Necrotizing Sialometaplasia

A benign, inflammatory, variably ulcerated, occasionally bilateral, self-healing lesion of the minor salivary glands that is often confused clinically and histologically with carcinoma.

Also Known As:

Networked: 23 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Squamous Cell Carcinoma (Epidermoid Carcinoma)
2.	Mucoepidermoid Carcinoma
3.	Vomiting
4.	Polyps
5.	Pharyngitis (Sore Throat)

Experts

1.	Toner, M: 2 articles (08/2007 - 01/2004)
2.	Abdalla-Aslan, Ragda: 1 article (01/2020)
3.	Akrish, Sharon: 1 article (01/2020)
4.	Babichenko, I I: 1 article (01/2020)
5.	Freitas, Eliandro de Souza: 1 article (01/2020)
6.	Frid, Hanna: 1 article (01/2020)
7.	Ivina, A A: 1 article (01/2020)
8.	Leite, Milena Gomes Melo: 1 article (01/2020)
9.	Merhav, Goni: 1 article (01/2020)
10.	Pinheiro, Tiago Novaes: 1 article (01/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Necrotizing Sialometaplasia:

1.	Hematoxylin (Haematoxylon)IBA 05/01/2009 - "Interpreted in context collectively, these findings may be helpful adjuncts in the diagnosis of necrotizing sialometaplasia; nonetheless, to date, hematoxylin-eosin staining remains the gold standard." 02/01/2017 - "With hematoxylin and eosin and periodic acid-Schiff staining, intact epithelium, and submucosal glands remained after the RF procedures at the end of postoperative week 6. Following the KTP-laser intervention, necrotizing sialometaplasia and cartilage destruction occurred, and squamous metaplasia was also apparent in the Nd:YAG group. "
2.	Eosine Yellowish-(YS) (Eosin)IBA 05/01/2009 - "Interpreted in context collectively, these findings may be helpful adjuncts in the diagnosis of necrotizing sialometaplasia; nonetheless, to date, hematoxylin-eosin staining remains the gold standard." 02/01/2017 - "With hematoxylin and eosin and periodic acid-Schiff staining, intact epithelium, and submucosal glands remained after the RF procedures at the end of postoperative week 6. Following the KTP-laser intervention, necrotizing sialometaplasia and cartilage destruction occurred, and squamous metaplasia was also apparent in the Nd:YAG group. "
3.	Mutant Proteins (Protein, Mutant)IBA 01/01/2020 - "Due to the complexity of the differential diagnosis between necrotizing sialometaplasia and squamous cell carcinoma, an immunohistochemical method was used with antibodies to proteins Ki-67, P53, P63 and cytokeratins-7 and Immunohistochemical study established low proliferative activity of glandular cells in excretory ducts and metaplastic squamous epithelium for Ki-67 protein, significant expression of protein P63 was detected both in the ductal epithelium nuclei and in metaplastic areas and expression of the mutant protein P53 was approximately absent. "
4.	Proteins (Proteins, Gene)FDA Link 01/01/2020 - "Thus, the panel of antibodies to proteins Ki-67, P53 and cytokeratins-7 and 15 allows to verify necrotizing sialometaplasia. " 01/01/2020 - "Due to the complexity of the differential diagnosis between necrotizing sialometaplasia and squamous cell carcinoma, an immunohistochemical method was used with antibodies to proteins Ki-67, P53, P63 and cytokeratins-7 and Immunohistochemical study established low proliferative activity of glandular cells in excretory ducts and metaplastic squamous epithelium for Ki-67 protein, significant expression of protein P63 was detected both in the ductal epithelium nuclei and in metaplastic areas and expression of the mutant protein P53 was approximately absent. "
5.	AntibodiesIBA 01/01/2020 - "Thus, the panel of antibodies to proteins Ki-67, P53 and cytokeratins-7 and 15 allows to verify necrotizing sialometaplasia. " 01/01/2020 - "Due to the complexity of the differential diagnosis between necrotizing sialometaplasia and squamous cell carcinoma, an immunohistochemical method was used with antibodies to proteins Ki-67, P53, P63 and cytokeratins-7 and Immunohistochemical study established low proliferative activity of glandular cells in excretory ducts and metaplastic squamous epithelium for Ki-67 protein, significant expression of protein P63 was detected both in the ductal epithelium nuclei and in metaplastic areas and expression of the mutant protein P53 was approximately absent. "
6.	Local AnestheticsIBA 06/01/1996 - "The results of this study suggest that local anesthetic injections could be one of the causes of necrotizing sialometaplasia."
7.	Cocaine (Cocaine HCl)IBA 10/01/2013 - "Necrotizing sialometaplasia in an HIV positive cocaine user: a case report." 04/01/2008 - "A case of an ulcerated lesion in the palate of a cocaine-using patient whose diagnosis was necrotizing sialometaplasia is reported." 04/01/2008 - "Necrotizing sialometaplasia of the palate in a cocaine-using patient. "
8.	baysilon (polydimethylsiloxane)IBA 05/01/1995 - "Necrotizing Sialometaplasia after Silastic Ring Vertical Gastroplasty: Case Report and Review of Literature." 02/01/2016 - "Necrotizing sialometaplasia related to vomiting and silastic ring vertical gastroplasty."
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/01/2014 - "HIF-1α, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia."
10.	SteroidsIBA 01/24/2004 - "Necrotizing sialometaplasia: an unusual bilateral presentation associated with antecedent anaesthesia and lack of response to intralesional steroids. "

Therapies and Procedures

1.	Injections 06/01/1996 - "The results of this study suggest that local anesthetic injections could be one of the causes of necrotizing sialometaplasia."
2.	Gastroplasty (Vertical-Banded Gastroplasty) 05/01/1995 - "Necrotizing Sialometaplasia after Silastic Ring Vertical Gastroplasty: Case Report and Review of Literature." 02/01/2016 - "Necrotizing sialometaplasia related to vomiting and silastic ring vertical gastroplasty."
3.	Operative Surgical Procedures 12/01/2015 - "We also emphasize the fact that lesions like necrotizing sialometaplasia need a high degree of suspicion along with clinical co relation before subjecting the patient to unnecessary surgical procedures. " 05/01/2002 - "The surgical procedure is reported and discussed in detail, and the histopathological analysis showing a necrotizing sialometaplasia is reported. "
4.	Conservative Treatment 12/01/2015 - "Necrotizing sialometaplasia usually heals within 4 to 10 weeks with conservative treatment, and rarely recurs. " 11/01/2007 - "This paper reports a case of bilateral necrotizing sialometaplasia of the palate which resolved quickly with conservative treatment only. "
5.	Solid-State Lasers 02/01/2017 - "With hematoxylin and eosin and periodic acid-Schiff staining, intact epithelium, and submucosal glands remained after the RF procedures at the end of postoperative week 6. Following the KTP-laser intervention, necrotizing sialometaplasia and cartilage destruction occurred, and squamous metaplasia was also apparent in the Nd:YAG group. "