Slow Virus Diseases

Diseases of viral origin, characterized by incubation periods of months to years, insidious onset of clinical manifestations, and protracted clinical course. Though the disease process is protracted, viral multiplication may not be unusually slow. Conventional viruses produce slow virus diseases such as SUBACUTE SCLEROSING PANENCEPHALITIS, progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL), and AIDS. Diseases produced by unconventional agents were originally considered part of this group. They are now called PRION DISEASES.

Also Known As:

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Amyloid Plaque
2.	Rubella (German Measles)
3.	Kuru

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Slow Virus Diseases:

1.	PrP 27-30 ProteinIBA 09/01/1986 - "Scrapie-associated fibrils (SAFs) are abnormal filamentous structures that are uniquely associated with unconventional slow virus diseases. " 01/01/1984 - "Proteins such as scrapie associated fibrils or prion in the brain of patients with "unconventional' slow virus diseases are related to the amyloid plaques. "
2.	Proteins (Proteins, Gene)FDA Link 01/01/1988 - "With immunochemical and biochemical methods we and others also showed that the protein constituting amyloid in AD/SDAT is different from amyloid in unconventional slow virus diseases." 01/01/1984 - "Proteins such as scrapie associated fibrils or prion in the brain of patients with "unconventional' slow virus diseases are related to the amyloid plaques. "
3.	PrionsIBA 12/01/1991 - "The mechanism of accumulation of prion amyloid in guinea pig CNS in experimental slow virus disease--amyotrophic leuco-spongiosis (AL) was studied. " 01/01/1984 - "Proteins such as scrapie associated fibrils or prion in the brain of patients with "unconventional' slow virus diseases are related to the amyloid plaques. "
4.	Amyloid (Amyloid Fibrils)IBA 12/01/1991 - "The mechanism of accumulation of prion amyloid in guinea pig CNS in experimental slow virus disease--amyotrophic leuco-spongiosis (AL) was studied. " 01/01/1988 - "With immunochemical and biochemical methods we and others also showed that the protein constituting amyloid in AD/SDAT is different from amyloid in unconventional slow virus diseases."
5.	PrPSc ProteinsIBA 05/06/1977 - "Latent form of Scrapie virus: a new factor in slow-virus disease."
6.	GangliosidesIBA 04/12/1974 - "Ganglioside changes in slow virus diseases: analyses of chimpanzee brains infected with kuru and Creutzfeldt-Jakob agents."
7.	AntigensIBA 09/01/1969 - "In this "slow-virus" disease the virus replicates rapidly and the morphologic and biochemical manifestations of disease are apparently due to the continuing interplay between a replicating antigen and the host immune response."
8.	Antigen-Antibody Complex (Immune Complex)IBA 06/01/1981 - "In two patients with the slow virus disease progressive rubella panencephalitis, high levels of immune complexes were found in serum and, in one case, spinal fluid. "

Therapies and Procedures

1.	Corneal Transplantation (Keratoplasty) 06/01/1975 - "A 49-year-old woman, following uncomplicated keratoplasty with donor material from a patient who had died of a slow virus disease, developed the same condition and died 18 months later. "