Splenic Infarction

Insufficiency of arterial or venous blood supply to the spleen due to emboli, thrombi, vascular torsion, or pressure that produces a macroscopic area of necrosis. (From Stedman, 25th ed)

Also Known As:

Networked: 210 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Sickle Cell Trait
2.	Neoplasms (Cancer)
3.	Hematuria
4.	Anoxia (Hypoxia)
5.	Abscess

Experts

1.	Al-Salem, Ahmed H: 4 articles (03/2013 - 04/2003)
2.	Kadikoylu, Gurhan: 2 articles (07/2012 - 04/2006)
3.	Yavasoglu, Irfan: 2 articles (07/2012 - 04/2006)
4.	Bolaman, Zahit: 2 articles (07/2012 - 04/2006)
5.	Kurt, Mevlut: 2 articles (10/2010 - 01/2010)
6.	Hasani, A: 1 article (12/2015)
7.	Musto, K R: 1 article (12/2015)
8.	Musk, A W: 1 article (12/2015)
9.	Tiemeier, A M: 1 article (12/2015)
10.	Creaney, J: 1 article (12/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Splenic Infarction:

1.	sorafenib (BAY 43-9006)FDA Link 01/14/2011 - "The splenic infarction improved after sorafenib was discontinued; however, the HCC progressed." 01/14/2011 - "The patient had no other predisposing factors to explain the splenic infarction except for the administration of sorafenib. " 01/14/2011 - "Here, a case of splenic infarction in a patient with HCC who was treated with sorafenib is reported. " 01/14/2011 - "However, there are no prior reports of splenic infarction as an adverse effect of sorafenib. " 01/14/2011 - "Splenic infarction associated with sorafenib use in a hepatocellular carcinoma patient."
2.	First StepIBA 05/01/2009 - "Studies to compare the prevalence of events (splenic infarction and hematuria) in sickle cell trait with and without OSA, as well as their relationship to exposure to environmental hypoxia will be a first step in verifying this hypothesis."
3.	Antiphospholipid AntibodiesIBA 01/01/2004 - "There are few cases of splenic infarction associated with antiphospholipid antibody reported in the literature. " 12/01/2009 - "Splenic infarction: a rare cause of acute abdominal pain presenting in an older patient with primary antiphospholipid antibodies syndrome." 01/01/2007 - "We report 2 children with Mycoplasma pneumoniae pulmonary infection with splenic infarcts and transient antiphospholipid antibodies. " 03/01/2005 - "We report the first case of splenic infarction during acute EBV infection associated with the transient induction of antiphospholipid antibodies. " 03/01/2005 - "Splenic infarction due to transient antiphospholipid antibodies induced by acute Epstein-Barr virus infection."
4.	EnbucrilateIBA 10/01/2010 - "One patient developed splenic infarction a day after N-butyl-2-cyanoacrylate injection. " 10/01/2013 - "Herein, we present a patient who developed splenic infarction after N-butyl-cyanoacrylate injection for gastroesophageal varices type 2 and discuss the potential reasons and tips to prevent the occurence of embolization. " 10/01/2013 - "Splenic infarction after N-butyl-2-cyanoacrylate injection for gastric varices: why does it happen?" 09/14/2013 - "Herein, we report a case of cerebral and splenic infarctions after the injection of N-butyl-2-cyanoacrylate to treat esophageal variceal bleeding. " 09/14/2013 - "Cerebral and splenic infarctions after injection of N-butyl-2-cyanoacrylate in esophageal variceal bleeding."
5.	Anticardiolipin AntibodiesIBA 01/01/2009 - "He was positive for anticardiolipin antibody, showed splenic infarction on abdominal CT scan. " 01/01/2004 - "We present two cases of splenic infarction associated with anticardiolipin antibody, one complicated by the development of a splenic pseudocyst. " 11/01/2005 - "Here we describe a 20-year-old pregnant woman with systemic lupus erythematosus who had high anticardiolipin antibodies and presented with splenic infarction." 02/01/1999 - "[Splenic infarction in a patient with anticardiolipin antibodies and leptospirosis]." 06/01/1993 - "This case report suggests that anticardiolipin antibodies are associated with splenic infarction and that anticardiolipin antibodies associated with AIDS may sometimes be clinically significant."
6.	Sickle HemoglobinIBA 07/01/2013 - "Massive splenic infarction in an adolescent with hemoglobin S-HPFH." 08/01/1988 - "We describe a 15-year-old black boy with hemoglobin S-C disease living in Atlanta (altitude 1,034 ft), with no prior history of aircraft or mountain travel, who developed splenic infarction. " 08/01/1988 - "Splenic infarction at low altitude in a child with hemoglobin S-C disease." 03/01/1985 - "We describe four instances of acute splenic infarction in three patients with hemoglobin S-C disease which illustrate a wide spectrum of clinical manifestations and severity. " 03/01/1985 - "Splenic infarction, splenic sequestration, and functional hyposplenism in hemoglobin S-C disease."
7.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 09/01/2011 - "Multiple patient parameters were examined and chi-squared analysis was used to evaluate the association between the operative technique (SVP or splenic vessel division [SVD]) and splenic infarction. " 02/01/2000 - "We describe a patient who sustained splenic infarction secondary to diabetes-induced, small-vessel atherosclerotic disease." 09/01/2011 - "Laparoscopic spleen-preserving distal pancreatectomy in elderly subjects: splenic vessel sacrifice may be associated with a higher rate of splenic infarction." 06/01/2015 - "Among 6 cases receiving aorta-splenic artery bypass, 1 gradually developed stenosis at anatomosed site, which eventually progressed to complete occlusion 2 years to 6 years after operation, without suffering from splenic infarction because the spleen was supplied by the short gastric vessel and its collaterals. " 06/01/2008 - "A case of murine typhus associated with large vessel infarct of the spleen."
8.	Lupus Coagulation Inhibitor (Lupus Anticoagulant)IBA 03/01/1989 - "The authors report a thrombotic manifestation, spontaneous isolated splenic infarction that occurred in a young man with circulating lupus anticoagulant." 01/01/2010 - "We present the case of a 47-year-old previously healthy man in which a presumptive diagnosis of antiphospholipid syndrome was made based on the absence of echocardiographically detected heart involvement, a negative blood culture, normal C-reactive protein (CRP) levels, a positive lupus anticoagulant (LAC) test, and evidence of splenic infarcts. " 09/01/1988 - "A 37-year-old female, known to have systemic lupus erythematosus (SLE) and markedly raised anti-cardiolipin antibody levels in association with the lupus anticoagulant, presented with a symptomatic segmental splenic infarction. " 01/01/2000 - "His laboratory data on admission showed that lupus anticoagulant was positive, together with a high value of beta-thromboglobulin, thrombin-antithrombin III complex, markers of platelet and coagulation activation, CEA and CA 19-9. The autopsy finding revealed a primary papillary adenocarcinoma in the right lower lung, multiple cerebral infarction, renal infarction, pulmonary infarction and splenic infarction. "
9.	Cardiolipins (Cardiolipin)IBA 01/01/2004 - "Splenic infarction associated with anti-cardiolipin antibody: a report of two cases." 10/01/1999 - "Q-fever associated with splenic infarction and an anti-cardiolipin antibody." 08/01/1999 - "Antiphospholipid syndrome (APS) was confirmed by positive response to anti-cardiolipin antibody and recurrent splenic infarction. " 09/01/1988 - "A 37-year-old female, known to have systemic lupus erythematosus (SLE) and markedly raised anti-cardiolipin antibody levels in association with the lupus anticoagulant, presented with a symptomatic segmental splenic infarction. "
10.	tranilast (N 5')IBA 06/01/2006 - "Final clinical diagnoses of splenic abnormalities were no specific diagnosis (n = 13), complete autosplenectomy (n = 2), splenic lymphoma (n = 5), and splenic infarction (n = 11). " 03/01/2004 - "Complications related to procedure included transient hematuria (n=5), puncture site oozing (n=1) and partial splenic infarction (n=1), and all were conservatively managed. " 06/01/2004 - "Sixty-two abnormalities, detected in 41 patients, included leak (n = 12), loculated fluid collection unrelated to leak (n = 9), markedly distended excluded stomach (n = 6), small-bowel obstruction (n = 6), gastric staple line dehiscence (n = 6), splenic infarction (n = 5), hematoma (n = 5), left hepatic lobe infarction (n = 3), and hernia related to gastric bypass (n = 10, including three internal hernias, three incisional hernias, and four nonincisional ventral hernias). " 05/01/1998 - "These complications included acute hepatic failure (n = 6), liver infarction (n = 4) or abscess (n = 5), intrahepatic biloma (n = 20), multiple intrahepatic aneurysms (n = 6), cholecystitis (n = 7), splenic infarction (n = 2), gastrointestinal mucosal lesions (n = 5), pulmonary embolism or infarction (n = 4), tumor rupture (n = 1), variceal bleeding (n = 3), and iatrogenic dissection (n = 35) or perforation (n = 4) of the celiac artery and its branches. "

Therapies and Procedures

1.	Surgical Splenorenal Shunt (Splenorenal Shunt) 01/01/2014 - "Spontaneous resolution of splenic infarcts after distal splenorenal shunt in children with extra hepatic portal venous obstruction: our experience." 01/01/2014 - "Spleen-preserving distal splenorenal shunt can be considered as a viable option in the management of cases with mild and carefully selected moderate splenic infarcts." 05/01/2002 - "Indications were thrombocytopenia in 6 cases, portal flow disturbances due to splenorenal shunt in four, and splenic infarction in one. " 01/01/2014 - "In cases of portal hypertension with splenic infarcts, splenectomy with proximal splenorenal shunt has been recommended. " 11/01/1978 - "Symptoms of splenic infarction were observed in six patients, resulting in thrombosis of the splenic vein and/or of the distal splenorenal shunt in four patients and necessitating splenectomy in one. "
2.	Aftercare (After-Treatment) 12/01/2014 - "Improved findings after treatment were observed in 8 (88.9%) of 9 patients with splenic infarction on follow-up by computed tomography or ultrasonography. "
3.	Splenectomy 10/01/1986 - "The study was also useful in detecting splenic infarction and in following enlargement of the spleen after partial splenectomy. " 01/01/2015 - "Splenectomy was performed due to splenic infarction. " 10/01/2014 - "Massive splenic infarction and PVT treated with splenectomy in one and with medical treatment in another in whom PVT resolved by cytoreductive treatment, led to downsizing of spleen or splenectomy. " 01/01/2014 - "This required a splenectomy due to splenic infarction. " 06/01/2013 - "Considering complications, splenic infarction and splenectomy occurred more frequently in WT patients (P < 0.05). "
4.	Gastrectomy 08/01/2012 - "Splenic infarction following conventional open gastrectomy in patients with gastric malignancy: a CT-based study." 01/01/2000 - "We present a 59-year-old patient in whom the splenic artery was accidentally ligated during gastrectomy surgery, with resultant splenic infarction. " 08/01/2012 - "The aim of this CT-based study was to investigate the frequency of splenic infarction (SI) following conventional open gastrectomy performed for gastric malignant neoplasms. " 01/01/2013 - "Gastric remnant necrosis following splenic infarction after distal gastrectomy in a gastric cancer patient."
5.	Laparotomy 01/01/2008 - "The decision was taken to proceed to laparotomy, which revealed both gastric and splenic infarction. " 04/01/1990 - "Computerized tomography suggested splenic infarction, which was documented by radionuclide liver-spleen scan and magnetic resonance imaging (MRI); the patient's spleen had been normal at exploratory laparotomy three weeks previously. " 09/01/1984 - "Laparotomy revealed torsion of the splenic pedicle and extensive splenic infarction. " 12/01/2007 - "He underwent an urgent laparotomy, which revealed a splenic infarction and thrombosis of the celiac artery all the way to the porta hepatis. " 12/01/2011 - "Patient was managed by urgent laparotomy and splenectomy, because of splenic vessels thrombosis and splenic infarction. "