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Sigma Factor

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A protein which is a subunit of RNA polymerase. It effects initiation of specific RNA chains from DNA.

Also Known As:

Minor Sigma Factor; RNA Polymerase Sigma Factor H; Factor, Sigma; Factor, Sigma Initiation; Initiation Factor, Sigma; Sigma Factor, Minor; Subunit, Sigma; Sigma Element; Sigma Initiation Factor; Sigma Subunit

Networked: 290 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Transcription Factors: 20597
    - Sigma Factor: 290

Experts

1.	Narberhaus, Franz: 5 articles (01/2013 - 02/2006)
2.	Tiburzi, Federica: 4 articles (06/2010 - 08/2005)
3.	Visca, Paolo: 4 articles (06/2010 - 08/2005)
4.	Hamood, Abdul N: 4 articles (10/2009 - 12/2007)
5.	Colmer-Hamood, Jane A: 4 articles (10/2009 - 12/2007)
6.	Völker, Uwe: 3 articles (04/2015 - 01/2012)
7.	Moreno, Soledad: 3 articles (03/2014 - 06/2011)
8.	Espín, Guadalupe: 3 articles (03/2014 - 06/2011)
9.	Imperi, Francesco: 3 articles (06/2010 - 08/2005)
10.	Thakur, Krishan Gopal: 3 articles (04/2010 - 08/2005)

Related Diseases

1.	Shock 03/01/2007 - "Recent studies with Myxococcus xanthus have suggested that homologues of the Escherichia coli heat-shock sigma factor, RpoH, may not be involved in the heat-shock response in this delta-proteobacterium. " 01/01/2013 - "Transcription of the ibpA gene depends on the alternative heat shock sigma factor σ(32). " 12/01/2012 - "Bacteria belonging to the Alphaproteobacteria normally harbour multiple copies of the heat shock sigma factor (known as σ(32), σ(H) or RpoH). " 06/01/2012 - "coli O157 crucial for growth resumption of this human pathogen after heat shock, with specific focus on the role of the RpoS sigma factor. " 01/01/2012 - "The model accurately reproduces changes of gene transcription level observed in polymerase sigma-subunit knockout and heat shock experiments in plant plastids. "
2.	Starvation 11/01/1996 - "The alternative sigma factor RpoS is a global regulator of gene expression during starvation and stress conditions and is required for virulence in Salmonella spp. We have used lacZ reporter fusions to rpoS and rpoS-dependent genes to study rpoS regulation after entry of Salmonella typhimurium into macrophages and epithelial cells. " 12/01/1992 - "In this study we evaluated the role of KatF, a putative sigma factor for starvation- and stationary phase-induced genes, in the expression of the spvB gene. " 12/01/2014 - "In many Gram-negative bacteria, starvation and other stress responses are regulated by the sigma factor RpoS. " 01/01/2012 - "Lactobacillus sakei, a non-sporulating meat-borne bacterium, carries an alternative sigma factor seemingly orthologous to σ(H) of Bacillus subtilis, best known for its contribution to the initiation of a large starvation response ultimately leading to sporulation. " 08/01/2010 - "Here we show that polyphosphate accumulated during nutrient starvation directly targets transcriptional machinery by binding to the principal sigma factor in H. "
3.	Contagious Ecthyma (Orf) 11/01/1999 - "In the present study, we provide evidence that the groESL, hrcA-grpE-dnaK and cbpA-hspR-orf operons encoding the major chaperones of the human gastric pathogen Helicobacter pylori are transcribed by the vegetative sigma factor sigma80 and are regulated negatively by the transcriptional repressor HspR. " 07/01/2008 - "The upstream region of the Tn5-mutated ORF contained another ORF that encoded an extra-cytoplasmic function (ECF)-class sigma factor (sigma(E), RpoE). " 07/01/2008 - "Cloning and sequencing of the Tn5 flanking region in both the carotenoid-producing mutants of Sp7 revealed insertion of Tn5 in an ORF encoding anti-sigma factor, a ChrR-like protein. " 12/01/2004 - "The suppressor consists of a transposon insertion in a previously annotated ORF, here termed hspQ, a novel heat shock gene whose promoter is recognized by the major heat shock sigma factor sigma32. " 10/01/1997 - "An ORF predicted to encode the primary sigma factor SigA was identified downstream of abcB."
4.	Infection 04/01/2015 - "Sigma Factor SigB Is Crucial to Mediate Staphylococcus aureus Adaptation during Chronic Infections." 02/01/2014 - "These results indicate that NonA is a novel protein that can abort SP10 infection, and its transcription was regulated by SP10 sigma factor. " 08/01/2013 - "RpoS, an alternative sigma factor, plays a central role in spirochetal adaptation to the mammalian host by governing expression of many genes important for mammalian infection. " 01/01/2012 - "We evaluated the contribution of the extracytoplasmic function sigma factor σ(E) for Corynebacterium pseudotuberculosis resistance to stress conditions resembling those found intracellularly during infection. " 01/01/2012 - "The alternative sigma factor B modulates virulence gene expression in a murine Staphylococcus aureus infection model but does not influence kidney gene expression pattern of the host."
5.	Tuberculosis (Tuberculoses) 01/01/2015 - "tuberculosis, 10 are regarded as the ECF sigma factor that exerts their attributes in various stress response. " 11/26/2013 - "tuberculosis protein, PDZ-interacting protease regulator 1 (Ppr1), which bridges between the Rip1 PDZ domain and anti-sigma factor M (Anti-SigM), a Rip1 substrate, but not Anti-SigK or Anti-SigL, also Rip1 substrates. " 08/01/2010 - "tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates." 04/16/2010 - "tuberculosis sigma factor sigma(L) regulates the expression of genes involved in cell-wall and polyketide syntheses. " 03/01/2009 - "tuberculosis employs an exquisite cascade consisting of the cognate anti-sigma factor UsfX and anti-anti sigma factors RsfA and RsfB to regulate the functions of the alternate sigma factor SigF. "

Related Drugs and Biologics

1.	DNA-Directed RNA Polymerases (RNA Polymerase)
2.	Proteins (Proteins, Gene)
3.	Iron
4.	Heat-Shock Proteins (Heat-Shock Protein)
5.	RNA polymerase sigma 70 (sigma 70)
6.	Carbon
7.	Nitrogen
8.	Staphylococcal Protein A (A, Protein)
9.	Secretory Immunoglobulin A (SIgA)
10.	alginic acid (sodium alginate)