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Ankylosing Spondylitis

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A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.
Also Known As:
Spondylitis, Ankylosing; Ankylosing Spondylarthritis; Ankylosing Spondyloarthritis; Bechterew's Disease; Ankylosing Spondylarthritides; Ankylosing Spondyloarthritides; Bechterews Disease; Marie Struempell Disease; Spondylarthritides, Ankylosing; Spondylarthritis, Ankylosing; Spondylitis, Rheumatoid; Spondyloarthritides, Ankylosing; Spondyloarthritis, Ankylosing; Bechterew Disease; Marie-Struempell Disease; Rheumatoid Spondylitis; Spondylarthritis Ankylopoietica
Networked: 3987 relevant articles (292 outcomes, 633 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Rheumatoid Arthritis
2. Psoriatic Arthritis
3. Arthritis (Polyarthritis)
4. Osteoarthritis
5. Psoriasis (Pustulosis Palmaris et Plantaris)

Experts

1. Sieper, J: 72 articles (10/2015 - 02/2000)
2. Braun, J: 69 articles (01/2016 - 02/2000)
3. Sieper, Joachim: 67 articles (12/2015 - 01/2002)
4. Braun, Jürgen: 52 articles (12/2015 - 02/2003)
5. van der Heijde, Désirée: 50 articles (12/2015 - 03/2003)
6. Inman, Robert D: 48 articles (06/2015 - 03/2003)
7. Maksymowych, Walter P: 38 articles (01/2015 - 03/2002)
8. Rudwaleit, M: 36 articles (03/2015 - 01/2001)
9. Rudwaleit, Martin: 34 articles (09/2015 - 03/2003)
10. Dougados, Maxime: 33 articles (12/2015 - 09/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ankylosing Spondylitis:
1. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
2. TNFR-Fc fusion protein (etanercept)FDA Link
3. infliximab (Remicade)FDA Link
4. adalimumab (Humira)FDA Link
5. Sulfasalazine (Azulfidine)FDA LinkGeneric
6. Methotrexate (Mexate)FDA LinkGeneric
7. Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
8. Indomethacin (Indometacin)FDA LinkGeneric
9. golimumabFDA Link
10. C-Reactive ProteinIBA
01/01/2014 - "Patients with <4 years and ≥4 years of disease were compared for improvement in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Ankylosing Spondylitis Disease Activity Score (ASDAS), C-reactive protein (CRP) and magnetic resonance imaging (MRI) score for sacroiliac joints (SIJ). "
11/01/2010 - "Parameters at baseline/1-year follow-up were: C-reactive protein (CRP): 14 (7-27)/5 (2-10) mg/l, BASDAI 59 (44-72)/21 (8-39) mm, Bath Ankylosing Spondylitis Functional Index (BASFI) 50 (34-67)/24 (9-45) mm, Bath Ankylosing Spondylitis Metrology Index 40 (20-50)/20 (10-40) mm. Within 6 months, 407/644 patients (63%) achieved a clinical response. "
06/01/2015 - "The aim of this study was to assess discriminant validity of Ankylosing Spondylitis Disease Activity Score (ASDAS)-C-reactive protein (-CRP) and ASDAS-erythrocyte sedimentation rate (-ESR) and to compare with The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) as clinical tools for the measurement of disease activity in patients with non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS). "
07/01/2012 - "At the same time, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI) and Bath Ankylosing Spondylitis Patient Global Score (BAS-G) levels were measured, and physical examinations were performed on study participants to determine their extent of physical mobility. "
06/01/2012 - "The objective of this study is to evaluate the role of MMP-3 and MRI in assessing disease activity in sacroiliac joints of AS patients in comparison to the conventional measures Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). "

Therapies and Procedures

1. Biological Therapy
2. Osteotomy
3. Balneology
4. Aftercare (After-Treatment)
01/01/2013 - "Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI), Bath ankylosing spondylitis metrology index (BASMI), ESR and CRP expression levels were compared before treatment, 12 h after treatment and 24 h after treatment. "
04/19/2011 - "The radiological assessments of mSASSS (modified Stoke ankylosing spondylitis spine score) were recorded at baseline, 3, 6 & 12 months after treatment. "
11/01/2009 - "Before and after treatment, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) was measured, and all patients completed the International Index of Erectile Function (IIEF) questionnaire, a self-administered measure of sexual dysfunction with five domains: erectile function (EF), intercourse satisfaction (IS), orgasmic function (OF), sexual desire (SD) and overall satisfaction (OS). "
04/01/2007 - "Readers scored each set of MRI 3 times, using 3 different methods including the Ankylosing Spondylitis spine Magnetic Resonance Imaging-activity [ASspiMRI-a, grading activity (0-6) per vertebral unit in 23 units]; the Berlin modification of the ASspiMRI-a; and the Spondyloarthritis Research Consortium of Canada (SPARCC) scoring system, which scores the 6 vertebral units considered by the reader as the most abnormal, with additional scores for "depth" and "intensity." Both the order of the methods used by each reader and the timepoints (before/after treatment) were randomized. "
10/01/2010 - "The patients were evaluated using the global index, Bath ankylosing spondylitis disease activity index (BASDAI), disease functional index (BASFI), metrology index (BASMI), chest expansion measures, pulmonary function testing, and the medical outcomes study-short form-36 Health Survey (SF-36) (measure of quality of life) before balneotherapy and 1 month after treatment. "
5. Drug Therapy (Chemotherapy)