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Steroid 12-alpha-Hydroxylase (CYP8B1)

A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.
Also Known As:
CYP8B1; 12alpha-Hydroxylase; Cytochrome P450 8B1; Cytochrome P450 CYP8B1; Steroid 12-Hydroxylase; Steroid-12-Hydroxylase; Steroid-12-Monooxygenase; Sterol 12 alpha-Hydroxylase; 12 alpha Hydroxylase; 12 alpha-Hydroxylase, Sterol; 12alpha Hydroxylase; Steroid 12 Hydroxylase; Steroid 12 Monooxygenase; Steroid 12 alpha Hydroxylase; Sterol 12 alpha Hydroxylase; alpha-Hydroxylase, Sterol 12; 12-alpha-Hydroxylase; Steroid 12-Monooxygenase; Sterol 12-alpha-Hydroxylase; Steroid, hydrogen-donor:oxygen oxidoreductase (12-alpha-hydroxylating)
Networked: 55 relevant articles (4 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Arman, Hadi D: 3 articles (01/2022 - 12/2018)
2. Offei, Samuel D: 3 articles (01/2022 - 12/2018)
3. Yoshimoto, Francis K: 3 articles (01/2022 - 12/2018)
4. Qin, Jian: 3 articles (01/2020 - 08/2011)
5. Hayden, Michael R: 3 articles (01/2018 - 04/2015)
6. Patankar, Jay V: 3 articles (01/2018 - 04/2015)
7. Eggertsen, Gösta: 2 articles (12/2020 - 01/2016)
8. Haeusler, Rebecca A: 2 articles (01/2020 - 01/2017)
9. Chiang, John Y L: 2 articles (11/2019 - 12/2013)
10. Pathak, Preeti: 2 articles (11/2019 - 12/2013)

Related Diseases

1. Insulin Resistance
2. Body Weight (Weight, Body)
3. Obesity
4. Non-alcoholic Fatty Liver Disease
5. Cholestasis
01/30/2024 - "GE attenuated ANIT-induced hepatotoxicity and cholestasis in rats by upregulating Cyp8b1 expression to inhibit BA synthesis in the liver, while also promoting BA excretion via the intestinal-fecal route, and improving enterohepatic circulation of BAs."
10/15/2018 - "These findings suggest that the adaptive regulation of Fxr-mediated ileum-liver signaling axis on Cyp7a1/Cyp8b1 might be the potentially novel targets for amelioration or treatment of estrogen-induced cholestasis, and we expect that this study would be of great value to provide a cue for patients with estrogen-induced cholestasis."
07/14/2022 - "EE also influenced bile acid synthase Cyp7a1, Cyp8b1, and tight junctions ZO-1 and Occludin, which might be associated with EE-induced cholestasis. "
10/15/2018 - "It has been found that the depression of "ileal Fxr-Fgf15 (fibroblast growth factor 15)-hepatic Cyp7a1 pathway" in coordinated with activation of "hepatic Fxr-Shp (small heterodimer partner)-Cyp8b1 pathway" as well as up-regulation of Cyp27a1 expression synergistically promoting the hepatic biosynthesis of chenodeoxycholic acids (CDCAs) that are the potent agonists of Fxr, contribute to the Bsep up-regulation mediated the bile flow restoration to alleviate the cholestasis. "
02/01/2007 - "Consistently, hypophysectomy protects the liver against induction by EE of serum bilirubin and alkaline phosphatase, two markers of cholestasis and hepatotoxicity and modulates the effects of EE on several genes involved in bile acid homeostasis (e.g., FXR, SHP, BSEP, and Cyp8b1). "

Related Drugs and Biologics

1. Glucose (Dextrose)
2. Insulin (Novolin)
3. Estrogens (Estrogen)
4. Ceramides
5. Mechanistic Target of Rapamycin Complex 1
6. fibroblast growth factor 21
7. Bile Acids and Salts (Bile Acids)
8. Steroid 12-alpha-Hydroxylase (CYP8B1)
9. Enzymes
10. Cholesterol

Related Therapies and Procedures

1. Bariatric Surgery
2. Therapeutics
3. Hypophysectomy