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Speech Disorders (Cluttering)

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Acquired or developmental conditions marked by an impaired ability to comprehend or generate spoken forms of language.

Also Known As:

Cluttering; Aprosodias; Aprosodic Speech; Dysglossia; Dyslalia; Rhinolalia; Verbal Fluency Disorders; Clutterings; Dysglossias; Dyslalias; Rhinolalias; Speech, Aprosodic; Verbal Fluency Disorder; Aprosodia

Networked: 140 relevant articles (9 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Headache (Headaches)
2.	Nasal Obstruction
3.	Cleft Palate (Palate, Cleft)
4.	Apraxias (Dyspraxia)
5.	Stuttering (Stammering)

Experts

1.	Geier, Mark R: 6 articles (08/2006 - 06/2003)
2.	Geier, David A: 6 articles (08/2006 - 06/2003)
3.	Shriberg, Lawrence D: 2 articles (12/2014 - 01/2013)
4.	Maassen, B: 2 articles (01/2014 - 01/2011)
5.	Terband, H: 2 articles (01/2014 - 01/2011)
6.	Eysholdt, U: 2 articles (03/2011 - 01/2008)
7.	Schuster, M: 2 articles (03/2011 - 01/2008)
8.	Maier, A: 2 articles (03/2011 - 01/2008)
9.	Abdolnejad, Shawbo: 1 article (08/2015)
10.	Karimi, Gelavizh: 1 article (08/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Speech Disorders:

1.	Betamethasone (Celestone)FDA Link 01/01/2014 - "A statistically significant improvement in speech according to a speech disorders subscale was observed with betamethasone. "
2.	Marker X syndromeIBA 01/01/1986 - "Cluttering may be helpful in identifying the fra(X) syndrome in a male who is not retarded." 01/01/1986 - "Other aspects of cluttering including attentional problems, hyperactivity, motor delays and reading difficulties are commonly seen in the fra(X) syndrome. "
3.	amsonic acid (DAS)IBA 01/01/2005 - "Error inconsistency is often cited as a characteristic of children with speech disorders, particularly developmental apraxia of speech (DAS); however, few researchers operationally define error inconsistency and the definitions that do exist are not standardized across studies. " 07/01/2002 - "After completing this paper, readers should be able to (a) identify key epidemiological findings for the three speech phenotypes that were discussed (DAS, speech delay, and stuttering); (b) summarize the findings of the behavioral genetic studies of speech disorders that were presented; (c) identify four specific challenges that may impede future molecular genetic studies of these phenotypes; (d) describe the methodological sequence that led to the discovery of the FOXP2 gene; and (e) summarize the two research strategies that were presented to potentially reduce sample heterogeneity for future molecular genetics research."
4.	Carbon MonoxideIBA 01/01/2015 - "There is growing evidence that motor and speech disorders co-occur during development. " 10/01/2014 - "Using Mplus, genetic analyses using liability threshold models were conducted for both phenotypes, for their co-morbidity, and for specific hoarding symptoms (cluttering, discarding and acquiring). " 11/01/2003 - "Chi-square analyses revealed that males were more likely to exhibit co-occurring speech disorders than females, especially articulation and phonology. " 01/01/1994 - "Forty to 50% of these patients showed co-ordination disturbances; more than 20% had speech disorders and cranial nerve deficits. " 11/01/2003 - "This study used a mail survey to determine the (a) percentage of children who stutter with co-occurring non-speech disorders, speech disorders, and language disorders, and (b) frequency, length of sessions, and type of treatment services provided for children who stutter with co-occurring disorders. "
5.	Sodium Glutamate (Accent)IBA 01/01/1962 - "[Interverbal and intraverbal acceleration in cluttering (experimental phonetic studies on speech accent in cluttering)]." 02/01/2013 - "Foreign accent syndrome (FAS) is a rare condition which is placed in the mildest end of the spectrum of speech disorders. " 01/01/1989 - "Comments on the accent method of treating voice and speech disorders]." 10/01/2012 - "Characterizing intonation deficit in motor speech disorders: an autosegmental-metrical analysis of spontaneous speech in hypokinetic dysarthria, ataxic dysarthria, and foreign accent syndrome."
6.	Lysergic Acid Diethylamide (LSD)IBA 08/01/2003 - "The study groups were made up of patients suffering from language and speech disorders (LSD), specific learning difficulties (SLD), attention deficit hyperactivity disorder (ADHD), and a fourth group with mixed neuropsychological symptoms (MNS). "
7.	Chlordiazepoxide (Elenium)FDA LinkGeneric 02/01/1963 - "[Clinical and experimental studies on the effectiveness of chlordiazepoxide in speech disorders]."
8.	Silver Sulfadiazine (SSD)FDA LinkGeneric 12/01/2014 - "Both subgroups were consistent with classes of SSD in the Speech Disorders Classification System (SDCS; Shriberg et al., 2010a). " 09/01/2014 - "The reader will be able to: (1) describe the potential role of auditory feedback control in developmental speech disorders (SSD); (2) identify the neural control subsystems involved in feedback based speech motor control; (3) describe the differences between compensation and adaptation for perturbed auditory feedback; (4) explain why auditory-motor integration may play a key role in SSD." 01/01/2014 - "The reader will be able to: (1) identify the difficulties in studying disordered speech motor development; (2) describe the differences in speech motor characteristics between SSD and subtype CAS; (3) describe the different types of learning that occur in the sensory-motor system during babbling and early speech acquisition; (4) identify the neural control subsystems involved in speech production; (5) describe the potential role of auditory self-monitoring in developmental speech disorders." 01/01/2013 - "Three specific paediatric SSD classification systems; the aetiologic-based Speech Disorders Classification System, the descriptive-linguistic Differential Diagnosis system, and the processing-based Psycholinguistic Framework are identified as potentially useful in classifying children with SSD into homogeneous subgroups. " 01/01/2011 - "The reader will be able to: (1) describe the development of speech motor control and explain the role of functional synergies/coordinative structures; (2) explain the measurement of the stability and composition of speech movements; (3) identify the difficulties in studying disordered speech motor development; (4) describe the differences in speech motor characteristics between SSD and subtype CAS; (5) describe the potential role of motor control strategies in developmental speech disorders."
9.	DNA (Deoxyribonucleic Acid)IBA 01/01/2014 - "We employed a large-insert (7-11 kb) paired-end tag sequencing technology (DNA-PET) to systematically analyze genome of four patients harbouring cytogenetically defined ABCR with neurodevelopmental symptoms, including developmental delay (DD) and speech disorders. " 06/01/2002 - "Neurologic features associated with major ataxia, speech disorders, and PML were documented by cranial magnetic resonance imaging showing typical features in the cerebellum and proven by polymerase chain reaction (PCR) detection of JCV DNA in the cerebrospinal fluid. " 01/01/2009 - "Mutational and demographic processes contribute to the cluttering of eukaryotic genomes and transcriptional networks with "junk" DNA and spurious DNA binding sites. "
10.	Diphtheria-Tetanus-acellular Pertussis Vaccines (Tripedia)FDA Link 06/01/2003 - "The male/female ratio indicated that autism (17) and speech disorders (2.3) were reported more in males than females after thimerosal-containing DTaP vaccines, whereas mental retardation (1.2) was more evenly reported among male and female vaccine recipients. " 04/01/2005 - "Phase one showed significantly increased risks for autism, speech disorders, mental retardation, personality disorders, and thinking abnormalities reported to VAERS following thimerosal-containing DTaP vaccines in comparison to thimerosal-free DTaP vaccines. " 06/01/2003 - "Specifically, an analysis of the Vaccine Adverse Events Reporting System (VAERS) database showed statistical increases in the incidence rate of autism (relative risk [RR] = 6.0), mental retardation (RR = 6.1), and speech disorders (RR = 2.2) after thimerosal-containing diphtheria, tetanus, and acellular pertussis (DTaP) vaccines in comparison with thimerosal-free DTaP vaccines. "

Therapies and Procedures

1.	Speech Therapy (Therapy, Speech) 01/01/1996 - "In 58 children (14%) with rhinolalia aperta not being improved by speech therapy for at least 1 year, velopharyngoplasty with a cranially based pharyngeal flap was performed. " 01/01/1995 - "In 58 children (14%) with rhinolalia aperta, which had not been improved after one year of speech therapy, velopharyngoplasty with a cranial based pharyngeal flap was performed. " 11/01/1994 - "Fifty-eight children (14%) with rhinolalia aperta were not improved by speech therapy and required velopharyngoplasties, using a cranial-based pharyngeal flap. " 09/12/1975 - "In the field of linguodental dyslalia, reference is made to improvement in speech therapy techniques and the hope is expressed that these may be extended to the management of other forms." 03/01/1988 - "[Clinical study on speech disorders and speech therapy of ankyloglossia]."
2.	Aftercare (After-Treatment) 09/01/2010 - "Evaluation of auditory processing before and after treatment in patients with speech disorders." 10/01/2004 - "Speech therapy was carried out for patients with speech disorders after pharyngoplasty, and the comparison of speech articulation before and after treatment, was done to evaluate the new method. " 01/01/2008 - "For adults with speech disorders, automatic speech recognition may serve as a valuable tool to assess global speech outcome after treatment of oral squamous cell carcinoma objectively and quantitatively for clinical and research purposes." 12/01/2005 - "All the parameters of symptoms were improved after treatment, including nasal obstruction, nasal secretions, itchy feeling of the nose, closed rhinolalia and headache. " 06/01/2011 - "Five hours after treatment the patient presented with sudden headache, nausea and speech disorders and a CT scan revealed intracerebral and subarachnoid hemorrhage. "
3.	Psychology Biofeedback (Biofeedback) 08/01/1996 - "A case of motor aprosodia treated with voice pitch biofeedback and modelling of affective communication is presented. " 08/01/1996 - "Treatment of motor aprosodia with pitch biofeedback and expression modelling." 06/01/1980 - "Thus far, results of experiments utilizing biofeedback techniques have suggested positive effects in the remediation of speech disorders. " 06/01/1980 - "The implementation of biofeedback procedures represents a new approach to clinical management of speech disorders. " 06/01/1977 - "Implications for clinical endeavors are detailed and data are presented to illustrate the power of biofeedback in managing speech disorders in the profoundly hearing impaired, when those disorders are partially respiratory based."
4.	Drug Therapy (Chemotherapy) 01/01/2002 - "Additionally, pharmacotherapy and biofeedback have been found useful in the treatment of aprosodia and associated features." 01/01/1970 - "A contribution to pharmacotherapy of stuttering and cluttering."
5.	Neurofeedback 03/01/2010 - "The positive outcomes of decreased symptoms of Asperger's and ADHD (including a decrease in difficulties with attention, anxiety, aprosodias, and social functioning) plus improved academic and intellectual functioning, provide preliminary support for the use of neurofeedback as a helpful component of effective intervention in people with AS."