Spirochaetales Infections

Infections with bacteria of the order SPIROCHAETALES.

Also Known As:

Infections, Spirochaetales; Infections, Spirochete; Infection, Spirochaetales; Infection, Spirochete; Spirochaetales Infection; Spirochete Infection; Spirochete Infections

Networked: 27 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Infections: 526564
- Bacterial Infections and Mycoses: 1
  - Bacterial Infections: 24368
    - Gram-Negative Bacterial Infections: 918
      - Spirochaetales Infections: 27
        Leptospirosis: 2086
        Borrelia Infections: 90
        Treponemal Infections: 52

Related Diseases

1.	Lyme Disease (Disease, Lyme)
2.	Tick Bites
3.	Tick-Borne Diseases (Tick-Borne Disease)
4.	Syphilis
5.	Skin Manifestations

Experts

1.	Pal, Utpal: 3 articles (01/2018 - 01/2012)
2.	Piesman, Joseph: 3 articles (01/2014 - 05/2003)
3.	Hojgaard, Andrias: 2 articles (01/2018 - 01/2014)
4.	Kraiczy, Peter: 2 articles (01/2018 - 10/2010)
5.	Yang, Xiuli: 2 articles (01/2018 - 01/2017)
6.	Smith, Alexis A: 2 articles (01/2017 - 01/2012)
7.	Dolan, Marc C: 2 articles (01/2014 - 05/2008)
8.	Ullmann, Amy J: 2 articles (01/2014 - 05/2003)
9.	Eisen, Rebecca J: 1 article (01/2018)
10.	Fleshman, Amy C: 1 article (01/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Spirochaetales Infections:

1.	Anti-Bacterial Agents (Antibiotics)IBA 05/01/2008 - "Spirochete infection was cleared in 88.9% to 100% of infected nymphs feeding on mice fed 250 and 500 mg/Kg antibiotic bait formulations, respectively. " 01/01/2014 - "As an alternative to oral prophylaxis for the prevention of tick transmission of Borrelia burgdorferi, we tested antibiotic cream prophylactic formulations in a murine model of spirochete infection. " 06/01/2015 - "The Jarisch-Herxheimer reaction (JHR) is a transient inflammatory syndrome triggered hours after the start of antibiotic treatment of spirochete infections, namely syphilis. "
2.	AntibodiesIBA 01/01/2018 - "Immunizing mice with modified VLP-CspZ cleared spirochete infection, as did passive transfer of elicited antibodies. " 01/01/2013 - "Extension of PCR method in laboratory diagnostics of Lyme disease (LD) gives a possibility of confirmation of spirochete infection before patient body managed to produce antibodies. "
3.	DNA VaccinesIBA 02/01/2012 - "These results indicate that the Gpd-IL-2 fusion DNA vaccine vectored by CS nanoparticles can efficiently induce Th1-dominant immune responses, improve protective efficacy against Tp spirochete infection, and effectively attenuate development of syphilitic lesions."
4.	FlagellinIBA 02/01/1992 - "These studies suggest that OspA and OspB, but not flagellin, play roles in protective immunity to spirochete infection."
5.	Interleukin-17 (Interleukin 17)IBA 10/14/2010 - "Since neutrophilic inflammation, indicative of IL-17 bioactivity, is scarcely observed in Erythema migrans, a manifestation of skin inflammation after infection, protective and antibacterial properties of IL-22 may close this gap and serve essential functions in the initial phase of spirochete infection."
6.	TylosinIBA 08/01/1976 - "[Tylosin in the treatment of spirochete infections in chickens]."
7.	ValeratesIBA 04/01/2007 - "Lower concentrations of iso-butyrate and iso-valerate were likely associated with development of pathogenic spirochete infection."
8.	VaccinesIBA 01/01/2018 - "In addition, lipoprotein vaccines have been developed for generating an immune response to control or prevent a spirochete infection. "
9.	16S Ribosomal RNAIBA 03/01/2005 - "This technique, based on single nucleotide polymorphisms of the 16S ribosomal RNA gene, was used to test blood samples from 7,750 patients, 33 of whom were diagnosed with spirochete infections. "
10.	Phosphopyruvate Hydratase (Enolase)IBA 01/01/2012 - "As expected, enolase displayed consistent expression in vivo, however, with a variable temporal and spatial expression during spirochete infection in mice and ticks. " 01/01/2012 - "Strategies to interfere with the function of surface enolase could contribute to the development of novel preventive measures to interrupt the spirochete infection cycle and reduce the incidences of Lyme disease."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 10/31/1919 - "CHEMOTHERAPY OF TRYPANOSOME AND SPIROCHETE INFECTIONS : BIOLOGICAL SERIES. " 10/31/1919 - "CHEMOTHERAPY OF TRYPANOSOME AND SPIROCHETE INFECTIONS : BIOLOGICAL SERIES. " 10/31/1919 - "CHEMOTHERAPY OF TRYPANOSOME AND SPIROCHETE INFECTIONS : BIOLOGICAL SERIES. " 10/31/1919 - "CHEMOTHERAPY OF TRYPANOSOME AND SPIROCHETE INFECTIONS : BIOLOGICAL SERIES. " 10/31/1919 - "CHEMOTHERAPY OF TRYPANOSOME AND SPIROCHETE INFECTIONS : CHEMICAL SERIES. "
2.	Transcutaneous Electric Nerve Stimulation (TENS) 01/01/2018 - "Anaplasmosis, babesiosis, and Borrelia spirochete infections, including Lyme borreliosis, account for tens of thousands of reported cases of tick-borne disease every year. "