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Vesiculobullous Skin Diseases (Subcorneal Pustular Dermatosis)

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Skin diseases characterized by local or general distributions of blisters. They are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. (From Scientific American Medicine, 1990)

Also Known As:

Subcorneal Pustular Dermatosis; Skin Diseases, Vesiculobullous; Bullous Dermatoses; Vesiculobullous Dermatoses; Bullous Skin Disease; Dermatoses, Bullous; Dermatoses, Subcorneal Pustular; Dermatoses, Vesiculobullous; Dermatosis, Subcorneal Pustular; Pustular Dermatoses, Subcorneal; Skin Disease, Bullous; Skin Disease, Vesicular; Skin Disease, Vesiculobullous; Sneddon Wilkinson Disease; Subcorneal Pustular Dermatoses; Vesicular Skin Disease; Vesiculobullous Skin Disease; Bullous Skin Diseases; Pustular Dermatosis, Subcorneal; Skin Diseases, Bullous; Skin Diseases, Vesicular; Sneddon-Wilkinson Disease; Vesicular Skin Diseases

Networked: 295 relevant articles (12 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Skin and Connective Tissue Diseases
- Skin Diseases: 8226
  - Vesiculobullous Skin Diseases: 295

Related Diseases

1.	Vesiculobullous Skin Diseases (Subcorneal Pustular Dermatosis)
2.	Pemphigus (Pemphigus Vulgaris)
3.	Skin Diseases
4.	Bullous Pemphigoid (Pemphigoid)
5.	Pyoderma Gangrenosum

Experts

1.	Zillikens, Detlef: 12 articles (08/2015 - 02/2004)
2.	Hashimoto, Takashi: 10 articles (05/2013 - 04/2003)
3.	Hashimoto, T: 9 articles (01/2015 - 07/2000)
4.	Ishii, Norito: 7 articles (03/2015 - 07/2008)
5.	Hertl, M: 7 articles (09/2014 - 06/2000)
6.	Hertl, Michael: 6 articles (11/2011 - 01/2006)
7.	Ludwig, Ralf J: 4 articles (03/2015 - 04/2010)
8.	Borradori, Luca: 4 articles (10/2013 - 05/2008)
9.	Rose, Christian: 4 articles (06/2010 - 02/2004)
10.	Zillikens, D: 4 articles (05/2010 - 11/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Vesiculobullous Skin Diseases:

1.	AutoantibodiesIBA 12/01/1995 - "Recently, the use of human autoantibodies has helped to identify biologically important adhesion molecules of the skin, and the pathogenic mechanisms involved in bullous skin diseases are now being precisely defined." 04/01/2014 - "Detection of autoantibodies in autoimmune bullous skin diseases: can we do better?" 04/01/2014 - "Human amnion membrane (HAM) was suggested to be a superior antigenic substrate for immunoblotting in detecting autoantibodies of autoimmune bullous skin diseases. " 10/01/2011 - "Autoimmune bullous skin diseases are characterized by autoantibodies against adhesion molecules of the skin. " 05/01/2010 - "In this and other autoimmune bullous dermatoses, specific autoantibody detection systems are not only of diagnostic use but also allow monitoring of circulating and skin-bound autoantibodies during the course of the disease. "
2.	adalimumab (Humira)FDA Link 07/01/2010 - "Subcorneal pustular dermatosis treated successfully with adalimumab." 05/01/2013 - "Subcorneal pustular dermatosis, in addition to psoriasis vulgaris and pustular psoriasis, may occur in patients treated with TNF-α inhibitors like adalimumab." 05/01/2013 - "Palmoplantar subcorneal pustular dermatosis following adalimumab therapy for rheumatoid arthritis." 12/01/2013 - "[Sneddon-Wilkinson disease: efficacy of intermittent adalimumab therapy after lost response to infliximab and etanercept]." 09/01/2005 - "Rapid response of IgA pemphigus of the subcorneal pustular dermatosis subtype to treatment with adalimumab and mycophenolate mofetil."
3.	infliximab (Remicade)FDA Link 11/01/2005 - "Early but not lasting improvement of recalcitrant subcorneal pustular dermatosis (Sneddon-Wilkinson disease) after infliximab therapy: relationships with variations in cytokine levels in suction blister fluids." 03/01/2004 - "Infliximab has been used in the following dermatological diseases: psoriasis, Behcet's disease, graft versus host disease, hidradenitis suppurativa, panniculitis, pyoderma gangrenosum, SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome, sarcoidosis, subcorneal pustular dermatosis, Sweet's syndrome, toxic epidermal necrolysis, and Wegener's granulomatosis. " 12/01/2001 - "Infliximab (anti-tumor necrosis factor alpha antibody): a novel, highly effective treatment of recalcitrant subcorneal pustular dermatosis (Sneddon-Wilkinson disease)." 12/01/2013 - "[Sneddon-Wilkinson disease: efficacy of intermittent adalimumab therapy after lost response to infliximab and etanercept]."
4.	Intravenous Immunoglobulins (IVIG)FDA Link 03/01/2015 - "Although well-designed prospective trials are generally lacking, intravenous immunoglobulins (IVIG) seem an effective adjuvant treatment for autoimmune bullous skin diseases. " 04/01/2010 - "In the future, randomized controlled trials are necessary to better determine the efficacy and adverse effects of IVIG in the treatment of autoimmune bullous skin diseases. " 04/01/2010 - "We here summarize the clinical evidence supporting the notion, that IVIG is a promising therapeutic agent for the treatment of patients with autoimmune bullous skin disease. " 04/01/2010 - "A number of autoimmune bullous skin diseases have been identified in which IVIG treatment may be beneficial. " 01/01/2009 - "With the increasing use of IVIG for treatment of bullous dermatoses, recognition of this rare adverse effect is important for prompt differential diagnosis."
5.	Immunoglobulin A (IgA)IBA 08/01/1987 - "In a patient whose clinical features resembled subcorneal pustular dermatosis, IgA deposits in the intercellular space of the upper epidermis were found on direct immunofluorescence study. " 12/01/2001 - "To improve the method of immunoblotting for diagnosis of IgA-mediated bullous dermatoses. " 12/01/1999 - "Subcorneal pustular dermatosis and IgA lambda myeloma: a uncommon association but probably not coincidental." 01/01/1994 - "We report a 59-year-old woman who had subcorneal pustular dermatosis and IgA-kappa myeloma. " 01/01/1994 - "Subcorneal pustular dermatosis associated with IgA myeloma and intraepidermal IgA deposits."
6.	AntibodiesIBA 01/01/1992 - "Subepidermal autoimmune bullous dermatoses are defined by clinical, histological and immunological criteria, notably the presence of anti-basement membrane antibodies detectable in vivo by direct immunofluorescence. " 02/01/1968 - "Humoral antibodies in sera of patients with bullous skin diseases." 01/01/1967 - "[Anti-epidermal antibodies in bullous dermatoses. " 10/01/2012 - "Bullous pemphigoid (BP) is the most frequent autoimmune bullous skin disease, characterised by auto-antibodies against the hemidesmosome complex. " 07/01/1993 - "A paraneoplastic mixed bullous skin disease associated with anti-skin antibodies and a B-cell lymphoma."
7.	Dapsone FDA Link 01/01/1999 - "We report a case of subcorneal pustular dermatosis (SPD) first treated with dapsone with poor response. " 01/01/1995 - "A male patient with subcorneal pustular dermatosis was initially treated with dapsone with excellent response. " 05/01/2005 - "A relapse showing striking clinical characteristics of subcorneal pustular dermatosis was treated with dapsone (1 mg/kg/day) followed by ultraviolet B-narrowband (UV-B-NB) phototherapy. " 12/01/2004 - "A considerable number of other inflammatory as well as bullous dermatoses, of which dermatitis herpetiformis is the best known, have been shown to respond in varying degrees to dapsone, although the indication for the molecule has not been demonstrated in of them all. " 04/01/2009 - "Sneddon-Wilkinson disease (SWD), also known as subcorneal pustular dermatosis, is a rare, chronic eruption that is often difficult to treat, particularly in patients who do not respond to or cannot tolerate dapsone. "
8.	Collagen Type VIIIBA 09/01/2002 - "Dystrophic epidermolysis bullosa (DEB) is a bullous skin disease caused by mutations in the type VII collagen gene (COL7A1). " 09/01/2006 - "Epidermolysis bullosa acquisita (EBA) is a bullous skin disease caused by autoantibodies to type VII collagen. " 03/01/2015 - "Here, efficacy of IVIG monotherapy was compared with corticosteroid treatment in mice with immunization-induced experimental epidermolysis bullosa acquisita (EBA), an autoimmune bullous skin disease characterized by autoantibodies against type VII collagen. " 02/01/2013 - "We noted increased IL-6 levels in human and murine epidermolysis bullosa acquisita (EBA), a prototypic organ-specific autoimmune bullous dermatoses (AIBD) induced by autoantibodies to type VII collagen (COL7). "
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/01/2010 - "Autoimmune bullous skin diseases occurring under anti-tumor necrosis factor therapy: two case reports." 11/01/1991 - "Role of tumor necrosis factor-alpha in Sneddon-Wilkinson subcorneal pustular dermatosis. " 12/01/2001 - "Infliximab (anti-tumor necrosis factor alpha antibody): a novel, highly effective treatment of recalcitrant subcorneal pustular dermatosis (Sneddon-Wilkinson disease)."
10.	TNFR-Fc fusion protein (etanercept)FDA Link 04/01/2009 - "Sneddon-Wilkinson disease treated with etanercept: report of two cases." 09/01/2007 - "Successful treatment of long-standing, recalcitrant subcorneal pustular dermatosis with etanercept." 12/01/2013 - "[Sneddon-Wilkinson disease: efficacy of intermittent adalimumab therapy after lost response to infliximab and etanercept]."

Therapies and Procedures

1.	Phototherapy (Light Therapy) 07/01/1997 - "Subcorneal pustular dermatosis responsive to narrowband (TL-01) UVB phototherapy." 03/01/1986 - "Subcorneal pustular dermatosis treated with phototherapy." 07/01/1997 - "Subcorneal pustular dermatosis (Sneddon-Wilkinson disease) treated with narrowband (TL-01) UVB phototherapy." 05/01/2005 - "A relapse showing striking clinical characteristics of subcorneal pustular dermatosis was treated with dapsone (1 mg/kg/day) followed by ultraviolet B-narrowband (UV-B-NB) phototherapy. " 01/01/2009 - "Intralesional corticosteroid therapy for patients with Sweet syndrome and pyoderma gangrenosum, hyperbaric oxygen and plasmapheresis for patients with pyoderma grangrenosum, and phototherapy for patients with subcorneal pustular dermatosis are other modalities that have been used effectively for treating individuals with these neutrophilic dermatoses."
2.	Plasmapheresis 07/01/1980 - "[Plasmapheresis in the treatment of bullous skin diseases]." 07/01/1979 - "[Plasmapheresis in the treatment of bullous skin diseases]." 03/01/2006 - "In dermatology, specialized techniques like plasmapheresis and extracorporeal photochemotherapy have provided a good treatment option in immune-mediated disorders like bullous dermatoses, collagen vascular diseases and cutaneous lymphomas. " 01/01/2009 - "Intralesional corticosteroid therapy for patients with Sweet syndrome and pyoderma gangrenosum, hyperbaric oxygen and plasmapheresis for patients with pyoderma grangrenosum, and phototherapy for patients with subcorneal pustular dermatosis are other modalities that have been used effectively for treating individuals with these neutrophilic dermatoses."
3.	Lasers (Laser) 01/01/2002 - "Initially, both patients were misdiagnosed as subcorneal pustular dermatosis of Sneddon and Wilkinson and only subsequent careful immunofluorescence studies (in one case with confocal laser scanning microscopy) led to the correct diagnosis. " 12/01/2010 - "47 patients with different dermatoses such as benign and malign skin cancers, connective tissue diseases, inflammatory skin diseases, and autoimmune bullous skin diseases have been investigated with (i) state-of-the-art and highly sophisticated ultrasound systems for dermatology, (ii) the femtosecond laser multiphoton tomograph and (iii) dermoscopes. " 07/01/2009 - "47 patients with a variety of skin diseases and disorders such as skin cancer, psoriasis, hemangioma, connective tissue diseases, pigmented lesions, and autoimmune bullous skin diseases have been investigated with (i) state-of-the-art OCT systems for dermatology including multibeam swept source OCT, (ii) the femtosecond laser multiphoton tomograph, and (iii) dermoscopes. "
4.	Plasma Exchange 01/01/1986 - "[Corticoids and plasma exchange in autoimmune bullous dermatoses]." 11/01/1991 - "A patient with IgG-kappa-associated subcorneal pustular dermatosis (Sneddon-Wilkinson disease) refractory to dapsone, etretinate, and plasma exchange was successfully treated with corticosteroids. "
5.	Renal Dialysis (Hemodialysis) 09/25/1994 - "The authors review the knowledge on chronic hemodialysis-related PCT or the PCT-like bullous dermatoses: development of the above-mentioned conditions, clinical and morphological and biochemical features, difficulties in diagnosis, or the possibilities in therapy." 01/01/1987 - "Bullous dermatoses associated with hemodialysis are analyzed."