Sodium Salicylate (Salicylate, Sodium)

A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120)

Also Known As:

Networked: 385 relevant articles (18 outcomes, 35 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Lin: 7 articles (05/2015 - 05/2005)
2.	Salvi, Richard J: 5 articles (01/2015 - 01/2012)
3.	Luo, Bin: 4 articles (01/2015 - 05/2006)
4.	Kang, Ho Sung: 4 articles (05/2008 - 08/2003)
5.	Salvi, Richard: 3 articles (09/2015 - 08/2010)
6.	Sun, Wei: 3 articles (01/2015 - 08/2010)
7.	Stolzberg, Daniel: 3 articles (10/2013 - 07/2012)
8.	Giacca, Adria: 3 articles (04/2013 - 11/2007)
9.	Kim, Sun Mi: 3 articles (05/2008 - 11/2005)
10.	Han, Song Iy: 3 articles (05/2008 - 11/2005)

Related Diseases

1.	Pain (Aches) 04/01/2007 - "It was concluded that sodium salicylate iontophoresis was effective in the management of hip pain in patients with SCD. " 06/01/2010 - "A pilot study showed an improvement in pain from OA at the first carpometacarpal joint after injection of such areas with 0.5% sodium salicylate or saline, an inexpensive treatment that can be administered by general practitioners and nurses. " 05/31/2005 - "Sodium salicylate is one of the nonsteroidal antiinflammatory drugs and is clinically used for antiinflammation and chronic pain relief. " 02/01/1984 - "Sodium salicylate, 537 mg and 1074 mg were compared in a double-blind cross-over study in 24 patients with post-operative pain following removal of impacted lower third molars. " 02/01/1984 - "The efficacy and pharmacokinetics of sodium salicylate in post-operative dental pain."
2.	Insulin Resistance 07/26/2013 - "Treatment of OSMRβ(-/-) mice with an anti-inflammatory agent, sodium salicylate, improved insulin resistance. " 02/01/2007 - "Anti-inflammatory reagent, sodium salicylate, partial improved insulin resistance of aged L-SOCS3 cKO mice, suggesting that enhanced inflammatory status is associated with the phenotype of these mice. " 08/01/2010 - "In the present study, we investigated the effects of sodium salicylate on FFAs-induced insulin resistance and on oxidative stress in liver. " 11/01/2007 - "In the present study, we wished to test the hypothesis that sodium salicylate, which inhibits IKKbeta , prevents hepatic insulin resistance caused by short-term elevation of FFA. " 01/01/2015 - "Sodium salicylate reduced insulin resistance in the retina of a type 2 diabetic rat model."
3.	Inflammation 07/01/2015 - "The effect on inflammation of the highest dose of extract was comparable to sodium salicylate. " 06/01/2015 - "Although sodium salicylate decreased 10,12 CLA-mediated increases in markers of inflammation in WAT, it did not affect other outcomes. " 01/01/2014 - "To suppress the inflammatory response, sodium salicylate, which inhibits nuclear factor-κB activity, was used to prepare the standard curve for anti-inflammation. " 07/15/2013 - "To investigate the role of inflammation-associated pathways in these homeorhetic adaptations, we treated cows with the nonsteroidal anti-inflammatory drug sodium salicylate (SS) for the first 7 days of lactation. " 09/01/1993 - "Gross mammary inflammation was not reduced by salicylate infusion, nor did sodium salicylate prevent increased milk SCC or BSA concentrations in milk, although treatment tended to decrease the magnitude of these responses. "
4.	Rheumatic Diseases (Rheumatism) 01/01/1954 - "[Study of the importance of administration of sodium salicylate in acute myocardial lesions appearing during attacks of specific cardio-articular rheumatism]." 05/01/1970 - "[Effect of mud applications and their combination with sodium salicylate on the cardiac function in modeling of rheumatism]." 12/21/1964 - "[SODIUM SALICYLATE AND RHEUMATISM]." 02/17/1955 - "[Modification of capillary permeability in rheumatism treated with sodium salicylate: application of Landis test; personal case reports]." 10/18/1952 - "[Use of sodium salicylate in therapy of rheumatism]."
5.	Fever (Fevers) 02/01/1998 - "The hyperthermia is apparently a result of the activation of the COX-PGE2 pathway because it is blocked by the anti-pyretic sodium salicylate. " 07/01/1996 - "That the hyperthermia can be blocked with administration of sodium salicylate suggests that the hyperthermia is a fever. " 03/01/1989 - "Infusion of sodium salicylate (50.0 or 100.0 micrograms/microliters) into the ventral septal area (VSA) of the rat brain suppressed Prostaglandin-E1-induced hyperthermia. " 08/01/1988 - "Pretreatment with sodium salicylate before inducing hyperthermia led to a variable rise in alpha M FP. " 03/01/1987 - "3. The fever index (degrees C h for 1.0 h) during the infusion of sodium salicylate was reduced 66% below that of control infusions (P less than 0.01). "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Aspirin (Acetylsalicylic Acid)
3.	Glucose (Dextrose)
4.	Cortisone
5.	Formaldehyde (Formol)
6.	Amphotericin B (Amphotericin)
7.	Hydroxyl Radical
8.	Sodium
9.	Histamine (Histamine Dihydrochloride)
10.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Transcutaneous Electric Nerve Stimulation (TENS)
3.	Analgesia
4.	Intravenous Injections
5.	Intravenous Infusions