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Showdomycin
3-beta-D-Ribofuranosylmaleimide. Antineoplastic antibiotic isolated from Streptomyces showdoensis. It is possibly active also as a sulfhydryl reagent.
Also Known As:
1H-Pyrrole-2,5-dione, 3-beta-D-ribofuranosyl-
Networked:
6
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Ribonucleosides: 49
Showdomycin: 6
2'-deoxyshowdomycin
3-(1,2-O-isopropylidene-threofuranos-4-yl)maleimide
3-(2,3-(isopropylidenedioxy)-4-(pivaloxymethyl)cyclopentyl)maleimide
3-(3-O-benzyl-1,2-O-isopropylidene-erythrofuranos-4-yl)maleimide
showdomycin 5'-phosphate
showdomycin diphosphate
showdomycin triphosphate
Related Diseases
1.
Leukemia L1210
11/30/1979 - "
Cytidine is twice as effective in reducing the toxicity of showdomycin for murine bone marrow cells in culture as it is for murine L1210 leukemia cella.
"
06/01/1981 - "
Cytotoxicities of cytosine arabinoside (Ara C) and showdomycin to murine L1210 leukemia cells was prevented by a nucleoside transport inhibitor, cimicifugoside.
"
2.
Neoplasms (Cancer)
05/01/1978 - "
The anti-tumor agent showdomycin is degraded in the presence of 0.05 M NH4HCO3 (pH 8.0) to a compound which carries a negatively charged group.
"
01/01/1972 - "
Transforming RNA excreted by showdomycin-resistant Escherichia coli induces a persistent, heritable, and spectacular change in Agrobacterium tumefaciens B(6), a bacterium that carries the oncogenic principle for tumor induction in plants.
"
3.
Lymphoma (Lymphomas)
05/01/1978 - "
Intracellularly, in mouse lymphoma cells (L5178y), showdomycin is phosphorylated to showdomycintriphosphate, via the mono- and diphosphate stage.
"
12/21/1981 - "
Cells of an adenosine-resistant clone (AE1) of S49 mouse lymphoma cells were compared with cells of the parental line with respect to (a) characteristics of nucleoside transport, (b) high affinity binding of the inhibitor of nucleoside transport, nitrobenzylthioinosine (NBMPR), and (c) the antiproliferative effects of the nucleoside antibiotics, tubercidin, arabinosyladenine and showdomycin.
"
4.
Brain Neoplasms (Brain Tumor)
04/01/1977 - "
[Clinical experience in the treatment of malignant brain tumors with small dose radiotherapy and showdomycin].
"
Related Drugs and Biologics
1.
Cytidine
2.
Nucleosides
3.
Vidarabine (Vira-A)
4.
Tubercidin
5.
RNA (Ribonucleic Acid)
6.
Diphosphates (Pyrophosphates)
7.
Cytarabine (Cytosar-U)
8.
Anti-Bacterial Agents (Antibiotics)
9.
Adenosine (Adenocard)
10.
cimicifugoside
Related Therapies and Procedures
1.
Radiotherapy