Necrotizing Sialometaplasia

A benign, inflammatory, variably ulcerated, occasionally bilateral, self-healing lesion of the minor salivary glands that is often confused clinically and histologically with carcinoma.

Also Known As:

Networked: 16 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Carcinoma (Carcinomatosis)
2.	Mucoepidermoid Carcinoma
3.	Neoplasms (Cancer)
4.	Necrosis
5.	Squamous Cell Carcinoma (Epidermoid Carcinoma)

Experts

1.	Toner, M: 2 articles (08/2007 - 01/2004)
2.	Halli, Rajshekhar: 1 article (09/2014)
3.	Koranne, Vaishali: 1 article (09/2014)
4.	Singh, Sarita: 1 article (09/2014)
5.	Joshi, Samir A: 1 article (09/2014)
6.	Hirshberg, A: 1 article (07/2014)
7.	Allon, D M: 1 article (07/2014)
8.	Allon, I: 1 article (07/2014)
9.	Vered, H: 1 article (07/2014)
10.	Shlomi, B: 1 article (07/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Necrotizing Sialometaplasia:

1.	Hematoxylin (Haematoxylon)IBA 05/01/2009 - "Interpreted in context collectively, these findings may be helpful adjuncts in the diagnosis of necrotizing sialometaplasia; nonetheless, to date, hematoxylin-eosin staining remains the gold standard."
2.	Eosine Yellowish-(YS) (Eosin)IBA 05/01/2009 - "Interpreted in context collectively, these findings may be helpful adjuncts in the diagnosis of necrotizing sialometaplasia; nonetheless, to date, hematoxylin-eosin staining remains the gold standard."
3.	tebufenozide (Mimic)IBA 01/01/2009 - "Clinically and histologically necrotizing sialometaplasia may mimic malignant lesions. " 01/01/2011 - "Histopathological examination is necessary for the diagnosis of necrotizing sialometaplasia because the clinical features of this condition can mimic other diseases, particularly malignant neoplasms." 09/01/1991 - "Necrotizing sialometaplasia is a benign inflammatory process, which histologically can mimic squamous cell carcinoma. " 08/01/1988 - "Necrotizing sialometaplasia is a benign disorder that histologically can mimic carcinoma. " 01/01/1984 - "Necrotizing sialometaplasia is said to mimic carcinoma, both clinically and histologically. "
4.	Cocaine (Cocaine HCl)IBA 10/01/2013 - "Necrotizing sialometaplasia in an HIV positive cocaine user: a case report." 04/01/2008 - "A case of an ulcerated lesion in the palate of a cocaine-using patient whose diagnosis was necrotizing sialometaplasia is reported." 04/01/2008 - "Necrotizing sialometaplasia of the palate in a cocaine-using patient. "
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/01/2014 - "HIF-1α, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia."
6.	SteroidsIBA 01/24/2004 - "Necrotizing sialometaplasia: an unusual bilateral presentation associated with antecedent anaesthesia and lack of response to intralesional steroids. "
7.	Keratins (Keratin)IBA 08/01/2007 - "To investigate the use of immunohistochemistry in distinguishing necrotizing sialometaplasia (NSM) from squamous cell (SCC) and mucoepidermoid carcinoma (MEC) by (i) the identification of myoepithelial cells and (ii) cytokeratin (CK) expression. " 08/01/2007 - "Necrotizing sialometaplasia versus invasive carcinoma of the head and neck: the use of myoepithelial markers and keratin subtypes as an adjunct to diagnosis."
8.	IceIBA 05/01/2014 - "Furthermore it describes the effects of extreme cooling of palatal mucosa with ice chips resulting in constriction of blood vessels as the direct cause, reinforcing ischemic etiology of necrotizing sialometaplasia."
9.	FibrinIBA 05/01/2009 - "Histological features of the specimens taken from turbinates 8 days after the surgery included necrosis and ulceration, fibrin deposition in the mucosa, necrotizing sialometaplasia, as well as proliferation of the granulation tissue. "
10.	tertiary SyphilisIBA 04/01/2008 - "Necrosis of the palate, meanwhile, is also the manifestation of other diseases such as tertiary syphilis, necrotizing sialometaplasia and malignant neoplasms. "

Therapies and Procedures

1.	Injections 06/01/1996 - "The results of this study suggest that local anesthetic injections could be one of the causes of necrotizing sialometaplasia."