients OM Grade 3, no patient developed OM Grade 4. No patient discontinued radiotherapy because of OM. "
10/01/2015 - "Oral mucositis induced by radiation is an inevitable but transient side-effect of radiotherapy. "

03/01/2007 - "In this multicenter randomized study, we addressed whether cryotherapy during MTX administration is effective in the prevention of severe oral mucositis in patients undergoing myeloablative AHSCT. "
07/01/1994 - "Oral cooling (cryotherapy), an effective treatment for the prevention of 5-fluorouracil-induced stomatitis."
03/01/2007 - "The incidence of severe (grade 3-4) oral mucositis, the primary end point of the study, was comparable in patients receiving or not cryotherapy. "
02/01/2007 - "This prospective randomized study investigates whether oral cryotherapy alleviates 5FU-induced stomatitis. "
02/01/2007 - "Prevention of 5-fluorouracil-related stomatitis by oral cryotherapy: a randomized controlled study."

07/01/2012 - "Photomedicine using LLLT is very effective with intraoral and extraoral devices in the management of oral mucositis, based on several studies including randomized control studies. "
04/01/2012 - "Efficacy of low-level laser therapy (LLLT) in oral mucositis: what have we learned from randomized studies and meta-analyses?"
01/01/2016 - "This study was designed to estimate the cost-effectiveness of low-level laser therapy (LLLT) to prevent oral mucositis in HNSCC patients receiving CRT. "
11/01/2015 - "This study indicates that a combined protocol of intraoral and extraoral application of LLLT can reduce the severity of oral mucositis in pediatric patients undergoing HSCT. "
08/01/2010 - "Several studies have suggested that low-level laser therapy (LLLT) can ameliorate oral mucositis; however, the mechanisms involved are not well understood. "

02/01/2011 - "The objective of this study was to assess the efficacy of a novel visible-light therapy (VLT) device for the prevention of oral mucositis in hematopoietic stem cell transplantation (HSCT) patients. "
10/01/2014 - "This study was done to examine the incidence of oral mucositis in hematopoietic stem cell transplantation patients and to identify factors influencing oral mucositis and patient outcomes according to severity. "
01/01/2014 - "[Assessing the effectiveness of Gelclair® in the prevention and therapy of stomatitis in patients undergoing hematopoietic stem-cell transplantation: a randomized trial]."
06/01/2013 - "The purpose of this study was to determine the incidence and severity of oral mucositis and to assess the correlation of this disease with the oral health of an individual at the time of hematopoietic stem cell transplantation. "
05/01/2012 - "The objective of this study was to evaluate the effect of salivary stimulation therapies on the salivary flow, oral mucositis, and salivary cytokine levels in patients receiving allogeneic hematopoietic stem cell transplantation. "