Smallpox (Variola)

An acute, highly contagious, often fatal infectious disease caused by an orthopoxvirus characterized by a biphasic febrile course and distinctive progressive skin eruptions. Vaccination has succeeded in eradicating smallpox worldwide. (Dorland, 28th ed)
Also Known As:
Variola; Minor, Variola; Minors, Variola; Variola Minors; Variolas; Alastrim; Variola Minor
Networked: 1078 relevant articles (95 outcomes, 112 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Vaccinia
2. Infection
3. Smallpox (Variola)
4. Monkeypox
5. Measles


1. Poland, Gregory A: 21 articles (09/2014 - 10/2003)
2. Damon, Inger K: 19 articles (12/2015 - 06/2004)
3. Ovsyannikova, Inna G: 15 articles (09/2014 - 11/2008)
4. Frey, Sharon E: 14 articles (10/2015 - 10/2005)
5. Kennedy, Richard B: 13 articles (09/2014 - 05/2009)
6. Hruby, Dennis E: 12 articles (07/2015 - 10/2007)
7. Moss, Bernard: 12 articles (01/2011 - 08/2003)
8. Golding, Hana: 11 articles (03/2015 - 08/2003)
9. Edwards, Kathryn M: 11 articles (02/2015 - 02/2004)
10. Isaacs, Stuart N: 10 articles (01/2013 - 08/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Smallpox:
1. VaccinesIBA
12/30/2011 - "Significant changes that have taken place in the last thirty years, since the eradication of smallpox include, among others, (i) post-colonial political changes, with varying commitment to disease eradication initiatives, especially in the parts of the world most burdened by infectious and vaccine preventable diseases, (ii) innovations leading to the development of new and highly effective vaccines, targeted to specific diseases, (iii) the transformation brought about by improvement in education and the new global access to information (cell phones, internet, etc.), leading to an unlimited access to different types of information, subject to either positive or negative use. "
12/01/2009 - "Here, we review the history of smallpox vaccines and recent achievements in the development of highly efficacious and safer vaccines and vaccine applications. "
01/01/2015 - "The authors estimated that i) the likelihood of a smallpox outbreak in Denmark is very low (one event in 200,000 years), ii) the expected efficacy of currently available and new vaccines is 95 and 75 percent, respectively, iii) the expected frequency of serious side effects from vaccination is between 100 and 10,000 fold lower for new than for existing vaccines, depending on modes of action. "
01/01/2013 - "Vaccinia virus protein A33 (A33VACV) plays an important role in protection against orthopoxviruses, and hence is included in experimental multi-subunit smallpox vaccines. "
01/01/2004 - "These finding may have important implications both in our understanding of poxvirus pathogenesis and in the development of improved smallpox vaccines."
2. Smallpox VaccineFDA Link
3. AntigensIBA
4. cidofovir (Vistide)FDA Link
5. AntibodiesIBA
6. ST-246IBA
7. Proteins (Proteins, Gene)IBA
8. Complement System Proteins (Complement)IBA
9. DNA (Deoxyribonucleic Acid)IBA
10. Neutralizing AntibodiesIBA

Therapies and Procedures

1. Immunotherapy
2. Therapeutics
3. Drug Therapy (Chemotherapy)
4. Intradermal Injections
5. Occlusive Dressings (Occlusive Dressing)