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Spinal Injuries (Spinal Injury)

Injuries involving the vertebral column.
Also Known As:
Spinal Injury; Injuries, Spinal; Injury, Spinal
Networked: 1071 relevant articles (53 outcomes, 98 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Pain (Aches)
2. Wounds and Injuries (Trauma)
3. Spinal Cord Injuries (Spinal Cord Injury)
4. Infections
5. Ischemia

Experts

1. Aarabi, Bizhan: 8 articles (01/2021 - 09/2012)
2. Fehlings, Michael G: 7 articles (01/2021 - 05/2011)
3. Nistri, A: 6 articles (09/2011 - 01/2004)
4. Du, Xing: 5 articles (01/2021 - 01/2017)
5. Luo, Wei: 5 articles (01/2021 - 01/2017)
6. Mitchell, Gordon S: 5 articles (01/2021 - 01/2004)
7. Ou, Yunsheng: 5 articles (01/2021 - 01/2017)
8. Simard, J Marc: 5 articles (01/2021 - 01/2017)
9. Zhu, Yong: 5 articles (01/2021 - 01/2017)
10. Quan, Zhengxue: 5 articles (12/2020 - 07/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Spinal Injuries:
1. Naloxone (Narcan)FDA LinkGeneric
2. Opiate AlkaloidsIBA
3. Thyrotropin-Releasing Hormone (Protirelin)FDA Link
4. Proteins (Proteins, Gene)FDA Link
5. Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA
6. Enoxaparin (Lovenox)FDA LinkGeneric
7. Amino AcidsFDA Link
8. Cimetidine (Biomet)FDA LinkGeneric
9. FleroxacinIBA
10. Etoposide (VP 16)FDA LinkGeneric

Therapies and Procedures

1. Decompression
01/01/2019 - "After the follow-up period, the early decompression group showed improved American Spinal Injury Association Impairment Scale (AIS) grades (p < 0.040) and a higher AIS conversion (p < 0.021). "
11/01/2020 - "Response to Burke et al.: Efficacy of Ultra-Early (<12 h), Early (12-24 h), and Late (>24-138.5 h) Surgery with Magnetic Resonance Imaging-Confirmed Decompression in American Spinal Injury Association Impairment Scale Grades A, B, and C Cervical Spinal Cord Injury (DOI: 10.1089/neu.2020.7034)."
01/01/2020 - "Efficacy of Ultra-Early (< 12 h), Early (12-24 h), and Late (>24-138.5 h) Surgery with Magnetic Resonance Imaging-Confirmed Decompression in American Spinal Injury Association Impairment Scale Grades A, B, and C Cervical Spinal Cord Injury."
01/01/2020 - "Efficacy of Ultra-Early (< 12 h), Early (12-24 h), and Late (>24-138.5 h) Surgery with Magnetic Resonance Imaging-Confirmed Decompression in American Spinal Injury Association Impairment Scale Grades A, B, and C Cervical Spinal Cord Injury."
01/01/2021 - "This randomized, double-blind, placebo-controlled phase 2b/3 study evaluated the efficacy and safety of Rho inhibitor VX-210 (9 mg) in patients after acute traumatic cervical SCI. The study enrolled patients 14-75 years of age with acute traumatic cervical SCIs, C4-C7 (motor level) on each side, and American Spinal Injury Association Impairment Scale (AIS) Grade A or B who had spinal decompression/stabilization surgery commencing within 72 h after injury. "
2. Therapeutics
3. Transplantation
06/29/2017 - "A recent clinical trial demonstrated improved motor function in domestic dogs with spinal injury following autologous OEC transplantation. "
01/01/2021 - "In this study, we assessed the safety and possible outcomes of intrathecal co-transplantation of autologous bone marrow MSC and SC in patients with subacute traumatic complete SCI. Eleven patients with complete SCI (American Spinal Injury Association Impairment Scale (AIS); grade A) were enrolled in this study during the subacute period of injury. "
08/01/1994 - "4. More controlled animal studies are needed (a) to demonstrate efficacy and to evaluate the necessity for immunosuppressive therapy and the overall safety of intraspinal transplantation, (b) to obtain more supporting evidence (e.g., electrophysiologic, histopathologic, MRI, molecular) that would provide insights into ways that transplanted tissue could mediate function, (c) to provide guidance for the procurement, harvesting, preparation, storage, and other logistics related to the use of human cells for transplantation into the spinal cord, (d) to define more thoroughly the cell type(s) that would be most likely to have benefit and the conditions that affect their viability, migration, gene expressions, and proliferation after transplantation, (e) to determine the most optimal time after injury for transplantation, and (f) to clarify patient selection characteristics that might optimize success (i.e., complete vs incomplete injuries, spinal level involved, age of recipient)."
01/01/2022 - "Eight paraplegic participants (American Spinal Injury Association, ASIA: A) were enrolled and treated with vSCT (PEG was applied to the sites of spinal cord transplantation). "
01/01/2019 - "A recent clinical trial proves that autologous olfactory mucosal cell (OMC) transplantation improves locomotion in dogs with naturally occurring spinal injuries comparable to human lesions. "
4. Surgical Decompression
01/01/2020 - "The STASCIS trial documented that surgical decompression within 6 hours of injury leads to an improvement in about 70% of patients by ≥1 American Spinal Injury Association grade. "
11/01/2021 - "We searched PubMed and Embase from the database inception through December 2020 and selected studies comparing the impact of early versus late surgical decompression on neurological recovery as assessed by American Spinal Injury Association Impairment Scale (AIS) for adult patients sustaining tSCI. "
12/01/2022 - "Over a 61-month period, 104 consecutive American Spinal Injury Association Impairment Scale (AIS) grades A-C patients with tCSCI had post-operative MRI to assess the adequacy of surgical decompression. "
10/12/2022 - "We identified a total of 6 predictors with three aspects: (1) clinical characteristics, including age, American Spinal Injury Association (ASIA) Impairment Scale (AIS) at admission, level of injury and baseline ASIA motor score (AMS); (2) MR imaging, mainly including Brain and Spinal Injury Center (BASIC) score; (3) surgical timing, specifically comparing whether surgical decompression was received within 24 h or not. "
01/01/2021 - "Patients who underwent early surgical decompression (n=528) experienced greater recovery than patients who had late decompression surgery (n=1020) at 1 year after spinal injury; total motor scores improved by 23·7 points (95% CI 19·2-28·2) in the early surgery group versus 19·7 points (15·3-24·0) in the late surgery group (MD 4·0 points [1·7-6·3]; p=0·0006), light touch scores improved by 19·0 points (15·1-23·0) vs 14·8 points (11·2-18·4; MD 4·3 [1·6-7·0]; p=0·0021), and pin prick scores improved by 18·3 points (13·7-22·9) versus 14·2 points (9·8-18·6; MD 4·0 [1·5-6·6]; p=0·0020). "
5. Length of Stay
08/01/2023 - "There was no significant difference between the length of operation (145.3 vs 129.8 minutes, P = 0.29), estimated blood loss (303.9 vs 274.4 mL, P = 0.61), improvement in American Spinal Injury Association scale (0.26 vs 0.24 grade, P = 0.85), 30-day return to the operating room (OR; 14.3% vs 6.8%, P = 0.09), 30-day readmission (2.0% vs 6.3% P = 0.24), intensive care unit length of stay (4.6 vs 6.3 days, P = 0.27), hospital length of stay (13.5 days vs 14.2 days, P = 0.72), or 30-day mortality (4.1% vs 7.3%, P = 0.42) for cases performed during hours compared with those after hours, respectively. "
08/01/2008 - "Data from the last 20 patients admitted to the Spinal Injury Care Unit (SICU) who were MRSA positive (study group) have been analysed and then matched with data from 20 patients who were MRSA negative (control group) to compare their total hospital stay and the factors which affect the length of hospital stay. "
11/14/2023 - "ICU and hospital stay were superior in patients treated within 48 hrs for lumbar and thoracic spinal injuries. "
09/14/2023 - "We collected the following data from medical charts: age, sex, living arrangement before injury, acute length of stay (LOS), level of injury on admission, American Spinal Injury Association Impairment Scale (AIS) on admission, Upper Extremity Motor Score (UEMS) on admission, Lower Extremity Motor Score on admission (LEMS), Spinal Cord Independence Measure (SCIM) scores on admission and discharge, and discharge destination. "
09/14/2023 - "The following data were collected from the medical charts: age, sex, acute length of stay (LOS), level of injury, American Spinal Injury Association Impairment Scale (AIS), motor scores of each key muscle, Upper Extremity Motor Score (UEMS), Lower Extremity Motor Score (LEMS), SCIM total scores, and subtotal scores on admission and discharge. "