Sodium Glutamate (Accent)

One of the FLAVORING AGENTS used to impart a meat-like flavor. Medically it has been used to reduce blood ammonia levels in ammoniacal azotemia, therapy of hepatic coma, in psychosis, and mental retardation.

Also Known As:

Networked: 973 relevant articles (38 outcomes, 217 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sargent, Daniel J: 10 articles (12/2014 - 10/2007)
2.	Tsuneyama, Koichi: 9 articles (09/2014 - 02/2008)
3.	Beas-Zárate, C: 9 articles (08/2008 - 01/2001)
4.	Grassiolli, Sabrina: 8 articles (09/2015 - 04/2007)
5.	Yothers, Greg: 8 articles (12/2014 - 10/2007)
6.	Tamás, Andrea: 8 articles (04/2009 - 11/2004)
7.	Olson, Allan: 8 articles (12/2006 - 05/2002)
8.	Balbo, Sandra Lucinei: 7 articles (08/2015 - 04/2007)
9.	Bonfleur, Maria Lúcia: 7 articles (08/2015 - 04/2007)
10.	Taylor, Anne W: 7 articles (10/2014 - 08/2010)

Related Diseases

1.	Obesity 03/01/2004 - "MSG rats showed higher carcass fat as well as weight and cell size in epididymal adipose tissue than SAL rats, indicting the efficacy of the drug in producing obesity. " 01/01/2014 - "The efficacy of probiotics for monosodium glutamate-induced obesity: dietology concerns and opportunities for prevention." 10/01/2015 - "The present study was designed to test and compare the in vivo effects of 28-day consumption of a CBE-enriched diet (2%) on the antioxidant status of nonobese mice and mice with monosodium glutamate-induced obesity. " 02/01/2015 - "In this study, we examined the pathological changes in the liver in mice with obesity induced by monosodium glutamate administration. " 09/01/2014 - "However, some recent epidemiologic and animal studies have associated MSG use with obesity and aberrations in fat metabolism. "
2.	Insulin Resistance 07/01/2014 - "[Effect of Mudan Granule on islets beta cell function in monosodium glutamate induced obese mice with insulin resistance: an experimental study]." 11/01/2008 - "[A preliminary study on the mechanism of impaired beta cell function in monosodium glutamate obese rat with insulin resistance]." 09/20/1997 - "Partial characterization of insulin resistance in adipose tissue of monosodium glutamate-induced obese rats." 01/01/2013 - "This study reports that MSG did not trigger insulin resistance, dyslipidemia or hepatic steatosis, regardless of the diet, not reproducing the results of the above-mentioned study (Collison et al., 2010)." 06/01/2013 - "Swim training of 90-day-old MSG mice was used to evaluate whether signalling pathways of the IR and IRS-1 in islets are involved with the insulin resistance and glucose intolerance observed in this obese animal model. "
3.	Body Weight (Weight, Body) 09/01/1998 - "In hamsters raised in LD, the initial gain in body weight and testicular growth were significantly reduced by MSG treatment, however, growth rate and testis weight were still significantly greater than in vehicle- or MSG-treated hamsters raised in SD. " 09/01/2014 - "(3) Hypotheses positing dietary MSG effects on body weight involve results from rodent MSG injection studies that link MSG to actions in brain not applicable to MSG ingestion studies. " 10/10/2012 - "Previous studies suggest that MSG increases, decreases, or has no effect on the body weight of rodents. " 01/01/2011 - "In this study we assessed the effects of chronic (16 weeks) ad libitum MSG on body weight and metabolism of C57BL6/J mice. " 08/01/2010 - "In the present study, MSG intake and body weight were quantitatively assessed in 2002 and followed up in 2007. "
4.	Crohn Disease (Crohn's Disease) 12/01/2006 - "We further assessed this association in a subset of 344 patients from the large and well-defined cohort of 573 patients with Crohn's disease from the ACCENT I study. " 05/01/2005 - "Unemployment and disability rates in Crohn's disease patients from the ACCENT I trial were assessed. " 10/01/2002 - "SNPs were genotyped (TaqMan) in two cohorts ( n= 90 and n= 444 (ACCENT I)) of active Crohn's disease patients (CDAI 220-450). " 02/26/2004 - "Closing fistulas in Crohn's disease--should the accent be on maintenance or safety?" 07/01/2011 - "This analysis used serum infliximab concentration data from 692 patients (112 children, 580 adults; age range, 6-76 years) from 2 Phase III clinical studies (REACH [A Randomized, Multicenter, Open-Label Study to Evaluate the Safety and Efficacy of Anti-TNF-α Chimeric Monoclonal Antibody in Pediatric Subjects with Moderate-to-Severe Crohn's Disease] and ACCENT I [A Crohn's Disease Clinical Trial Evaluating Infliximab in a New, Long-term Treatment Regimen]). "
5.	Retinal Degeneration 03/09/2009 - "In summary, the present study showed that expanded field provided some degree of neuroprotection, while a complex environmental enrichment led to a manifest protection against retinal degeneration induced by neonatal MSG treatment in rats." 04/01/2009 - "The aim of the present study was to compare the effects of the physiologically occurring fragments PACAP1-38 and 1-27 and the widely used antagonists (PACAP6-38 and 6-27) in retinal degeneration induced by MSG in neonatal pups. " 09/01/2007 - "In the present study we investigated the effects of PACAP1-38 on a further signal transduction pathway possibly involved in the protective effect of intravitreal PACAP1-38 administration against apoptotic retinal degeneration induced by neonatal MSG treatment. " 03/01/2014 - "These findings support the neuroprotective function of Ucn 2 in MSG-induced retinal degeneration. " 01/10/2011 - "We have recently demonstrated that significant neuroprotection can be achieved in MSG-induced retinal degeneration in animals kept in an enriched environment. "

Related Drugs and Biologics

1.	Sodium Glutamate (Accent)
2.	Insulin (Novolin)
3.	infliximab (Remicade)
4.	Glucose (Dextrose)
5.	Non-alcoholic Fatty Liver Disease
6.	Glutamic Acid (Glutamate)
7.	Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)
8.	fibroblast growth factor 21
9.	Metformin (Glucophage)
10.	galactomannan

Related Therapies and Procedures

1.	Injections
2.	Oral Administration
3.	Subcutaneous Injections
4.	Vagotomy
5.	Splenectomy