Steroid 21-Hydroxylase (21 Hydroxylase)

An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Also Known As:
21 Hydroxylase; 21-Hydroxylase; Steroid 21 Monooxygenase; Cytochrome P-450 21-Hydroxylase; Cytochrome P-450 c21; Cytochrome P-450(c-21); Cytochrome P450c21; Progesterone 21-Hydroxylase; Steroid-21-Hydroxylase; Cytochrome P 450 21 Hydroxylase; Cytochrome P 450 CYP21; Cytochrome P 450 c21; P-450 c21, Cytochrome; Progesterone 21 Hydroxylase; Steroid 21 Hydroxylase; Cytochrome P-450 CYP21; Steroid 21-Monooxygenase; Steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)
Networked: 1330 relevant articles (11 outcomes, 81 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. New, Maria I: 24 articles (06/2014 - 02/2002)
2. Merke, Deborah P: 21 articles (08/2015 - 02/2002)
3. Krone, Nils: 12 articles (11/2013 - 06/2002)
4. Arlt, Wiebke: 11 articles (06/2014 - 06/2004)
5. Lee, Hsien-Hsiung: 11 articles (01/2014 - 01/2002)
6. Nimkarn, Saroj: 11 articles (10/2011 - 08/2006)
7. Falhammar, Henrik: 10 articles (11/2015 - 01/2007)
8. Husebye, Eystein S: 10 articles (03/2015 - 01/2004)
9. Otten, Barto J: 10 articles (02/2015 - 03/2003)
10. Concolino, Paola: 10 articles (01/2014 - 02/2006)

Related Diseases

1. Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal)
2. Addison Disease (Addison's Disease)
3. Virilism (Virilization)
4. Hypertension (High Blood Pressure)
5. Cystic Fibrosis (Mucoviscidosis)
09/01/2013 - "The protocol was standardized on a variety of known mutations, in 11 patients with cystic fibrosis (CF), Fabry's disease (FD), steroid 21-hydroxylase deficiency (21-HD), and Duchenne/Becker muscular dystrophy (DMD/BMD). "
11/01/2007 - "The protocol was standardized on a variety of known mutations, in 11 patients with cystic fibrosis (CF), Fabry's disease (FD), steroid 21-hydroxylase deficiency (21-HD) and Duchenne/Becker muscular dystrophy (DMD/BMD). "
01/01/1988 - "There is some controversy concerning the list of diseases recommended for mass screening, among them four can be discussed: congenital adrenal hyperplasia, due to 21-hydroxylase deficiency, fulfils most of the criteria, but some changes in the general screening strategy should be made to provide a result as soon as possible, and at least before the 10th day of life; cystic fibrosis, immunoreactive trypsin is a good marker of the disease but its assay needs technical adaptation for mass screening; more information are also required about the efficacy of an early management of the disease; Duchenne muscular dystrophy has a good marker for neonatal screening (creatine kinase), but no treatment exists and the possibility of genetic counselling can only be provided; hypercholesterolaemia is a frequent disease; however, the good marker and the adequate treatment remain to be defined. "
11/01/1995 - "We have determined human leucocyte antigen class I (A and B) and class II (DR) phenotypes by serological tissue typing and class II (DR and DQ) and class III (complement component C4 and 21-hydroxylase) gene polymorphisms in 274 children and young adults with cystic fibrosis, of whom 82 had evidence of chronic liver disease with portal hypertension in 49, and 146 healthy controls. "

Related Drugs and Biologics

1. Autoantibodies
2. Adrenocorticotropic Hormone (ACTH)
3. Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)
4. Cortodoxone (11 Deoxycortisol)
5. Biological Markers (Surrogate Marker)
6. Trypsin
7. Creatine Kinase (Creatine Phosphokinase)
8. 17-alpha-Hydroxyprogesterone (17 Hydroxyprogesterone)
9. Aldosterone
10. Renin

Related Therapies and Procedures

1. Adrenalectomy
2. Aftercare (After-Treatment)
3. Hysterectomy
4. Drug Therapy (Chemotherapy)
5. Arthroplasty