SRS-A

A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed)

Also Known As:

Networked: 186 relevant articles (5 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kano, Hideyuki: 2 articles (01/2018 - 09/2014)
2.	Lunsford, L Dade: 2 articles (01/2018 - 09/2014)
3.	Niranjan, Ajay: 2 articles (01/2018 - 09/2014)
4.	Kamio, Yoko: 2 articles (12/2017 - 11/2014)
5.	Kunugi, Hiroshi: 2 articles (12/2017 - 11/2014)
6.	Matsuo, Junko: 2 articles (12/2017 - 11/2014)
7.	Eggermann, Thomas: 2 articles (06/2010 - 01/2008)
8.	Schönherr, N: 2 articles (01/2008 - 09/2006)
9.	Xie, Qiang-min: 2 articles (01/2007 - 01/2003)
10.	Al-Wassia, Rolina K: 1 article (09/2021)

Related Diseases

1.	Anaphylaxis (Anaphylactic Shock) 01/01/1986 - "These data indicate that O-2 generation occurring during acute airway anaphylaxis is associated with the activation of SRS-A products." 09/01/1983 - "Effect of inhibition of synthesis and receptor antagonism of SRS-A in cardiac anaphylaxis." 04/01/1982 - "The cardiac effects of pure synthetic LT are similar to those previously obtained with crude slow-reacting substance of anaphylaxis indicating that the prolonged contractile failure associated with systemic anaphylaxis largely could be due to the negative inotropic effect of LT. " 04/01/1979 - "In addition, several of the compounds inhibited the release of SRS-A from passively sensitized human chopped lung and protected guinea pigs from the effects of anaphylaxis in a modified Herxheimer test." 07/15/1977 - "Evidence from isolated bovine pulmonary vessels and respiratory smooth muscles suggests that bovine slow-reacting substance of anaphylaxis (SRS-Abov) may contribute to bronchoconstriction and pulmonary oedema during anaphylaxis in cattle. "
2.	Autistic Disorder (Autism) 12/01/2022 - "Study participants (aged 3-5 years) were drawn from the AJ Drexel Autism Institute clinic (n = 154) and Kaiser Permanente Northern California (n = 201) and block randomized to receive either the 16-item short SRS, a newly developed computer adaptive testing-SRS, or the published full-length SRS. " 01/01/2018 - "This study aims to determine the prevalence of autistic traits or ASD in adults with GD using two different data collection methods: (1) cross-sectional data using the social responsiveness scale-adults (SRS-A) and the autism quotient (AQ) (n = 63). " 05/01/2004 - "In this study we examined the factor structure of autistic traits using data from 226 child psychiatric patients with and without pervasive developmental disorders, employing cluster analysis of data from the Autism Diagnostic Interview-Revised (ADI-r) and principal components factor analysis of data from the Social Responsiveness Scale (SRS, a quantitative genetic measure of autistic traits formerly known as the Social Reciprocity Scale). " 07/01/2021 - "The AQ proved somewhat better than the SRS-A at discriminating and predicting autism. " 01/01/2019 - "Fifty-two young, intelligent adults with ASD (IQrange = 88-130, Agerange = 18-24) and 31 typically developing (TD) ASD (IQrange = 94-139, Agerange = 19-28) gender matched controls participated and reported on severity of autism symptoms [Social Responsiveness Scale for Adults (SRS-A)]. "
3.	Asthma (Bronchial Asthma) 03/08/2006 - "Twenty five years after the structure elucidation of slow reacting substance of anaphylaxis, antileukotrienes are established as a new therapeutic modality in asthma. " 06/01/2001 - "One of the important chemical mediators implicated in the pathogenesis of asthma is the slow-reacting substance of anaphylaxis, which was subsequently found to comprise LTs C4, D4, and E4. " 01/14/1991 - "bronchial asthma in which the smooth muscle contractile and permeability increasing properties of SRS-A appears to contribute to the early bronchoconstrictor phase. " 05/01/1989 - "The data suggest that higher AS-B activity during asthma attacks could inactivate SRS-A and modulate allergic inflammatory reaction." 03/01/1986 - "Bronchial asthma, leukocyte synthesis of slow-reacting substance of anaphylaxis, and other evidence for activation of blood cells in asthma."
4.	Neoplasm Metastasis (Metastasis) 01/01/2017 - "Stereotactic radiosurgery (SRS), a technique that is emerging as a new treatment option, has been reported to be an effective, noninvasive treatment for spine metastasis patients. " 03/01/1998 - "After SRS a decrease in metastasis diameter was observed in 10 of 14 NSC lung patients vs. 12 of 16 non-lung patients (p=0.85 Chi-square). " 09/01/2003 - "Thus, we conducted the current study concerning whether survival benefit existed in patients with controlled primary lesions and no other distant metastases, who were treated with stereotactic radiosurgery (SRS), a superior method for local control, for metastatic brain tumors. " 01/01/2023 - "Stereotactic radiosurgery (SRS), a therapy that uses radiation to treat brain tumors, has become a significant treatment procedure for patients with brain metastasis (BM). " 10/30/2020 - "Stereotactic Radiosurgery (SRS), a form of focused radiotherapy which is given to patients who have a limited number of brain metastases, delivers a higher radiation dose to the metastases resulting in better target lesion control. "
5.	Hemorrhage 09/01/2014 - "After SRS, a low rate of hemorrhage and improved seizure control were also evident." 05/01/2016 - "Comparing the risk of hemorrhage between the periods before and after SRS, a 53% risk reduction was achieved after SRS (hazard ratio, 0.47; 95% CI, 0.24-0.94; P=0.03), and 85% reduction was achieved after angiographic obliteration (hazard ratio, 0.15; 95% CI, 0.02-0.53; P=0.002). "

Related Drugs and Biologics

1.	FPL 55712
2.	Memantine (Namenda)
3.	traxanox
4.	Antigens
5.	Leukotrienes
6.	Immunoglobulin E (IgE)
7.	Ketotifen (Ketotifene)
8.	Histamine Antagonists (Antihistamines)
9.	Calcium
10.	SRS-A

Related Therapies and Procedures

1.	Therapeutics
2.	Vagotomy
3.	Operative Surgical Procedures
4.	Radiotherapy
5.	Microspheres (Microsphere)