Sialyltransferases

A group of enzymes with the general formula CMP-N-acetylneuraminate:acceptor N-acetylneuraminyl transferase. They catalyze the transfer of N-acetylneuraminic acid from CMP-N-acetylneuraminic acid to an acceptor, which is usually the terminal sugar residue of an oligosaccharide, a glycoprotein, or a glycolipid. EC 2.4.99.-.

Also Known As:

Networked: 88 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Peracaula, Rosa: 4 articles (08/2013 - 04/2010)
2.	Pérez-Garay, Marta: 3 articles (08/2013 - 02/2011)
3.	Rudd, Pauline M: 3 articles (01/2013 - 04/2010)
4.	Yuan, C C: 3 articles (01/2002 - 10/2001)
5.	Wang, P H: 3 articles (01/2002 - 10/2001)
6.	Ye, Xin-Shan: 2 articles (10/2015 - 01/2003)
7.	Gomes, Catarina: 2 articles (01/2015 - 01/2013)
8.	Reis, Celso A: 2 articles (01/2015 - 01/2013)
9.	Oliveira, Maria José: 2 articles (01/2015 - 01/2013)
10.	Malagolini, Nadia: 2 articles (09/2014 - 01/2009)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2016 - "Inhibitors of sialyltransferases thus are of medicinal interest, especially for the cancer therapy. " 09/01/2014 - "To propose a unifying model of the role of sialyltransferases and sialylated structures on cancer progression. " 09/01/2014 - "To describe the phenotypic and clinical implications of altered expression of sialyltransferases and of their cognate sialylated structures in cancer. " 09/01/2014 - "Sialosignaling: sialyltransferases as engines of self-fueling loops in cancer progression." 08/01/2013 - "Sialyltransferases have received much attention recently as they are frequently up-regulated in cancer cells. "
2.	Carcinoma (Carcinomatosis) 02/01/2015 - "Siaα 2-3Galβ1-3[Siaα2-6GalNAc]α-R and Siaα 2-6Gal/GalNAc sugar chains in hepatic carcinoma cell lines, HepG-2 and SMMC-7721 were upregulated, and 7differentially expressed sialyltransferases were captured. " 03/01/2000 - "In addition, fucosyltransferase FT-I (p<0.001) and sialyltransferases ST6Gal-I (p = 0.004) and ST3Gal-III (p = 0.001) showed increased expression in carcinoma specimens. " 12/18/1997 - "Glycolipid sialyltransferases are enhanced during neural differentiation of mouse embryonic carcinoma cells, P19." 01/01/1992 - "These findings support the general concept demonstrated in other carcinomas, that fucosyl- and sialyltransferases are preferentially activated in MTC.(ABSTRACT TRUNCATED AT 400 WORDS)" 08/01/1990 - "These findings reflect the impossibility of ET 18-0-CH3 to activate the sialyltransferases during the ganglioside biosynthesis in colon carcinoma cells, while it modified ceramide, glycerophospholipid and neutral glycerolipid biosynthesis."
3.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/01/2002 - "In this report we attempt to review the important findings in studing sialyltransferases of cervix squamous cell carcinoma." 01/01/2013 - "In this study, it was evaluated the expression of ST3Gal I and ST6Gal I in cutaneous epithelial lesions that include actinic keratosis (n=15), keratoacanthoma (n=9), squamous cell carcinoma (n=22) and basal cell carcinoma (n=28) in order to evaluate if sialyltransferases expression is different in premalignant and in malignant tumors. " 07/01/2002 - "Altered messenger ribonucleic acid (mRNA) expression of the four sialyltransferases (STs including ST3Gal I, ST3Gal III, ST3Gal IV, and ST6Gal I) is important in squamous cell carcinoma of the cervix. " 10/01/2001 - "This study of the changes in messenger ribonucleic acid (mRNA) expression of the four sialyltransferases (ST3Gal I, ST3Gal III, ST3Gal IV, and ST6Gal I) in a normal cervix and that with FIGO stage IB1 squamous cell carcinoma was undertaken to assess the extent of sialylation associated with establishment of the carcinoma. "
4.	Infection 06/01/1984 - "In this study, the modulation of the cellular ectosialyltransferase activity during viral infection was investigated. " 09/01/2014 - "Here, we investigated sialic acid linkage specificities for binding and infection of hPIV1 and hPIV3 by using sialic acid linkage-modified cells treated with sialidases or sialyltransferases. " 10/01/1980 - "Purified sialyltransferases (CMP-N-acetyl-neuraminate:D-galactosyl-glycoprotein N-acetylneuraminyl-transferase, EC 2.4.99.1) in conjunction with neuraminidase (acylneuraminyl hydrolase, EC 3.2.1.18) were used to produce cell surface sialyloligosaccharides of defined sequence to investigate their role in paramyxovirus infection of host cells. "
5.	Actinic Keratosis 01/01/2013 - "In this study, it was evaluated the expression of ST3Gal I and ST6Gal I in cutaneous epithelial lesions that include actinic keratosis (n=15), keratoacanthoma (n=9), squamous cell carcinoma (n=22) and basal cell carcinoma (n=28) in order to evaluate if sialyltransferases expression is different in premalignant and in malignant tumors. "

Related Drugs and Biologics

1.	beta-galactoside alpha-2,3-sialyltransferase
2.	beta-D-galactoside alpha 2-6-sialyltransferase
3.	Antigens
4.	5- acetylneuraminyl- (2- 3)- galactosyl- (1- 4)- (fucopyranosyl- (1- 3))- N- acetylglucosamine (sialyl Lewis x)
5.	Fucosyltransferases
6.	Messenger RNA (mRNA)
7.	RNA (Ribonucleic Acid)
8.	harpin (messenger)
9.	Epitopes
10.	5- acetylneuraminyl- 2- 3- galactosyl- 1- 3- (fucopyranosyl- 1- 4)- N- acetylglucosamine

Related Therapies and Procedures

1.	Investigational Therapies (Experimental Therapy)
2.	Immunotherapy