Spinal Injuries (Spinal Injury)

01/01/1981 - "These studies have demonstrated that the opiate-antagonist naloxone improves blood pressure and functional neurologic recovery after spinal injury. "
11/01/1998 - "Effect of naloxone on the bladder activity of rabbits with acute spinal injury."
06/01/1983 - "These findings confirm the therapeutic benefit of TRH and naloxone in experimental spinal injury and indicate that TRH treatment is most effective. "
01/01/1983 - "Naloxone treatment protected against both moderate (20 min aortic occlusion) and severe (25 min aortic occlusion) degrees of ischemic spinal injury, whereas treatment with M154,129 failed to improve recovery in either model. "
01/30/1981 - "In contrast to saline-treated controls, naloxone treatment significantly improved the hypotension observed after cervical spinal injury. "

05/01/1999 - "Thyrotropin releasing hormone (TRH) is therapeutically effective in experimental and clinical spinal injury. "
03/01/1988 - "The effects of thyrotropin releasing hormone (TRH) were also examined, because this peptide has been shown to have beneficial effects in neuronal ischaemia due to spinal injury. "
10/01/1984 - "Early treatment with thyrotropin-releasing hormone (TRH) at high doses improves neurologic recovery from experimental spinal injury in cats. "
10/01/1984 - "Thyrotropin-releasing hormone in experimental spinal injury: dose response and late treatment."
10/29/1981 - "In contrast, thyrotropin-releasing hormone appears to act in vivo as a partial physiologic opiate antagonist that spares analgesic systems; this activity prompted us to evaluate its effect in spinal injury. "

01/01/1998 - "A comparison between these groups indicates high efficacy of clexane antyembolic prophylactics in patients treated due to spinal injury especially if complicated neurologically."
02/01/2001 - "The present study describes the outcome of a regime of enoxaparin and antithromboembolic stockings in acute spinal injuries irrespective of neurological damage. "
02/01/2001 - "To evaluate the results of thromboembolic prophylaxis using enoxaparin in acute spinal injury patients. "
02/01/2001 - "Prophylaxis of thromboembolism in spinal injuries--results of enoxaparin used in 276 patients."
01/01/1998 - "[Pulmonary embolism as one cause of death after spinal injury--the role of clexane]."

01/01/1984 - "A double-blind randomized, controlled study to investigate the efficacy of cimetidine given in addition to conventional therapy in the prevention of stress ulceration and haemorrhage in patients with acute spinal injury."
01/01/1984 - "Whilst cimetidine has been shown to reduce the incidence of ulceration in patients suffering cranial and thermal injuries, the present study failed to demonstrate a prophylactic effect of cimetidine in the primary prevention of ulcers or erosions in patients with acute spinal injury exceeding that of conventional antacid therapy."
01/01/1984 - "The efficacy of cimetidine, 1.2 and 2.4 g/day, compared to placebo treatment given in addition to conventional therapy, which included antacids, in the prevention of gastroduodenal lesions associated with stress in 105 patients with acute spinal injury was investigated. "
08/01/1983 - "Treatment of established spinal injury-induced gastric erosions in rats with cimetidine and 16,16-dimethyl prostaglandin E2."

11/01/1996 - "Once daily fleroxacin appears to be as safe and effective as twice daily ciprofloxacin and both represent efficacious treatment in complicated urinary infection in spinal injury patients."
11/01/1996 - "The efficacy and safety of fleroxacin and ciprofloxacin were evaluated in a single-centre, prospective, randomised, blinded study of patients with complicated urinary infection in a spinal injury unit. "
11/01/1996 - "Complicated urinary infection in spinal injury patients: fleroxacin compared with ciprofloxacin."

11/01/1996 - "Once daily fleroxacin appears to be as safe and effective as twice daily ciprofloxacin and both represent efficacious treatment in complicated urinary infection in spinal injury patients."
11/01/1996 - "The efficacy and safety of fleroxacin and ciprofloxacin were evaluated in a single-centre, prospective, randomised, blinded study of patients with complicated urinary infection in a spinal injury unit. "
11/01/1996 - "Complicated urinary infection in spinal injury patients: fleroxacin compared with ciprofloxacin."

06/01/1985 - "Changes in substance P and somatostatin in the spinal cord after traumatic spinal injury in the rat."
11/15/1988 - "Thyrotropin releasing hormone (TRH), which has been shown to improve neurologic recovery following cervical contusive spinal injury in cats, has also recently been reported to prevent the neuronal damage produced by the intrathecal (i.t.) administration of the substance P antagonist, spantide. "
06/01/1985 - "Such changes differ from those of a number of other peptides after spinal injury and suggest that substance P and/or somatostatin may play a role in the secondary pathophysiological responses which follow trauma to the spinal cord."

06/01/1981 - "Following spinal injury, the opiate antagonist naloxone selectively elevates plasma dopamine levels, with the dopamine changes significantly correlated with improved cardiovascular function. "
06/01/1981 - "From these data, it is concluded that the cardiovascular effects of naloxone after spinal injury are in part dopamine mediated."
06/01/1981 - "Dopamine partially mediates the cardiovascular effects of naloxone after spinal injury."
01/01/2007 - "Factors that lead to disturbances in the motor activity of the esophagus and the lower esophageal sphincter are primary insufficiency including natal cervical spinal injury, and disbalance of mediators that regulate the motor activity (dopamine, acetylcholine, and serotonin). "

09/01/2006 - "We recently demonstrated that intrathecal bupivacaine before or after acute photochemical spinal injury improved functional outcome in rats. "
04/01/2004 - "Twenty microlitres of intrathecal bupivacaine before or after acute photochemical spinal injury improves hindlimb motor recovery and SEP parameters in rats."

04/01/2010 - "Administration of the lentiviral ERK2 shRNA vector 1 week prior to severe spinal cord contusion injury resulted in a significant improvement in locomotor function (p < 0.05), total tissue sparing (p < 0.05), white matter sparing (p < 0.05), and gray matter sparing (p < 0.05) 6 weeks following severe contusive SCI. Our results suggest that ERK2 signaling is a novel target associated with the deleterious consequences of spinal injury."

01/01/2004 - "This review discusses the consequences of spinal injury, animal models used to study injury and recovery, types of cellular transplants, selection of behavioral and physiological tests of recovery, and ways to test the efficacy of the interventions and to improve transplant-mediated recovery."
08/01/2014 - "The study includes 9 dorsal spine injury patients with American Spinal Injury Association (ASIA) Impairment Scale (AIS) A neurological impairment who underwent de-tethering of the spinal cord followed by cotransplantation with bone marrow stem cells and an olfactory mucosal graft. "
01/01/2013 - "In this bench-top study, we focused on the graft-bone interface under various conditions, using two simulated spinal injury models and common surgical fixation techniques to investigate the effect of implant-mediated compression and contact on the anterior graft. "
06/01/2001 - "The present study indicates that, after a local spinal injury, typical alpha-motoneurons can reinnervate a skeletal muscle by regenerating axons into the permissive microenvironment provided by a PN graft. "
12/01/2014 - "We compared the parameters as follow: the pre- and post-operative American Spinal Injury Association (ASIA) score, lumbo-sacral angle, the height of intervertebral space, visual analogue scale (VAS), and erythrocyte sedimentation rate (ESR), and observed operation time, intraoperative blood loss, and time of bone graft fusion. "

08/01/1994 - "4. More controlled animal studies are needed (a) to demonstrate efficacy and to evaluate the necessity for immunosuppressive therapy and the overall safety of intraspinal transplantation, (b) to obtain more supporting evidence (e.g., electrophysiologic, histopathologic, MRI, molecular) that would provide insights into ways that transplanted tissue could mediate function, (c) to provide guidance for the procurement, harvesting, preparation, storage, and other logistics related to the use of human cells for transplantation into the spinal cord, (d) to define more thoroughly the cell type(s) that would be most likely to have benefit and the conditions that affect their viability, migration, gene expressions, and proliferation after transplantation, (e) to determine the most optimal time after injury for transplantation, and (f) to clarify patient selection characteristics that might optimize success (i.e., complete vs incomplete injuries, spinal level involved, age of recipient)."
01/01/2014 - "Thus, transplantation of olfactory ensheathing cells promoted spinal and neurofunctional recovery in patients with malignant spinal injuries, and this therapeutic method was safe. "
05/01/2013 - "These results suggested transplantation of CD34(+) HUCBCs during the acute phase could promote the functional recovery better than during the subacute phase after SCI by raising blood vessel density, suggesting the possible clinical application for the treatment of spinal injury."
01/01/2012 - "Motor and sensitive improvements were evaluated by means of American Spinal Injury Association (ASIA) grading and Functional Independence Measure (FIM); bladder and urethral function were determined by clinical and urodynamic examination; somatosensory evoked potentials (SSEPs) and motor evoked potentials (MEPs) were used to further confirm the functional recovery following transplantation. "
01/01/2012 - "The recovery of American Spinal Injury Association Impairment Scale (AIS) B and C patients at transplantation was rapid and remarkable, but gradual or limited in AIS A patients. "

01/01/2014 - "Here we evaluated the feasibility, safety and potential efficacy of autologous transplantation of mesenchymal stem cells in subjects with chronic complete SCI. We conducted a phase I, non-controlled study in 14 subjects of both genders aging between 18 to 65 years, with chronic traumatic SCI (>6 months), at thoracic or lumbar levels, classified as American Spinal Injury Association (ASIA) A - complete injury. "

06/01/2015 - "Demographic characteristics (eg, age, sex), time frame over which clinical symptoms of spinal cord dysfunction developed, etiology, length of stay in hospital, level of lesion and American Spinal Injury Association Impairment Scale (AIS) grade, discharge destination, and inpatient mortality. "
09/01/2014 - "Trajectories are based on relationships between growth parameters and patient and injury factors: race, gender, level of education at admission, age at injury, neurological level at discharge, American Spinal Injury Association Impairment Scale (AIS) at discharge, days from injury to first system inpatient rehabilitation admission, rehabilitation length of stay, marital status and etiology. "
07/01/2014 - "Neurologic deterioration, disposition from the emergency department, in-hospital mortality, interfacility transfer time, hospital length of stay, nonroutine discharge, and radiographic evidence of worsening spinal injury. "
09/01/2012 - "Outcome measures included the following: demographic characteristics, American Spinal Injury Association (ASIA) Impairment Scale (AIS), length of stay (LOS), medical complications, accommodation, support services, continence, mobility and Functional Independence Measure (FIM) motor scores. "
12/01/2010 - "Demographic characteristics, etiology, American Spinal Injury Association (ASIA) impairment scale, functional independence measurement (FIM) subgroup scores, length of stay and medical complications in both groups were compared. "

12/01/2010 - "These findings suggest that such patients should be managed at hospitals with specialized acute spinal injury, intensive care and cardiac pacemaker services."
12/01/2010 - "South Australian Tertiary Referral Intensive Care and Spinal Injury Unit. "
10/01/2009 - "Spinal injury resulted in longer intubation times and intensive care stays, but no difference in new injury severity score or outcome. "
06/01/2005 - "Initial presurgical management of spinal injuries with spinal cord damage includes cardiorespiratory intensive care, a precise neurologic examination, and a complete radiological work-up with simple films, computed tomography, and also magnetic resonance imaging if there is a conflict between the imaging results and clinical findings. "
03/01/2001 - "Anaesthetic and intensive care aspects of spinal injury."