Sporotrichosis

The commonest and least serious of the deep mycoses, characterized by nodular lesions of the cutaneous and subcutaneous tissues. It is caused by inhalation of contaminated dust or by infection of a wound.

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Networked: 301 relevant articles (49 outcomes, 33 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Aspergillosis
3.	Histoplasmosis
4.	Blastomycosis
5.	Cryptococcosis

Experts

1.	Lopes-Bezerra, Leila M: 7 articles (02/2015 - 03/2008)
2.	de Camargo, Zoilo Pires: 4 articles (08/2015 - 01/2011)
3.	Carlos, Iracilda Zeppone: 4 articles (02/2015 - 01/2006)
4.	Galhardo, Maria Clara Gutierrez: 4 articles (08/2014 - 03/2011)
5.	Zancopé-Oliveira, Rosely Maria: 4 articles (08/2014 - 06/2004)
6.	Cleff, Marlete Brum: 4 articles (04/2014 - 10/2008)
7.	Pereira, Sandro A: 4 articles (04/2014 - 01/2007)
8.	Guarro, Josep: 3 articles (08/2015 - 05/2012)
9.	Schubach, Tânia Maria Pacheco: 3 articles (08/2015 - 01/2005)
10.	Fernandes, Geisa Ferreira: 3 articles (08/2015 - 01/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sporotrichosis:

1.	Itraconazole (Sporanox)FDA LinkGeneric 01/01/2008 - "Itraconazole is a triazole derivative leading to good results in the treatment of sporotrichosis. " 11/01/1989 - "Third, it suggests that itraconazole has significant promise in treating systemic sporotrichosis." 04/01/2015 - "The first therapeutic choice for the treatment of cutaneous sporotrichosis is oral itraconazole; however, the increase in cases of zoonotic transmission outbreak necessitates a search for effective and safe treatment alternatives. " 01/01/2008 - "Intermittent or pulsed itraconazole was effective in treating cutaneous sporotrichosis. " 05/01/1992 - "These results show that itraconazole represents a safe and effective drug for the treatment of sporotrichosis. "
2.	Potassium Iodide (Pima)FDA Link 04/01/1996 - "Patients with culture-confirmed cutaneous sporotrichosis were entered in a randomized, nonblinded study to compare the safety and efficacy of qd vs. tid dosage of SSKI. " 03/01/2005 - "In all, 304 cases of sporotrichosis confirmed by fungal culture, histopathologic examination, and/or remission of lesions with potassium iodide were reviewed. " 04/01/2015 - "New posology of potassium iodide for the treatment of cutaneous sporotrichosis: study of efficacy and safety in 102 patients." 06/01/2009 - "We carried out a review of published studies on the benefits and adverse reactions of using SSKI (Saturated Solution Potassium Iodide) as treatment for sporotrichosis, but could not identify any well-designed clinical trails. " 04/01/1996 - "These findings suggest that a single daily full dose of SSKI appears to be appropriate therapy for cutaneous sporotrichosis; further studies with larger numbers of patients are required."
3.	terbinafine (Lamisil)FDA LinkGeneric 01/01/2014 - "Terbinafine has been observed to be effective in the treatment of cutaneous sporotrichosis. " 02/01/2004 - "Both doses of terbinafine were well-tolerated and effective for the treatment of sporotrichosis. " 11/01/2009 - "Terbinafine (250 mg/day): an effective and safe treatment of cutaneous sporotrichosis." 02/01/2004 - "The aim of this study was to evaluate the safety and efficacy of oral terbinafine (500 and 1000 mg day(-1)) in the treatment of cutaneous or lymphocutaneous sporotrichosis. " 01/01/2014 - "A 65-year-old African woman was diagnosed with a fixed cutaneous sporotrichosis on her left arm, treated with itraconazol and oral terbinafine with partial improvement. "
4.	Amphotericin B (Amphotericin)FDA LinkGeneric 06/01/2012 - "Two cases with disseminated cutaneous sporotrichosis were treated with intravenous amphotericin B. " 08/01/2009 - "Intralesional amphotericin B in a cat with refractory localised sporotrichosis." 04/01/2000 - "Meningeal and disseminated forms of sporotrichosis are rare and usually require treatment with amphotericin B. " 02/01/1999 - "While localized sporotrichosis is an innocuous disorder that responds well to therapy, in immunocompromised hosts, it is potentially life-threatening and may require prolonged therapy with potentially toxic medications such as amphotericin B. " 04/01/1989 - "Intravenous amphotericin B is still considered the drug of choice for systemic sporotrichosis, but the search for a less toxic agent continues. "
5.	Ketoconazole (Nizoral)FDA LinkGeneric 02/01/1987 - "The diagnosis of sporotrichosis was made using a direct smear preparation and confirmed by the findings of histological studies and those obtained via culture ketoconazole therapy led to a significant reduction of the lesions." 07/01/1987 - "On the basis of this case and the modest amount of experience reported in the literature, ketoconazole does not appear to be effective in the treatment of pulmonary sporotrichosis." 01/01/1993 - "Immunologically normal children and adults with lymphocutaneous or cutaneous sporotrichosis may respond well to ketoconazole therapy." 01/01/1993 - "Ketoconazole treatment of a family with zoonotic sporotrichosis." 09/01/1992 - "Successful treatment of disseminated cutaneous sporotrichosis with ketoconazole."
6.	Fluconazole (Zonal)FDA LinkGeneric 07/01/1994 - "A case of sporotrichosis treated successfully with oral fluconazole 200 mg once weekly." 07/01/1994 - "Reports on the efficacy of once-weekly fluconazole administration in cases of sporotrichosis have appeared, but it would be valuable to study more such cases." 01/01/1996 - "Fluconazole therapy cured 10 (71%) of 14 patients with lymphocutaneous sporotrichosis. " 04/01/2006 - "We report a case of invasive pulmonary sporotrichosis in an eleven year old HIV-infected boy in Kinshasa, Democratic Republic of the Congo, successfully treated with oral fluconazole." 01/01/2000 - "An unusual case of cutaneous sporotrichosis and its response to weekly fluconazole."
7.	IodineIBA 05/07/1986 - "Oral iodine is also very effective in the lymphatic-cutaneous form of sporotrichosis. " 02/01/1956 - "Radioautographic study of experimental sporotrichosis after the administration of radioactive iodine." 07/01/1996 - "Chronic sporotrichosis granuloma of the skin is usually the result of non compliance with oral iodine therapy for whatever reason. " 07/01/1996 - "Response of sporotrichosis granuloma to local application of iodine." 04/01/1955 - "The distribution of radioactive iodine (I-131) in experimental coccidioidomycosis and sporotrichosis."
8.	posaconazoleFDA Link 08/01/2015 - "In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficacy in terms of survival and burden reduction was increased with the combination. " 05/01/2012 - "We developed a murine model of systemic sporotrichosis by using three strains of each of the two commonest species causing sporotrichosis, i.e., Sporothrix schenckii sensu stricto and Sporothrix brasiliensis, in order to evaluate the efficacy of posaconazole (PSC). " 05/01/2012 - "Efficacy of posaconazole in murine experimental sporotrichosis." 12/01/2007 - "Posaconazole is effective against yeasts and molds and could be effective in treating rare fungal infections involving Zygomycetes, Mucor necrotizing fasciitis, rhinocerebral mucormycosis, some Fusarium species, Penicillium, Histoplasma, Blastomyces, Coccidioides, Paracoccidioides, and sporotrichosis, chromoblastomycosis, mycetoma, and phaeohyphomycosis, including Scedosporium apiospermum and Exophiala, Alternaria, and Bipolaris species. " 08/01/2015 - "In Vitro and In Vivo Efficacy of Amphotericin B Combined with Posaconazole against Experimental Disseminated Sporotrichosis."
9.	AzolesIBA 09/01/2010 - "Potassium iodide is an effective treatment for sporotrichosis, but this agent has not been subjected to specific treatment trials comparing its efficacy against azoles or allylamine alternatives. " 04/01/1989 - "From the first report of the efficacy of the iodides for the treatment of sporotrichosis (1903) until the introduction of the imidazoles (azoles, 1960s), the number of antifungal agents available was very limited, including griseofulvin (1939), nystatin (1950), amphotericin B (1956), and flucytosine (1964). "
10.	Griseofulvin (Grifulvin V)FDA LinkGeneric 06/01/1965 - "A CASE OF SPOROTRICHOSIS CLEARED WHEN GIVEN GRISEOFULVIN." 11/19/1960 - "Sporotrichosis treated by griseofulvin--a failure." 10/20/1960 - "[Sporotrichosis treated with griseofulvin]." 06/01/1959 - "[2 Cases of sporotrichosis treated with griseofulvin]." 06/01/1964 - "SPOROTRICHOSIS TREATED WITH GRISEOFULVIN AND IODIDES."

Therapies and Procedures

1.	Lasers (Laser) 10/01/2014 - "The in vitro inhibition of Sporothrix spp. isolates by laser light deserves in vivo experimental and clinical studies since it may be a promising treatment for cutaneous and subcutaneous sporotrichosis. "
2.	Intraperitoneal Injections 02/01/1998 - "After intravenous or intraperitoneal injection of 106 cfu of yeast forms, three of four isolates from cutaneous sporotrichosis were unable to establish infection and were eliminated from blood and visceral organs. "
3.	Drug Therapy (Chemotherapy) 03/01/1985 - "Chronic cavitary pulmonary sporotrichosis is usually refractory to drug therapy; however, when combined with surgical resection, cure can be attained." 07/01/1976 - "The other, with extensive pulmonary sporotrichosis, continued to have sputum cultures positive for S schenckii during three years of intensive chemotherapy." 01/01/1973 - "No effective chemotherapy is available for cladosporiosis, and systemic sporotrichosis can be very resistant to antifungal chemotherapy. " 08/01/2005 - "We describe a case of sporotrichosis in a 50-year-old woman, who underwent mastectomy due to breast carcinoma, followed by radiation and chemotherapy. " 07/01/1980 - "Successful chemotherapy of the systemic mycoses now covers a span of more than 75 years and dates to the first reported use of potassium iodide for treatment of sporotrichosis. "
4.	Photochemotherapy (Photodynamic Therapy) 01/01/2014 - "Cutaneous sporotrichosis treated with photodynamic therapy: an in vitro and in vivo study."
5.	Induced Hyperthermia (Thermotherapy) 02/13/2010 - "Use of local hyperthermia to treat sporotrichosis in a cat." 07/01/1987 - "Local hyperthermia in the treatment of sporotrichosis." 12/01/1983 - "In order to clarify the mechanism of action of topical thermotherapy on sporotrichosis, the effects of heat on Sporothrix schenckii in vitro and in vivo were investigated by observing the percentage germination and the ultrastructure. " 10/01/1981 - "[Local thermotherapy in sporotrichosis]." 02/01/1968 - "[Sporotrichosis in the western part of Japan--report of cases and topical thermotherapy]."