Steatitis

A disease of cats and mink characterized by a marked inflammation of adipose tissue and the deposition of "ceroid" pigment in the interstices of the adipose cells. It is believed to be caused by feeding diets containing too much unsaturated fatty acid and too little vitamin E. (Merck Veterinary Manual, 5th ed; Stedman, 25th ed)

Also Known As:

Networked: 19 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Vitamin E Deficiency
2.	Muscular Diseases (Myopathy)
3.	Ectopic Pregnancy
4.	Neoplasms (Cancer)
5.	Necrosis

Experts

1.	Murata, Koichi: 2 articles (01/2015 - 01/2011)
2.	Neagari, Yasuko: 2 articles (01/2015 - 01/2011)
3.	Miura, Takamasa: 1 article (01/2015)
4.	Harada, Ken-Ichi: 1 article (01/2015)
5.	Asayama, Munehiko: 1 article (01/2015)
6.	Shirai, Makoto: 1 article (01/2015)
7.	Nishizawa, Tomoyasu: 1 article (01/2015)
8.	Deacon, A R: 1 article (07/2011)
9.	Pienaar, D J: 1 article (07/2011)
10.	Govender, D: 1 article (07/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Steatitis:

1.	microcystinIBA 01/01/2015 - "This study aimed to verify a hypothesis that the egrets and herons which died in the reservoir drink microcystin-producing cyanobacteria and microcystin involves in the cause of death as well as the symptoms of steatitis. "
2.	Vitamin EFDA LinkGeneric 01/01/2011 - "Egrets with steatitis had low blood levels of vitamin E. " 07/01/1954 - "Experimental production of steatitis yellow fat disease) in kittens fed a commercial canned cat food and prevention of the condition by vitamin E." 09/01/2003 - "These findings suggest that vitamin E deficiency may be involved in the development of anemia, myopathy, and steatitis in callitrichids; however, in some marmosets, underlying diseases such as chronic colitis may have influenced the development of anemia and impaired vitamin E status." 04/01/1992 - "Some syndromes, such as steatitis in cats, result from an increased requirement of vitamin E in diets that contain large amounts of polyunsaturated fatty acids, and these diseases will only respond to vitamin E administration. " 07/01/1986 - "Generalized steatitis associated with selenium deficiency and normal vitamin E status in a foal."
3.	CeroidIBA 12/01/1999 - "Necropsy revealed a generalized steatitis, and histology showed a necrotizing and granulomatous pansteatitis with intralesional pigment compatible with ceroid. " 12/01/1983 - "The histopathologic diagnosis was granulomatous steatitis, with fat necrosis, based on the finding of multinucleated giant cells, ceroid, and multiple foci of inflammatory cells." 07/01/1979 - "Microscopically, myopathy and steatitis were observed, together with an extensive ceroid storage. " 07/01/2011 - "Necrosis and inflammation of the adipose tissues, with characteristic ceroid accumulation within the resultant granulomata and the associated aggregation of ceroid-containing macrophages, were demonstrated histologically and were typical of steatitis. "
4.	SeleniumIBA 07/01/1986 - "Generalized steatitis associated with selenium deficiency and normal vitamin E status in a foal." 08/01/2006 - "Blood alpha-Tocopherol, selenium, and glutathione peroxidase changes and adipose tissue fatty acid changes in kittens with experimental steatitis (yellow fat disease): a comparative study between the domestic shorthaired and Siamese breed."
5.	TocopherolsFDA Link 07/01/1994 - "Steatitis, a sensitive histopathological indicator of vitamin E deficiency in animals fed on diets rich in fatty acids with three or more double bonds, was observed only in the adipose tissue of the FO groups, even in the group with the highest DL-alpha-tocopheryl acetate supplementation. "
6.	alpha-TocopherolFDA Link 08/01/2006 - "Blood alpha-Tocopherol, selenium, and glutathione peroxidase changes and adipose tissue fatty acid changes in kittens with experimental steatitis (yellow fat disease): a comparative study between the domestic shorthaired and Siamese breed."
7.	Cyclosporine (Ciclosporin)FDA LinkGeneric 12/01/2002 - "The histopathologic diagnosis was steatitis, and the dog was treated with prednisolone and cyclosporine for 2.5 years. "
8.	VitaminsIBA 06/01/1999 - "Steatitis due to vitamin E deficiency occurred in three 10-wk-old boat-billed herons (Cochlearius cochlearius) despite daily placement of a powdered vitamin supplement on the fish that was subsequently washed off by the parents. "
9.	Prednisolone (Predate)FDA LinkGeneric 12/01/2002 - "The histopathologic diagnosis was steatitis, and the dog was treated with prednisolone and cyclosporine for 2.5 years. "
10.	LipidsIBA 01/15/1974 - "Non-extractable lipids in the adipose tissues of horses and ponies affected with generalized steatitis." 01/15/1974 - "When adipose tissues of horses and ponies affected with generalized steatitis were extracted by acetone, methanol and chloroform, non-extractable lipids were found to be present, which had become insoluble as a result of peroxidation and polymerization and had acquired autofluorescent characteristics. "

Therapies and Procedures

1.	Surgical Portasystemic Shunt (Portosystemic Shunt) 10/15/1994 - "In 2 cats, chylous ascites was associated with nonneoplastic diseases: 1 cat had severe biliary cirrhosis and an extrahepatic portosystemic shunt; the other had steatitis caused by vitamin E deficiency. "
2.	Laparotomy 04/01/1994 - "In an eight-year old Galloway cow, an ectopic pregnancy with mummification of the fetus which had been assumed because of history and clinical examination of the animal was diagnosed as a "tumor of the adipose tissue" (steatitis) following exploratory laparotomy. "