Somatomedins (Somatomedin)

Insulin-like polypeptides made by the liver and some fibroblasts and released into the blood when stimulated by SOMATOTROPIN. They cause sulfate incorporation into collagen, RNA, and DNA synthesis, which are prerequisites to cell division and growth of the organism.

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Networked: 1089 relevant articles (8 outcomes, 95 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pollak, Michael N: 9 articles (01/2015 - 10/2003)
2.	Yu, Herbert: 8 articles (04/2011 - 08/2002)
3.	Holly, Jeff M P: 7 articles (01/2013 - 07/2003)
4.	Gunnell, David: 7 articles (01/2013 - 01/2005)
5.	Hankinson, Susan E: 7 articles (09/2007 - 01/2003)
6.	Miyamoto, Shin'ichi: 6 articles (01/2014 - 09/2004)
7.	Gunnell, D: 6 articles (01/2007 - 04/2000)
8.	Gao, Yu-Tang: 6 articles (01/2007 - 07/2002)
9.	Flyvbjerg, Allan: 6 articles (10/2005 - 05/2003)
10.	Pollak, M: 6 articles (08/2001 - 04/2000)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 07/01/2011 - "Previous studies have suggested that pregnancy measures of insulin-like growth factors (IGFs) may be related to breast cancer risk in mothers. " 01/01/2008 - "The present study aimed to evaluate the importance of active osteoclasts and bone-derived insulin-like growth factors (IGFs) for the survival and growth of breast cancer cells in bone. " 01/01/2003 - "Evidence from epidemiology studies of the association of insulin-like growth factors with breast cancer risk has been rapidly accruing over the past few years, indicating a potential role of IGFs in breast carcinogenesis. " 01/01/1994 - "These questions will be addressed in the context of this laboratory's studies on insulin-like growth factors, as these molecules show marked differences in stromal expression between benign and malignant breast tissue and thus provide a useful paradigm for investigations into the paracrine environment of an evolving breast tumor." 04/01/2011 - "Let-7a regulation of insulin-like growth factors in breast cancer."
2.	Prostatic Neoplasms (Prostate Cancer) 02/01/2012 - "Serum insulin-like growth factors and mortality in localised and advanced clinically detected prostate cancer." 09/01/2004 - "Advanced prostate cancer frequently involves the bone that has the largest content of insulin-like growth factors (IGFs). " 09/01/2004 - "Growth inhibition of human prostate cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice by a ligand-specific antibody to human insulin-like growth factors." 03/01/2002 - "et al., Insulin-like growth factors and prostate cancer: a population-based case-control study in China. " 08/15/2001 - "Several lines of investigation have suggested that insulin-like growth factors (IGFs) are involved in the biology of prostate cancer, but little is known about their relevance to progression to androgen independence. "
3.	Neoplasms (Cancer) 02/10/2004 - "hGHRH antagonists with improved efficacy could be useful for treatment of cancers that depend on insulin-like growth factors or GHRH." 12/01/2010 - "A growing number of studies have demonstrated an association between serum levels of insulin-like growth factors (IGFs) and IGF binding protein-3 (IGFBP-3) and increased risk for various cancers. " 08/01/2008 - "Many studies support a role for insulin-like growth factors (IGFs) in the regulation of tumor cell biology. " 04/01/2007 - "Several studies have suggested that insulin-like growth factors (IGF) are related to cancer risk. " 06/01/2006 - "A growing number of studies have demonstrated an association between insulin-like growth factors (IGF) serum levels and increased risk for various cancers. "
4.	Uremia 10/01/1984 - "These studies suggest that decreased circulating somatomedin activity and impaired growth in uremia may reflect the accumulation of a circulating peptide inhibitor that would normally be cleared by the kidneys. " 10/01/2004 - "The role of the muscle insulin-like growth factors (IGFs), a principal anabolic system that is involved in protein synthesis and that has downregulation that is implicated in muscle loss in animal models of uremia, has previously not been assessed in vivo in HD patients. " 10/01/1978 - "Somatomedin's levels in uremia are variously reported. " 11/19/1976 - "Further efforts are necessary to identify the inhibitor(s) of somatomedin activity in uremia." 11/01/1986 - "Somatomedin levels measured by radioreceptor assay (RRA) or RIA on acid-ethanol-extracted or unextracted serum from patients with uremia are quite variable relative to normal values. "
5.	Body Weight (Weight, Body) 09/01/1987 - "After long-term administration of nitrate a significant decrease of serum somatomedin activity was found which also showed a positive correlation with a decrease of body weight gain." 06/01/1983 - "The plasma levels of immunoreactive somatomedins A were negatively correlated to the plasma GH concentrations but positively correlated to the body weight. " 09/01/1982 - "Fetal plasma somatomedin activity, measured by fetal cartilage assay, showed a significant positive correlation with both body weight and length. " 11/05/1981 - "The results presented indicate that bovine GH and T3 treatment affect the body weight increase in dwarf mice according to two mechanisms: (1) T3 increases the number of GH receptors in liver and probably GH content and secretion in pituitary; (2) GH increases the synthesis of somatomedins in liver. " 07/01/1981 - "Cartilage response to plasma, plasma somatomedin activity, body weight and length were measured in rats from 15 days of fetal age to 37 days postnatally. "

Related Drugs and Biologics

1.	Insulin-Like Growth Factor I (IGF-1)
2.	Growth Hormone (Somatotropin)
3.	Proteins (Proteins, Gene)
4.	Leptin
5.	Gonadal Steroid Hormones (Sex Hormones)
6.	DNA (Deoxyribonucleic Acid)
7.	Cytochrome P-450 CYP1A1 (CYP1A1)
8.	Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)
9.	Quercetin
10.	Oxidoreductases

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Caloric Restriction
3.	Liver Transplantation
4.	Transplantation (Transplant Recipients)
5.	Aftercare (After-Treatment)