Squalene

08/01/2000 - "In order to evaluate the overall implications of squalene to human cancer prevention, further studies are needed to fully identify its protective effects, as well as possible detrimental effects."
10/01/2018 - "Studies in vitro and in animal models suggest protective and inhibitory effects of squalene against cancer. "
11/11/2023 - "Squalene-derived polyethers are a unique class of compounds that display a great diversity of structures and a broad array of bioactivities, among which its notable antiproliferative activity stands out against various types of cancer cell lines. "
09/25/2022 - "To efficiently encapsulate PTM into biocompatible nanoparticles and to enhance its selectivity toward cancer cells, a squalene (SQ) derivative (1,1',2-tris-norsqualenoic acid, SQ-COOH) was selected to prepare PTM-loaded nanocarriers. "
01/01/2022 - "Collectively, these results identify a novel tumor-specific radiosensitizer by revealing unrecognized cross-talk between squalene metabolites, ER stress, and the DNA damage response. "

11/01/2020 - "GMTRs > 1.0 favoured squalene-IIV over aqueous IIV. For all influenza (sub-)types, the adjuvant effect proved negatively associated with pre-vaccination GMT and mean age. "
04/01/2015 - "Impact of squalene-based adjuvanted influenza vaccination on graft outcome in kidney transplant recipients."
01/01/1970 - "Increased serum levels of squalene in patients with acute influenza."
01/01/2022 - "The human LF chips demonstrate improved antibody responses to split virion influenza vaccination compared to 2D cultures, which are enhanced by a squalene-in-water emulsion adjuvant, and this is accompanied by increases in LF size and number. "
04/27/2011 - "Prospective parallel cohort field study enrolling children with confirmed influenza A/H1N1/09 disease or immunized with 1 (immunocompetent) or 2 (immunocompromised) doses of influenza A/H1N1/09 squalene-based AS03- or MF59-adjuvanted vaccines. "

01/01/2021 - "The results indicated that acne associates with site-specific derangement of the pathways regulating the balance among odd straight-chain and branched-chain SFAs, MUFAs, which included sapienate (C16:1n-10), PUFAs, and squalene."
08/01/2015 - "Squalene by-products, mostly under peroxidized forms, lead to comedogenesis, contribute to the development of inflammatory acne and possibly modify the skin relief (wrinkling). "
11/01/2006 - "Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris."
05/01/1986 - "We suggest that squalene oxidation is the link between comedogenesis and bacterial colonization, and based on this, we propose a hypothesis of the pathogenesis of acne."
05/01/1986 - "A possible role for squalene in the pathogenesis of acne. "

01/01/2022 - "Evaluating the efficacy of extracted squalene from seed oil in the form of microemulsion for the treatment of COVID-19: A clinical study."
01/01/2022 - "Our data suggest that squalene could be considered as a potential treatment for COVID-19, and further studies are required to confirm the results."
01/01/2022 - "This study investigates the effect of the nanostructure of squalene in the form of microemulsion on COVID-19 patients. "
09/25/2021 - "Assessment of adjuvantation strategy of lipid squalene nanoparticles for enhancing the immunogenicity of a SARS-CoV-2 spike subunit protein against COVID-19."
10/12/2022 - "Squalene, a medicinal terpene, is used as a vaccine adjuvant to improve the efficacy of vaccines, including pandemic coronavirus disease 2019 (COVID-19) vaccines, and plays diverse biological roles as an antioxidant and anticancer agent. "

11/01/2017 - "Correction: A Squalene-Based Nanomedicine for Oral Treatment of Colon Cancer."
01/01/2017 - "A Squalene-Based Nanomedicine for Oral Treatment of Colon Cancer."
02/01/1998 - "Chemopreventive effect of squalene on colon cancer."
02/15/2010 - "Mevalonate and geranylgeranyl pyrophosphate eliminated most of the growth inhibitory effect of ATST, but only marginally decreased that of gamma-TT; whereas farnesyl pyrophosphate and squalene exhibited little effect on the inhibitory action of ATST and gamma-TT, indicating protein geranylgeranylation, but not farnesylation are involved in the inhibition of colon cancer cell growth. "
10/01/2000 - "High consumption of extra-virgin olive oils, which are particularly rich in these phenolic antioxidants (as well as squalene and oleic acid), should afford considerable protection against cancer (colon, breast, skin), coronary heart disease, and ageing by inhibiting oxidative stress."