Sorbitol (Yal)

A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.

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Networked: 944 relevant articles (40 outcomes, 74 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Obrosova, Irina G: 9 articles (06/2012 - 01/2002)
2.	Kador, Peter F: 7 articles (02/2014 - 04/2003)
3.	Blessing, Karen: 6 articles (02/2014 - 08/2004)
4.	Stavniichuk, Roman: 4 articles (06/2012 - 03/2011)
5.	Oates, Peter J: 4 articles (01/2010 - 01/2005)
6.	Bril, Vera: 4 articles (07/2008 - 05/2004)
7.	Karch, Helge: 4 articles (07/2007 - 09/2002)
8.	Petrash, J Mark: 3 articles (06/2015 - 01/2008)
9.	Zhang, Peng: 3 articles (02/2014 - 01/2011)
10.	Drel, Viktor R: 3 articles (06/2012 - 10/2007)

Related Diseases

1.	Hepatic Encephalopathy 08/01/2002 - "Hepatic plasma flow was estimated in patients with acute liver failure after development of hepatic encephalopathy grade III, by the use of liver vein catheterization and continuous infusion of sorbitol. " 06/01/1981 - "Sorbitol solution has been used to a control substance of evaluating the efficacy of lactulose therapy for hepatic encephalopathy (HE). " 03/01/1998 - "Hepatic plasma flow estimated according to Fick's principle in patients with hepatic encephalopathy: evaluation of indocyanine green and D-sorbitol as test substances." 09/01/1984 - "Portal systemic encephalopathy-sorbitol--a potential replacement for lactulose." 05/01/1983 - "These findings indicate that both sorbitol and lactulose are extensively fermented by the colonic flora and that the possibility of replacing lactulose with the much cheaper sorbitol in the treatment of portal-systemic encephalopathy ought to be investigated. "
2.	Hyperglycemia 07/10/2015 - "Hyperglycemia Promotes Schwann Cell De-differentiation and De-myelination via Sorbitol Accumulation and Igf1 Protein Down-regulation." 11/01/2007 - "Thus we hypothesized that elevated level of sorbitol contributes to the development of hyperglycemia-induced dysfunction of microvessels. " 02/01/2003 - "Sorbitol levels in aortic endothelial cells and within the smooth muscle layer were significantly increased with hyperglycemia. " 02/01/2002 - "The process of sorbitol accumulation is more evident than glycation in the initial stage of hyperglycemia. " 05/01/1996 - "Stepwise regression analysis highlighted the fact that the hyperglycemia-dependent increase in RBC sorbitol was significantly influenced by GSH concentrations (partial F = 14.6, P < .001). "
3.	Poisoning 02/01/2015 - "This exploratory study assessed the effectiveness of premixed AC-sorbitol as a treatment for OP poisoning. " 01/01/2015 - "Additionally, the introduction of WOx into Ru/CNTs significantly improved the hydrogenolysis activities, and a complete conversion of sorbitol with up to 60.2% 1,2-PD and EG yields was obtained on RuWOx/CNTs catalyst upon addition of Ca(OH)2. Stability study showed that this catalyst was highly stable against leaching and poisoning and could be recycled several times. " 07/01/1989 - "[Efficacy of treatment with charcoal diluted in 70% sorbitol during acute poisonings]." 03/01/1993 - "Based on an evaluation of risks and benefits, any activated charcoal product that does not contain sorbitol appears to be a suitable choice for treating poisoning victims." 01/01/1985 - "Activated charcoal-sorbitol mixture is used for the treatment of acute poisoning. "
4.	Fibrosis (Cirrhosis) 03/15/2004 - "The functional hepatic flow (FHF) and total hepatic flow (THF) were determined by means of modified hepatic clearance of D-sorbitol combined with duplex doppler color sonography in 20 patients with cirrhosis and 10 healthy volunteers. " 03/15/2004 - "D-sorbitol total clearance was significantly reduced in cirrhosis compared to control (P<0.01), while D-sorbitol renal clearance was significantly increased in cirrhosis (P<0.05). " 03/15/2004 - "FHF, evaluated by means of the D-sorbitol clearance, was significantly reduced in patients with cirrhosis in comparison to controls (764.74+/-167.91 vs 1195.04+/-242.97 mL/min, P<0.01). " 04/01/1989 - "Sorbitol clearance: shift from flow-limitation in controls to enzyme-flow dependence in cirrhosis." 10/01/1987 - "Ten normal subjects, 10 patients with cirrhosis and 12 cirrhotics with surgical portacaval shunts were studied after oral and intravenous administration of a 2 g dose of sorbitol. "
5.	Dental Plaque 04/01/2001 - "This study was conducted to find out whether sorbitol inhibits the sugar metabolism of Streptococcus mutans in vitro and the acid production in dental plaque in vivo. " 06/01/1991 - "Clinical studies in Sweden have shown that the proportion of sorbitol-utilizing strains of Streptococcus sanguis increases in dental plaque from individuals using sorbitol-containing products for prolonged periods. " 04/01/2001 - "Sorbitol also inhibited the acid production in dental plaque in vivo. " 04/01/2001 - "Inhibitory effect of sorbitol on sugar metabolism of Streptococcus mutans in vitro and on acid production in dental plaque in vivo." 12/01/1994 - "The initial steps of sorbitol catabolism were studied in 4 strains of Actinomyces naeslundii and Actinomyces viscosus that had been isolated from human dental plaque. "

Related Drugs and Biologics

1.	Lactulose (Duphalac)
2.	Xylitol
3.	Glucose (Dextrose)
4.	Aldehyde Reductase (Aldose Reductase)
5.	lactitol
6.	Chewing Gum (Chewing Gums)
7.	Fructose
8.	Mannitol (Osmitrol)
9.	sorbinil
10.	ONO 2235 (epalrestat)

Related Therapies and Procedures

1.	Enema (Enemas)
2.	Toothbrushing
3.	Dental Care
4.	Parenteral Nutrition
5.	Induced Heart Arrest (Cardioplegia)