Sparganosis

Infection of animals, including fish and man, with a developmental stage of Diphyllobothrium. This stage has recently been referred to as a plerocercoid but the name sparganum has persisted. Therefore, infection of fish or other animals with the plerocercoid larvae is sparganosis. Fish-eating mammals, including man, are the final hosts.

Also Known As:

Networked: 59 relevant articles (4 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cysticercosis
2.	Echinococcosis (Hydatid Cysts)
3.	Schistosomiasis (Bilharziasis)
4.	Paragonimiasis
5.	Infection

Experts

1.	Cui, Jing: 8 articles (06/2015 - 06/2011)
2.	Wang, Zhong Quan: 7 articles (06/2015 - 06/2011)
3.	Liu, Li Na: 5 articles (06/2015 - 07/2013)
4.	Jiang, Peng: 4 articles (06/2015 - 06/2011)
5.	Kong, Yoon: 4 articles (01/2015 - 09/2002)
6.	Yang, Hyun-Jong: 4 articles (01/2015 - 06/2004)
7.	Yamasaki, Hiroshi: 4 articles (09/2014 - 12/2011)
8.	Qi, Xin: 3 articles (06/2015 - 02/2012)
9.	Zhang, Xi: 3 articles (06/2015 - 09/2014)
10.	Liu, Ruo Dan: 3 articles (06/2015 - 05/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sparganosis:

1.	AntigensIBA 06/01/2015 - "The rSeCP is a potential diagnostic antigen for sparganosis." 06/01/2015 - "The sensitivity of rSeCP-ELISA and ES antigen ELISA was 100% when performed on sera of patients with sparganosis. " 02/01/2015 - "The results showed that the rSeCP might be a potential candidate antigen for early and specific serodiagnosis of sparganosis. " 09/01/2014 - "It is suggested that the rSmAP might be a potential candidate antigen for serodiagnosis of sparganosis." 09/01/2014 - "ELISA with rSmAP antigen or sparganum ES antigens were evaluated for the serodiagnosis of sparganosis. "
2.	Cysteine Proteases (Cysteine Protease)IBA 02/01/2014 - "Diagnostic efficacy of a recombinant cysteine protease of Spirometra erinacei larvae for serodiagnosis of sparganosis." 06/01/2015 - "The aim of this study was to characterize Spirometra erinaceieuropaei cysteine protease (SeCP) and to evaluate its potential application for serodiagnosis of sparganosis. " 06/01/2015 - "Characterization of Spirometra erinaceieuropaei Plerocercoid Cysteine Protease and Potential Application for Serodiagnosis of Sparganosis." 02/01/2015 - "Serodiagnosis of sparganosis by ELISA using recombinant cysteine protease of Spirometra erinaceieuropaei spargana." 02/01/2015 - "The Spirometra erinaceieuropaei cysteine protease (SeCP) gene encoding a 36 kDa protein was expressed in Escherichia coli, and the potential of recombinant SeCP protein (rSeCP) as an antigen for the serodiagnosis of sparganosis was investigated by ELISA and compared with those of ELISA with sparganum excretory-secretory (ES) antigens. "
3.	Praziquantel (Biltricide)FDA Link 06/01/2014 - "Oral praziquantel is effective for the treatment of sparganosis mansoni, although its course of therapy may need to be repeated. " 05/01/2013 - "High-dose praziquantel therapy for cerebral sparganosis." 01/01/2011 - "Praziquantel is an alternative treatment for sparganosis in surgically-unresectable cases." 08/01/2013 - "Thus, the patient was first diagnosed as sparganosis; however, new migratory swellings occurred after treatment with praziquantel for 3 days. " 03/01/2013 - "In addition, larval cestode infections, particularly hydatid disease and sparganosis, are not successfully treated by praziquantel. "
4.	Albendazole (Albenza)FDA Link 02/29/2012 - "The results indicated albendazole has no obvious efficacy for treating sparganosis in mice."
5.	Immunoglobulin G (IgG)IBA 12/01/1989 - "The present study is intended to observe the chronologic changes of experimental sparganosis by histopathological observation and detection of circulating anti-sparganum IgG antibody using ELISA. " 02/01/2014 - "Moreover, in experimentally infected mice, the sensitivity and specificity of both ELISA assays were 100% for the detection of anti-sparganum IgG. It is suggested that the rSepCp-1 protein-based ELISA could provide a highly sensitive and specific assay for the diagnosis of sparganosis. " 09/01/2000 - "mansoni plerocercoid is the main antigenic component inducing IgG antibody response in early stage of experimental sparganosis and for specific IgG subclass reactions in human sparganosis." 09/01/2000 - "When 69 patients sera of human sparganosis were examined for their IgG subclass responses, IgG4 levels showed the highest reaction which was followed by IgG1. " 09/01/2000 - "IgG antibody responses in early experimental sparganosis and IgG subclass responses in human sparganosis."
6.	AntibodiesIBA 09/01/2014 - "Development of a rapid diagnostic kit that uses an immunochromatographic device to detect antibodies in human sparganosis." 03/01/1992 - "When polyclonal antibodies such as BALB/c mouse serum immunized with crude saline extract of sparganum or confirmed sparganosis sera were reacted as primary antibodies, the positive chromogen (3-amino, 9-ethylcarbazole) reactions were recognized at syncytial tegument, tegumental cells, muscle and parenchymal cells and lining cells of excretory canals. " 12/01/2013 - "Sparganosis was diagnosed by demonstration of the sparganum in histopathological sections of surgically resected tissues and also by the presence of serum IgG antibodies by ELISA. " 06/01/2011 - "We conducted a study of serodiagnosis of experimental sparganum infections of mice and human sparganosis by enzyme-linked immunosorbent assay (ELISA) using excretory-secretory (ES) antigens of Spirometra mansoni spargana and compared the sensitivity and specificity of crude and ES antigens for detecting the specific anti-sparganum IgG antibodies. "
7.	AngiostrongyliasisIBA 01/01/2002 - "For discharge diagnosis, neurocysticercosis accounted for 92.2% (106/115), cerebral paragonimiasis 3.5% (4/115), sparganosis 2.6% (3/115), and angiostrongyliasis cantonensis and gnathostomiasis 0.9% (1/115) each. " 01/01/2010 - "In this review, we focus primarily on food-borne helminthiases that are endemic and often emerging in Southeast Asia and the Far East, namely angiostrongyliasis, gnathostomiasis, sparganosis, paragonimiasis and cysticercosis. " 11/01/2002 - "In the present study, we review the seven most common parasitic diseases of the CNS: (i) cysticercosis, (ii) neuroschistosomiasis, (iii) paragonimiasis, (iv) angiostrongyliasis, (v) hydatid disease, (vi) sparganosis and (vii) gnathostomiasis. "
8.	feralIBA 06/12/2001 - "The primary objective of this study was the determination of the prevalence of gross sparganosis in Florida county of origin in slaughtered feral swine. " 06/01/2012 - "The occurrence of the cestode in feral cats coupled with factors that are unique to Grand Cayman makes this island the ideal location for sporadic cases of human sparganosis." 06/01/2012 - "The occurrence of platynosomiasis and intestinal sparganosis is described in feral cats from Grand Cayman, Cayman Islands. " 06/12/2001 - "Overall prevalence of sparganosis in Florida feral swine was 6.9%. " 06/12/2001 - "Tracebacks to county of origin were conducted for Florida feral swine with and without gross sparganosis. "
9.	tebufenozide (Mimic)IBA 06/01/2012 - "Pulmonary sparganosis mansoni shares some clinical and radiologic similarities that mimic other common pulmonary pathogens. " 08/01/2011 - "Sparganosis may mimic an intramedullary tumor of the spinal cord and should be considered in the differential diagnosis of a cervical cord mass with an uncertain course." 12/01/2008 - "Cerebral sparganosis can closely mimic tuberculoma or neoplastic lesions. "
10.	Proteins (Proteins, Gene)IBA 05/01/2014 - "erinaceieuropaei soluble proteins recognized by early infection sera might be developed as diagnostic reagent for early detection of sparganosis." 07/01/2013 - "mansoni ES proteins recognized by early infection sera might be the early diagnostic antigens for sparganosis."

Therapies and Procedures

1.	Cystectomy 05/01/2000 - "A partial cystectomy was performed on the female patient, and the histological diagnosis was Sparganosis mansoni. "
2.	Transplantation (Transplant Recipients) 12/01/2012 - "We report here a case of inguinal sparganosis, initially regarded as myeloid sarcoma, diagnosed in a patient undergone allogeneic hematopoietic transplantation (HSCT). "
3.	Orchiectomy (Orchidectomy) 07/01/2014 - "This case was misdiagnosed as testicular tumor and underwent orchiectomy, but was diagnosed as testicular sparganosis by histopathology. "
4.	Debridement 01/01/2004 - "Recently, we experienced a case of Fournier's gangrene associated with sparganosis in the scrotum, which was treated with antibiotics and extensive debridement including removal of a white, flat, shiny sparganum worm."
5.	Aftercare (After-Treatment) 08/01/2013 - "Thus, the patient was first diagnosed as sparganosis; however, new migratory swellings occurred after treatment with praziquantel for 3 days. "