Sodium Nitrite

Nitrous acid sodium salt. Used in many industrial processes, in meat curing, coloring, and preserving, and as a reagent in ANALYTICAL CHEMISTRY TECHNIQUES. It is used therapeutically as an antidote in cyanide poisoning. The compound is toxic and mutagenic and will react in vivo with secondary or tertiary amines thereby producing highly carcinogenic nitrosamines.

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Networked: 382 relevant articles (21 outcomes, 34 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gladwin, Mark T: 8 articles (12/2014 - 03/2004)
2.	Patel, Rakesh P: 8 articles (08/2012 - 03/2004)
3.	Kevil, Christopher G: 7 articles (02/2014 - 05/2005)
4.	Pinheiro, Lucas C: 6 articles (10/2015 - 07/2011)
5.	Tanus-Santos, Jose E: 6 articles (10/2015 - 07/2011)
6.	Montenegro, Marcelo F: 6 articles (10/2015 - 07/2011)
7.	Amaral, Jefferson H: 6 articles (10/2015 - 07/2011)
8.	Lefer, David J: 6 articles (07/2015 - 05/2005)
9.	Ferreira, Graziele C: 5 articles (10/2015 - 07/2011)
10.	Pluta, Ryszard M: 5 articles (01/2013 - 03/2005)

Related Diseases

1.	Poisoning 09/01/1955 - "[The study of poisoning with sodium nitrite. " 08/01/2014 - "We report a case of methaemoglobinaemia as a result of sodium nitrite poisoning." 08/01/2014 - "The book's title is based on Greenberg's investigation of accidental sodium nitrite poisoning among eleven elderly men in Manhattan who as a result, became cyanotic. " 10/01/2010 - "No cases exist, however, of intentional suicide by methaemoglobinaemia following self-poisoning with sodium nitrite. " 10/01/2010 - "Fatal methaemoglobinaemia induced by self-poisoning with sodium nitrite."
2.	Anoxia (Hypoxia) 11/28/2012 - "The marked changes in hepatic cells induced by sodium nitrite were completely abolished by pretreatment with the drug combination, suggesting potential protection against sodium nitrite-induced hypoxia. " 03/01/2015 - "Combined hypoxia and sodium nitrite pretreatment for cardiomyocyte protection in vitro." 02/01/2015 - "The anti‑hypoxic effects of CMN1 were determined using a sodium nitrite toxicosis test, acute cerebral ischemic/hypoxic test and normobarie hypoxia test. " 12/01/2014 - "rotundus possesses a protective effect against sodium nitrite-induced hypoxia in rats. " 12/01/2014 - "EECR at doses of 200 and 400 mg/kg was able to protect against the cognitive impairments, and the locomotor activity and muscular coordination defects, which are affected by sodium nitrite-induced hypoxia injury in rats. "
3.	Ischemia 02/15/2010 - "We investigated the role of eNOS in sodium nitrite (60 microM, 10 ml/kg applied topically 1 min before reperfusion)-induced protection against renal IRI in C57/BL6 wild-type (WT) and eNOS knockout (eNOS KO) mice subjected to bilateral renal ischemia (30 min) and reperfusion (24h). " 02/15/2010 - "In this study, we used genome expression profiling approaches to evaluate changes in gene expression in the hind-limb ischemia model using vehicle or sodium nitrite therapy. " 07/01/2015 - "Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome." 07/15/2012 - "The NO prodrug sodium nitrite significantly increases arteriogenesis and reperfusion of established severe chronic tissue ischemia." 07/15/2012 - "Here we examine the effect of administering the NO prodrug sodium nitrite on arteriogenesis activity during established tissue ischemia. "
4.	Amnesia (Dissociative Amnesia) 03/01/2010 - "In elevated plus maze and sodium nitrite-induced amnesia model, Celastrus paniculatus extract has showed statistically significant improvement in memory process when compared to control. " 03/01/2010 - "(Celastraceae) seed aqueous extract on learning and memory was studied using elevated plus maze and passive avoidance test (sodium nitrite induced amnesia rodent model). " 07/01/2005 - "To investigate the effect of bacosides (alcoholic extract of brahmi) on scopolamine (3 mg kg(-1), ip), sodium nitrite (75 mg kg(-1), ip) and BN52021 (15 mg kg(-1), ip) induced experimental amnesia in mice, using Morris water maze test, all the agents were administered 30 min before the acquisition trials on each day and repeated for 4 consecutive days, and on 5th day during the retrieval trials. " 10/01/2013 - "Scopolamine (I mg/kg, s.c.), sodium nitrite (25 mg/kg, i.p.), and electroconvulsive shock (150 mA, 0.2 sec) were used to induce amnesia. " 09/01/2000 - "transfer latency (TL) on elevated plus-maze, passive avoidance (PA), active avoidance (AA), scopolamine and sodium nitrite induced amnesia (SIA & NIA) in albino rats. "
5.	Reperfusion Injury 01/01/2013 - "The purpose of NITRITE-AMI is to test whether sodium nitrite reduces reperfusion injury and subsequent infarct size in patients undergoing PPCI for MI. " 01/01/2012 - "The hepatoprotective effect of sodium nitrite on cold ischemia-reperfusion injury." 05/27/2008 - "We have reported that sodium nitrite therapy exerts cytoprotective effects against acute ischemia/reperfusion injury in both heart and liver, consistent with the model of bioactive NO formation from nitrite during ischemic stress. " 04/01/2006 - "Effects of sodium nitrite on ischemia-reperfusion injury in the rat kidney." 11/01/2006 - "Early intravenous infusion of sodium nitrite protects brain against in vivo ischemia-reperfusion injury."

Related Drugs and Biologics

1.	Hydroxylamine (Hydroxylamine Hydrochloride)
2.	Citric Acid (Citrate)
3.	Carbon Monoxide
4.	Cod Liver Oil
5.	Nitric Oxide (Nitrogen Monoxide)
6.	Amyl Nitrite
7.	sodium thiosulfate
8.	Arginine (L-Arginine)
9.	Nitrites
10.	Liver Glycogen

Related Therapies and Procedures

1.	Resuscitation
2.	Oral Administration
3.	Injections
4.	Intraperitoneal Injections
5.	Intravenous Infusions