Silicosis

03/01/1993 - "The median (range) rate of clearance of 99mTc-DTPA in smokers with silicosis was 4.1 (1.9-12.7) %/minute, which was higher than the rates in non-smoking patients with silicosis of 2.2 (1.1-6.6) %/minute and in smokers without exposure to silica dust of 2.9 (1.6-4.5) %/minute. "
04/29/2005 - "Because no effective treatment for silicosis is available, effective control of exposure to crystalline silica in the workplace is crucial."
12/24/2015 - "In our study, mice were exposed to silica by intratracheal instillation, and in this way we established an experimental silicosis model. "
01/01/2015 - "This study aims to develop a prognostic risk prediction model for the development of silicosis among workers exposed to silica dust in China. "
10/01/2014 - "To study potential exposures to crystalline silica and the number of work-related cases of silicosis occurring in Alberta. "

09/01/1989 - "The genotoxicity of tetrandrine, a drug potentially useful for the treatment of silicosis, was studied using the micronucleus and the sister-chromatid exchange (SCE) assay systems. "
01/01/1988 - "The effects of tetrandrine, a benzylisoquinoline alkaloid useful in the treatment of silicosis, on a broad range of human neutrophil activities was examined in vitro. "
08/01/1986 - "Tetrandrine is a plant alkaloid useful in the treatment of silicosis. "
09/01/1995 - "A biochemical study on combined treatment of experimental silicosis with tetradrine-PVNO and tetradrine-QOHP in rats."
04/01/1983 - "[Preliminary study of the mechanism of silicosis therapy by tetrandrine]."

02/01/2014 - "The study concluded, the genetic variation on TNF-alpha gene locus -308 was a risk factor of silicosis in Indonesia cement factory. "
02/01/2014 - "The result showed proportion of the genetic variation on TNF-alpha on Locus -308 in Indonesia was significantly (p = 0.02) higher on silicosis (13.45%) than nonsilicosis (5.45%) but lower than silicosis in Africa and US miners, since susceptibility loci might vary in different ethnic groups. "
01/01/2013 - "Tumor necrosis factor-α (TNF-α) 308 G/A gene polymorphism has been reported to be associated with susceptibility to silicosis. "
01/01/2013 - "Association between tumor necrosis factor-α 308G/A gene polymorphism and silicosis susceptibility: a meta-analysis."
08/01/2011 - "Serum TNF-alpha in exposed group [(47.86 +/- 16.52) pg/ml], observing group [(109.11 +/- 31.08) pg/ml], silicosis group [(216.35 +/- 51.03) pg/ml] were significantly higher than that in control group [(6.90 +/- 2.24) pg/ml] (P < 0.01); Silicosis group and observing group were also higher than exposed group (P < 0.01, P < 0.05). "

10/01/2012 - "To observe the therapeutic efficacy of tetrandrine tablets combined with matrine injection in the treatment of silicosis. "
10/01/2012 - "[Therapeutic efficacy of tetrandrine tablets combined with matrine injection in treatment of silicosis]."
11/01/2013 - "To observe the clinical efficacy of tetrandrine combined with acetylcysteine effervescent tablets in the treatment of silicosis. "
11/01/2013 - "[Clinical efficacy of tetrandrine combined with acetylcysteine effervescent tablets in treatment of silicosis]."
11/01/2013 - "The combination of tetrandrine and acetylcysteine effervescent tablets show some effect in the treatment of silicosis. "

12/01/1991 - "We conclude that control of quartz exposure in the Vermont granite industry to levels which are on average less than the current OSHA standard has essentially eliminated definite radiographic changes of silicosis. "
01/01/2012 - "For this purpose, this study was planned to elicit the frequency of silicosis in quartz mill workers in Cine which is one of the largest quartz and feldspat areas, and to detect the working conditions, to inform the workers to improve the working conditions. "
01/01/2001 - "To study changes in liquid crystal structure of blood serum, the authors used intratracheal model of experimental silicosis in rats exposed to DQ12 quartz dust. "
05/01/1989 - "The purposes of this study were (1) to investigate the chronology of events in cellular and biochemical changes thought to be important in the development of silicosis, (2) to relate these to changes in lung function and radiograph, and (3) to evaluate the relation of quartz exposure and retention to individual response leading to early silicosis. "
01/01/1959 - "[Comparative animal experimental studies with quartz-containing ashes from acute and chronic pulmonary silicosis]."

01/01/2015 - "This study found, a) there was no significant decline in overall silicosis prevalence among working black miners in the South African gold mining industry between 1984 and 2004-2009, and b) a possible decline at one mine shaft more recently. "
12/01/2007 - "This study was to investigate the prevalence and risk factors of accelerated silicosis among Chinese gold miners. "
01/01/2003 - "The study included 73 gold miners with silicosis and 73 miners exposed to dusts but without silicosis. "
07/01/1993 - "In an earlier study of gold miners men with silicosis were found to have abnormal lung function, including airflow obstruction and reduced diffusing capacity. "
01/01/1970 - "The relationship between the amount of dust breathed and the development of radiological signs of silicosis: an epidermiological study in South African gold miners."

03/01/2014 - "Rifampicin plus INH (three months) vs. INH (six months) The 1992 silicosis trial did not detect a difference between people receiving rifampicin plus INH compared to INH alone for occurrence of active TB (one trial, 328 participants; very low quality evidence). "
03/01/2014 - "Rifampicin (three/four months) vs. INH (six months) Five trials published between 1992 to 2012 compared these regimens, and one small 1992 trial in adults with silicosis did not detect a difference in the occurrence of TB over five years of follow up (one trial, 312 participants; very low quality evidence). "
01/01/2013 - "Rifampicin plus INH (three months) vs. INH (six months)The 1992 silicosis trial did not detect a difference between people receiving rifampicin plus INH compared to INH alone for occurrence of active TB (one trial, 328 participants; very low quality evidence). "
01/01/2013 - "Rifampicin (three/four months) vs. INH (six months)Five trials published between 1992 to 2012 compared these regimens, and one small 1992 trial in adults with silicosis did not detect a difference in the occurrence of TB over five years of follow up (one trial, 312 participants; very low quality evidence). "
11/01/2012 - "Rifampicin monotherapy was shown to be effective in only one placebo-controlled trial in patients with silicosis, who have a very high risk of developing tuberculosis. "

01/01/2015 - "Plasma levels of TNF-α and MMP-9 are increased prior to development of clinically recognized silicosis, suggesting that these biomarkers are involved in the onset and development of silicosis. "
01/01/2015 - "We aimed at examining plasma levels of TNF-α and MMP-9, and correlation between these, in patients with different stages of silicosis in order to test suitability of these inflammatory factors as early biomarkers for silicosis. "
01/01/2015 - "Silicosis is usually recognized at later stages of the disease, and early biomarkers for silicosis will be useful for timely diagnosis. "
06/10/2014 - "Serum CA125 and NSE: biomarkers of disease severity in patients with silicosis."
05/01/2014 - "Association between inflammatory biomarkers in plasma, radiological severity, and duration of exposure in patients with silicosis."

07/01/2015 - "[Study on the therapeutic effects of tetrandrine combined with N-acetylcysteine on experimental silicosis of rats]."
03/01/2014 - "Here, we used N-acetylcysteine (NAC) to inhibit ROS activity to explore the effects of NAC on silica-induced pulmonary fibrosis in rats and provide evidence for study on the mechanism of silicosis. "
11/01/2013 - "To observe the clinical efficacy of tetrandrine combined with acetylcysteine effervescent tablets in the treatment of silicosis. "
11/01/2013 - "[Clinical efficacy of tetrandrine combined with acetylcysteine effervescent tablets in treatment of silicosis]."
11/01/2013 - "The combination of tetrandrine and acetylcysteine effervescent tablets show some effect in the treatment of silicosis. "

10/01/1996 - "These data suggest a major role for TGF-beta in silicosis, particularly in the formation of silicotic nodules and the development of PMF."
10/01/1996 - "In the nodular lesions of silicosis, central hyalinized areas contained the maximum staining for TGF-beta. "
10/01/1996 - "Transforming growth factor-beta (TGF-beta) in silicosis."
10/01/1996 - "We hypothesized that TGF-beta is associated with matrix deposition and fibrosis in silicosis. "
05/01/1996 - "Hepatic silicosis, cirrhosis, and liver tumors in mice and hamsters: studies of transforming growth factor beta expression."

09/01/1992 - "After successful animal studies since 1986, a single left lung transplantation was performed on a 35-year-old male patient with end-stage silicosis in July 1991. "
02/13/2015 - "No effective specific treatment for silicosis is available; patients are provided supportive care, and some patients may be considered for lung transplantation. "
11/01/2014 - "End-stage silicosis and lung transplantation: A way forward."
08/01/2012 - "We also compared the incidence of lung transplantation (LTX) due to silicosis in Israel with that of the International Society for Heart and Lung Transplantation (ISHLT) registry. "
08/01/2012 - "This retrospective cohort analysis included all patients with a diagnosis of silicosis who were referred for evaluation to the National Lung Transplantation Program in Israel from January 1997 through December 2010. "

07/01/2001 - "From among a total of 260 patients with silicosis contracted from granite work, 141 with available serial chest x ray films of acceptable quality taken over a period of 2 to 17 (mean 7.5) years, were selected for study. "
06/01/1996 - "In patients with stable shadows on chest X-ray films due to large opacities of silicosis, the delayed ratio was the same as or lower than the early ratio. "
02/06/1954 - "Comparison of different types of x-ray films for case finding and diagnosis of silicosis."
01/01/1985 - "A study was conducted to test the feasibility of training lay persons to screen chest x-ray films for professional readers in an industrial screening program and to use the International Labor Office classification of the pneumoconioses for silicosis. "
02/01/1992 - "We report an unusual case of acute silicosis in which improvement in clinical status, chest x-ray film findings and pulmonary function occurred following therapy with corticosteroids. "

12/01/2015 - "Long-term survival for adult patients with silicosis and non-silicotic OLD after LTx is not significantly different compared to the general lung transplant population."
08/01/2015 - "We systematically reviewed data from all cases of silicosis due to synthetic stone dust referred to our pulmonary institute for lung transplant assessment, which represents the national centre for all such referrals. "
01/26/2015 - "We present a 45-year-old male Danish sandblaster who developed silicosis, and due to rapid decline in lung function received a lung transplant with an excellent result."
08/01/2012 - "We systematically assessed an outbreak of silicosis among patients referred to our center for lung transplant. "
03/01/2012 - "During the first year post-transplant, those with OLD (silicosis and others combined) manifested an overall 2-fold increased mortality risk [hazard ratio (HR) 2.3, 95% CI 1.3-4.4; P < 0.05] compared to referents. "

12/01/1997 - "These results suggest that corticosteroid inhalation therapy is helpful in the management of chronic silicosis, especially in patients with sputum eosinophilia. "
12/01/1997 - "The efficacy of beclomethasone dipropionate (CAS 5534-09-8, BDP, beclomethasone) inhalation therapy over the course of 12 months were evaluated in 42 patients with established chronic silicosis. "
05/23/1965 - "[STUDY OF THE EFFECT OF TRYPSIN AEROSOL INHALATION THERAPY ON SILICOSIS]."

01/01/2014 - "Therefore, BMMC therapy in the late stages of experimental silicosis improved lung function by diminishing fibrosis but inflammatory cells persisted, which could be related to expansion of T regulatory cells, responsible for the beneficial effects of cell therapy."
01/01/1954 - "[Essay with tissue therapy in early silicosis; consecutive development of tuberculosis]."