Staphylococcal Infections

10/01/2020 - "Accordingly, MO-LCNPs have an application for localised Pseudomonas aeruginosa and Staphylococcus aureus infections that produce non-regiospecific lipases and for concentration-dependent antibiotics that have macromolecular (MW ~ 30 kDa) or hydrophobic (logP ~ 4) chemistries, as a triggered bolus release would be clinically efficacious for improved bacterial eradication."
12/01/2018 - "The promising results obtained indicated the potential use of the above series of compounds as promising antibacterial agents for the treatment of multidrug resistant Staphylococcus aureus infections."
06/16/2023 - "Using Targeted Nano-Antibiotics to Improve Antibiotic Efficacy against Staphylococcus aureus Infections."
10/01/2018 - "Photochemical internalization enhances cytosolic release of antibiotic and increases its efficacy against staphylococcal infection."
02/01/2004 - "This assay of bacterial replication was used to evaluate the efficacy of antibiotics which are commonly used to treat staphylococcal infections. "

06/01/2020 - "Furthermore, advantageous association with vancomycin resulted in significant protection against staphylococcal infection in Galleria mellonella model. "
03/01/2014 - "Vancomycin is the mainstay of treatment for patients with Staphylococcus aureus infections, and reduced susceptibility to vancomycin is becoming increasingly common. "
11/01/1981 - "Vancomycin is an effective and safe agent for treatment of staphylococcal infections in pediatric patients."
11/01/1981 - "Pharmacology and efficacy of vancomycin for staphylococcal infections in children."
11/01/1981 - "The current renewal of interest in vancomycin for treatment of severe staphylococcal infections stems primarily from the efficacy of this drug against methicillin-resistant pathogens and its utility in a number of unique clinical situations. "

03/01/1975 - "Initial studies indicate that rifampin may be useful for the treatment of Staphylococcus aureus infections. "
09/01/1972 - "Since rifampin is unique in its ability to kill intraleukocytic bacteria, the efficacy of this drug was tested in the treatment of staphylococcal infections in mice. "
12/10/2020 - "Addition of rifampin for staphylococcal infections may decrease relapse but requires further study."
07/01/2012 - "The role of rifampin against device-associated staphylococcal infection has been evaluated in an animal model, in observational studies and in a controlled trial. "
07/01/1983 - "Thus, there is firm in vitro and in vivo support for studies of the clinical efficacy of rifampin for staphylococcal infections."

01/01/2018 - "Vaccine display on artificial bacterial spores enhances protective efficacy against Staphylococcus aureus infection."
06/01/2003 - "FnBP-based vaccine strategies and novel anti-adherence tools based upon FnBP derivatives are in the early stages of investigation but may show promise in preventing staphylococcal infections."
01/01/2017 - "The results indicate the capsular vaccines elicit protection against some, but not all, aspects of staphylococcal infection."
05/01/1966 - "Enhancement of protection against staphylococcal infection by vaccines."
01/01/2017 - "Multiple candidate vaccines against Staphylococcus aureus infections have failed in clinical trials. "

06/01/2004 - "The introduction of penicillin in the 1940s greatly improved the prognosis for patients with severe staphylococcal infections. "
06/01/1962 - "[Renal and extrarenal clearance of penicillin from the blood plasma of rabbits in normal conditions and in experimental staphylococcal infection]."
08/01/2019 - "There is a high level of antimicrobial resistance to penicillin seen in our study, predominantly due to Staphylococcus aureus infection. "
07/01/1961 - "[1st trials of a new synthetic penicillin in the treatment of staphylococcal infections in children]."
12/01/2021 - "Correct determination of penicillin susceptibility is pivotal for using penicillin in the treatment of Staphylococcus aureus infections. "

12/01/2009 - "When a staphylococcal infection is suspected but the resistance phenotype is not known, agents that are effective against methicillin-susceptible S. "
12/01/2004 - "Community-acquired staphylococcal infections may be treated with agents effective against methicillin-sensitive strains."
12/01/2015 - "Effects of national antibiotic stewardship and infection control strategies on hospital-associated and community-associated meticillin-resistant Staphylococcus aureus infections across a region of Scotland: a non-linear time-series study."
07/16/2014 - "Resistance to the most common antimicrobials tested for in published studies and important for the treatment of staphylococcal infections in dogs were assessed separately for methicillin resistant (MRSP) and methicillin susceptible (MSSP) isolates. "
12/01/2011 - "The purpose of this study was to investigate whether the success seen in reducing meticillin-resistant Staphylococcus aureus infection rates could be duplicated with E. "

11/01/1993 - "Our results suggest that teicoplanin is highly effective and safe in neonatal staphylococcal infections."
11/01/2007 - "Previously published data suggest that a trough serum teicoplanin level of > or = 20 mg/l is predictive of improved outcomes in serious staphylococcal infection. "
04/01/1988 - "Poor efficacy of teicoplanin in treatment of deep-seated staphylococcal infections."
01/01/1996 - "In 2 studies where a dose of 6mg/kg/day was used, the mean concentrations did not exceed 10mg/L until day 7, while in the other study they were greater than 10mg/L beginning on day 1. A retrospective analysis of 58 clinical cases reported in the literature, 42 of whom had staphylococcal infections, indicated that serum concentrations and teicoplanin concentration/MIC ratios were related to clinical cure particularly for patients with staphylococcal infections. "
09/01/2004 - "We aimed to evaluate retrospectively the clinical and bacteriological efficacy and potential side-effects of teicoplanin treatment in neonates with proven staphylococcal infection. "

09/01/1958 - "The efficacy of erythromycin in the control and prevention of an endemic staphylococcal infection in a large private hospital nursery."
07/01/2005 - "These findings show that ethosomes are efficient carriers for erythromycin delivery to bacteria localized within the deep skin strata for eradication of staphylococcal infections."
02/01/1995 - "An outbreak of erythromycin-resistant, exfoliative toxin-producing Staphylococcus aureus infection in a neonatal unit is described. "
09/12/1979 - "For mild to moderate staphylococcal infections, erythromycin is indicated. "
12/01/1977 - "The staphylococcal infection rate in the units where erythromycin was used did not fall but the mortality rate from staphylococcal infection did."

04/23/1977 - "These studies showed that 18-hour diffusion sensitivity tests indicate the clinical value of treatment with flucloxacillin for staphylococcal infections of moderate severity more correctly at 37 degrees C than at 30 degrees C."
11/01/2009 - "Flucloxacillin, still the empirical choice for putative Staphylococcus aureus infections in intensive care units in the Netherlands."
08/01/1994 - "In addition, flucloxacillin (1-2 g every 4 h) could be added if there was clinical suspicion of staphylococcal infection. "
08/01/1993 - "In addition, flucloxacillin (1-2 g, every 4 h) could be added if there was clinical suspicion of staphylococcal infection (17 in each arm). "
01/01/1986 - "[Clinical evaluation of flucloxacillin in the treatment of serious staphylococcal infections in children]."

01/01/2000 - "aureus with mupirocin thus appears to be an effective measure to prevent postoperative staphylococcal infection in patients undergoing upper gastrointestinal surgery."
12/28/2019 - "Liposomal mupirocin holds promise for systemic treatment of invasive Staphylococcus aureus infections."
06/01/1994 - "The efficacy of intranasal mupirocin in the prevention of staphylococcal infections: a review of recent experience."
03/16/2004 - "Mupirocin prophylaxis against nosocomial Staphylococcus aureus infections in nonsurgical patients: a randomized study."
11/14/2023 - "Decolonization Strategies to Prevent Staphylococcal Infections: Mupirocin by a Nose."

08/01/2008 - "aureus, combined with improved methods of diagnosis, could be useful when dealing with persistent staphylococcal infections and could improve therapy."
01/01/2020 - "In this single-arm non-comparative trial, 13 patients in an Australian hospital with severe Staphylococcus aureus infections were intravenously administered a good manufacturing practice-quality preparation of three Myoviridae bacteriophages (AB-SA01) as adjunctive therapy. "
01/01/1987 - "A comparative experimental study was carried out of antigenic staphylococcal preparations developed in the USSR and Czechoslovakia for the immune therapy of chronic staphylococcal infection. "
10/01/1973 - "Studies on therapy of staphylococcal infections in monkeys. "
02/01/1970 - "Studies on therapy of staphylococcal infections in monkeys. "

01/01/2021 - "Overall, successful catheter salvage was achieved in 78% (96/123) of episodes, compared to 54% using systemic antimicrobials alone (P < .001), including mycobacterium, candida, and most staphylococcus aureus infections. "
01/01/2018 - "Staphylococcus aureus infections were also associated with an increased rate of catheter complications (aIRR: 2.13, 95% CI: 1.09-4.19), as were midline catheters (aIRR: 9.44, 95% CI: 2.12-41.97). "
01/01/2017 - "aureus carriage is as significant a risk factor as nasal carriage for staphylococcal infections in patients on HD through catheters. "
01/01/2014 - "PET/CT imaging with novel (68)Ga-DOTA-Siglec-9 tracer was able to detect inflammatory tissue response induced by catheter implantation and staphylococcal infections."
04/01/2005 - "At the tip of the catheter a staphylococcus aureus infection was detected. "

07/01/1987 - "Chemotherapy has changed the clinical spectrum of staphylococci but has not eradicated serious staphylococcal infections. "
07/31/2023 - "As such, Staphylococcus aureus infections are commonly seen in NSCLC patients receiving chemotherapy, and a major constituent of the S. "
01/01/2006 - "Due to high resistance, standard chemotherapy of biofilm-associated staphylococcal infections is ineffective and a number of alternative approaches to antimicrobial treatment have been proposed. "
04/01/2001 - "Evolving antimicrobial chemotherapy for Staphylococcus aureus infections: Our backs to the wall."
12/10/1990 - "[Drug therapy of intractable methicillin-resistant staphylococcal infections]."

01/01/2022 - "Bacteriophage Therapy for Staphylococcus Aureus Infections: A Review of Animal Models, Treatments, and Clinical Trials."
02/01/2023 - "Phage Therapy as an Alternative Treatment Modality for Resistant Staphylococcus aureus Infections."
01/01/2023 - "Alternative strategies, such as vaccination and phage therapy, are therefore actively being investigated to prevent or combat staphylococcal infections. "
01/01/2023 - "Amid existing efforts to resolve this problem, phage therapy proposes a hopeful alternate to face Staphylococcal infections. "
04/01/2022 - "Alternative techniques, such as anti-virulence and bacteriophage therapies, are being researched and may become major tools in the fight against staphylococcal infections in the future, in addition to the development of new small compounds that affect cell viability."

12/22/2018 - "Forty-one patients retained their instrumentation, whereas 1 patient had the implants removed because of Staphylococcus aureus infection, which was found the implants loosening during debridement. "
06/01/2009 - "Failure was more common after arthroscopic debridement, for previously revised joints and for Staphylococcus aureus infection. "
08/01/2008 - "To this aim, data from patients with implant staphylococcal infections (1998-2006) treated with debridement and implant retention were retrospectively reviewed. "
11/01/1997 - "Two unusual cases involving 2 patients with 3 hematogenously spread acute staphylococcal infections that occurred in musculotendinous compartments and required surgical debridement are reported. "
10/01/2003 - "Limited success with open debridement and retention of components in the treatment of acute Staphylococcus aureus infections after total knee arthroplasty."