Hemorrhagic Shock

08/01/2013 - "There was significant improvement in hemodynamic parameters, oxygen delivery, and tissue perfusion of hemorrhagic-shock rats with 3 mg/kg of ICI 174,864 plus 1/4 volume of LR infusion. "
12/01/2006 - "In addition to its life-saving effect in hemorrhagic shock, transfusion of allogenic packed red blood cells can be beneficial in situations where a critically low hematocrit is contributing to a state of oxygen-supply dependency. "
01/01/2005 - "To investigate the protective effects of oxygen therapy on gut barrier function of rabbits after hemorrhagic shock at high altitude. "
12/01/1991 - "Inhibition of free radical-induced lipid peroxidation appears more effective for attenuating free radical pathophysiology in hemorrhagic shock that attempting to inhibit specific pathways of oxygen radical generation."
04/01/1994 - "To evaluate the efficacy of a novel, oxygen-transporting perfluorochemical emulsion as a prehospital therapy, using a canine hemorrhagic shock model based on compromised tissue oxygenation. "

01/01/1992 - "Modified hemoglobins are effective in hemorrhagic shock. "
08/01/2012 - "To investigate whether polymerized human placenta hemoglobin (PolyPHb) improved hemodynamic parameter recovery and cardiac function after hemorrhagic shock, a mean arterial pressure (MAP) of 30 mmHg was maintained for 60min. "
05/01/2010 - "Our study objectives were twofold: (1) to compare invasive and noninvasive measurements of local and systemic tissue hemoglobin oxygenation and (2) to compare the effects of various physiologic conditions seen in patients in hemorrhagic shock on tissue hemoglobin oxygenation. "
12/01/2006 - "The aim of the present study was to compare the hypoxic and inflammatory effects of transfusing hemoglobin-vesicles (HbV) or lactated Ringer's (LR) solution on several organs in a hemorrhagic shock model. "
10/01/2015 - "The patient presented a rapid increase in hemoglobin concentration and reticulocyte count with resolution of hemorrhagic shock after the proposed pharmacologic treatment combined with local hemostatic measures. "

01/01/2015 - "Hypertonic Saline Dextran Ameliorates Organ Damage in Beagle Hemorrhagic Shock."
10/01/2006 - "The objective of this study was to verify whether the association of dextran with 7.5% chloride solution would be advantageous in the immediate hemodynamic evaluation of controlled hemorrhagic shock in dogs. "
03/01/1999 - "The aim of the study was to investigate the effects of hypertonic saline dextran (HSD) on the early leukocyte/endothelial interactions (intravital fluorescence microscopy) in a rat model of hemorrhagic shock (1 hour at mean arterial pressure of 40 mm Hg). "
01/01/1989 - "The purpose of this study was to compare the benefit of small volume hypertonic saline/dextran (HSD) versus the risk of obligatory time to administer it on-scene in a model of acute hemorrhagic shock. "
12/01/1985 - "More studies are needed to document the safety of dextran in the clinical setting of hemorrhagic shock. "

01/01/2011 - "Hypertonic saline hydroxyethyl starch (HH) has been recommended for first line treatment of hemorrhagic shock. "
09/01/2006 - "To study the effect of hydroxyethyl starch (HES) on vascular reactivity of rat during hemorrhagic shock and its mechanism. "
01/01/2012 - "[Comparative effects of low and medium molecular hydroxyethyl starch (HES) solutions on hemorrhagic shock in rats]."
06/01/2011 - "Small volume 7.5% NaCl with 6% Dextran-70 or 6% and 10% hetastarch are associated with arrhythmias and death after 60 minutes of severe hemorrhagic shock in the rat in vivo."
05/01/2010 - "To observe the change in bone marrow after intraosseous hypertonic saline- hydroxyethyl starch (HSH) in dogs with hemorrhagic shock. "

02/01/1985 - "The beneficial effects of naloxone in hemorrhagic shock include increased blood flow to vital organs due to increased perfusion pressure which is secondary to improved cardiac performance."
11/01/1987 - "Two recent studies have demonstrated no improvement in hemodynamic parameters or survival following naloxone administration in hemorrhagic shock. "
09/01/1982 - "While the administration of naloxone to normal rats had no effect upon the circulation or cellular function, it improved the hemodynamic status of rats subjected to hemorrhagic shock, resulting in improved tissue perfusion. "
09/01/1980 - "Our results show that naloxone improved the hemodynamic and biochemical state of cats in hemorrhagic shock. "
06/01/1995 - "In order to study the clinical effects of naloxone on hemorrhagic shock, 21 patients with moderate hemorrhagic shock were randomly divided into two groups. "

12/01/1991 - "The efficacy of using colloids vs. crystalloids in the treatment of hemorrhagic shock remains controversial. "
01/01/2015 - "We evaluated the effects of various synthetic colloids and Lactated Ringer's (LR) solution on hemorheological parameters in vitro and in a rodent hemorrhagic shock model. "
03/01/2014 - "Plasma colloid osmotic pressure is an early indicator of injury and hemorrhagic shock."
04/01/2012 - "Artificial colloids, frequently used to prevent hemorrhagic shock in children, impair blood coagulation. "
01/01/2012 - "We examined the effects of medium-HES (mean molecular weight of 130,000 dalton) and low-HES (mean molecular weight of 70,000 dalton) on the survival rates (Exp. I), colloid osmotic pressure (COP) (Exp. II) and coagulation (Exp. III) with rats in hemorrhagic shock. "

05/15/2011 - "Melatonin ameliorates hemorrhagic shock-induced organ damage in rats."
01/01/2008 - "Melatonin treatment before hemorrhagic shock has been shown to improve liver function and hepatic perfusion. "
10/01/1996 - "While the mechanisms of the differential effects of melatonin administration are yet to be clearly defined, this study, nonetheless, demonstrates the salutary effects of short-term melatonin administration in the treatment of immune dysfunction following hemorrhagic shock."
08/01/2015 - "D-ß-hydroxybutyrate (BHB) and melatonin (M) treatment improves survival in animal models of hemorrhagic shock. "
08/01/2015 - "Safety of D-ß-Hydroxybutyrate and Melatonin for the Treatment of Hemorrhagic Shock With Polytrauma."

01/01/1983 - "In addition, RE function, which was markedly depressed following hemorrhagic shock, was significantly improved by ATP-MgCl2 treatment, indicating that the beneficial effect of ATP-MgCl2 for hemorrhagic shock could be through the improvement of RE function."
01/01/1983 - "The results indicate that survival was significantly improved if the animals were treated with ATP-MgCl2 following hemorrhagic shock. "
01/01/1983 - "There is controversy concerning the efficacy of ATP-MgCl2 in improving survival following hemorrhagic shock. "
01/01/1983 - "Improved survival and reticuloendothelial function with intravenous ATP-MgCl2 following hemorrhagic shock."
11/01/1985 - "The results of this study demonstrated that muscle ATP levels were sustained in hemorrhagic shock despite marked deterioration of muscle function as indicated by a decline in PD. "

10/01/2002 - "These beneficial findings indicate that pyruvate infused 30 min after the onset of severe hemorrhagic shock is effective in maintaining the redox environment, preventing the loss of the key antioxidant GSH, and decreasing early apoptosis indicators."
07/01/2015 - "Pyruvate dose response studies targeting the vital signs following hemorrhagic shock."
01/01/2013 - "During hemorrhagic shock the skeletal muscle response was characterized by a lack of increase in pyruvate and higher L:P ratios. "
07/01/2005 - "Pyruvate modulates hepatic mitochondrial functions and reduces apoptosis indicators during hemorrhagic shock in rats."
10/01/2002 - "Pyruvate improves redox status and decreases indicators of hepatic apoptosis during hemorrhagic shock in swine."

01/01/2011 - "The aim of this study was to compare, in a controlled volume-driven porcine model of hemorrhagic shock, the effects of three different crystalloid solutions on the hemodynamics and acid-base balance. "
01/01/2015 - "Preferential effects of low volume versus high volume replacement with crystalloid fluid in a hemorrhagic shock model in pigs."
09/01/2005 - "Those patients designated as being in hemorrhagic shock (defined as a systolic blood pressure less than 90 mmHg after receiving 2 L of intravenous crystalloid) were treated by application of the pelvic C-clamp. "
04/01/2004 - "Currently, submarine providers have only crystalloid available for the reversal of hemorrhagic shock. "
04/01/1997 - "Twelve piglets, mean weight 22 kg. The animals were anesthetized and bled to a state of hemorrhagic shock and resuscitated, using a crystalloid solution infused at a rate of approximately 2.6 mL/min/kg (total amount 208 mL/kg). "

04/01/1989 - "These results suggest that when PtCO2 is relied upon as an indicator of adequacy of resuscitation during moderate hemorrhagic shock, that cutaneous perfusion may be improved by the PASG or Trendelenburg position, and that perfusion is most effectively restored by blood infusion."
05/01/1996 - "The main therapeutic efforts, therefore, should be the effective treatment of traumatic hemorrhagic shock during the initial phase, adequate resuscitation, optimal oxygenation, and early surgical treatment."
08/01/2011 - "This study was designed to investigate myocardial protective effects and the mechanisms of high selective δ(1) and δ(2)-OR agonists during resuscitation of acute hemorrhagic shock. "
12/01/2013 - "Good outcomes have resulted from hypotensive resuscitation of hemorrhagic shock patients. "
02/01/2011 - "Small volume hypertonic saline resuscitation can be beneficial for treating hemorrhagic shock, but the mechanism remains poorly defined. "

03/01/1979 - "A theory is presented suggesting that the slowed rate of solute dispersion in the extracellular fluid (ECF) space during or after hemorrhagic shock is largely due to a depressed cardiac output, and that mixing may be improved by any fluid therapy that decreases the mean recirculation time for the solute. "
11/01/2012 - "This study suggests that, in hemorrhagic shock, treatment with low-dose VP, in combination with fluid therapy, improves tissue perfusion. "
11/01/2010 - "This study sought to define hemorrhagic shock from blood pressure and heart rate and then to provide a treatment policy based on response to initial fluid therapy. "
06/01/1977 - "[Experimental study of effects of fluid therapy on pulmonary changes in hemorrhagic shock (author's tranls)]."
02/13/2013 - "[Prehospital fluid therapy and stabilization in hemorrhagic shock]."

03/01/1976 - "Electrolyte solutions are effective in the immediate treatment of hemorrhagic shock, but the acceptable limits of hemodilution are not well defined. "
09/01/2007 - "Responsiveness to different volume therapies following hemodilution and hemorrhagic shock: a comparative experimental study in rats."
01/01/2013 - "Hemodilution was followed by a 55% by BV 40-minute hemorrhagic shock period, treated with transfusion of fresh or blood that was stored for 2 weeks. "
08/01/2012 - "Finally, the efficiencies of FLyP and plasma before lyophilization were compared on a hemorrhagic shock hemodilution model and tested on TEG(Haemoscope Corporation, Glenview, IL). "
11/01/2000 - "The effect of hemodilution on the splanchnic circulation during hemorrhagic shock (HS) is not well defined. "

04/01/2010 - "The purpose of this study was to describe a blinded intra-aortic balloon occlusion (IABO) procedure in pelvic fractures (PF) for patients with critically uncontrollable hemorrhagic shock (CUHS). "
01/01/1988 - "Further studies are needed to evaluate the effects of intermittent intraaortic balloon tamponade in hemorrhagic shock."
04/01/2015 - "Despite a growing call for use of resuscitative endovascular balloon occlusion of the aorta (REBOA) for critically uncontrolled hemorrhagic shock, there is limited evidence of treatment efficacy. "
10/01/2014 - "The inflammatory sequelae of aortic balloon occlusion in hemorrhagic shock."
02/01/2014 - "Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an adjunct than can be used to expand the window of salvage in patients with end-stage hemorrhagic shock. "

02/01/2010 - "Improved survival time with combined early blood transfusion and fluid administration in uncontrolled hemorrhagic shock in rats."
03/01/2012 - "Study 2: In rat studies using blood transfusion in acute hemorrhagic shock model, survival rate in Group C was significantly higher than those in Group D (P < 0.05). "
11/01/2004 - "This study confirmed that the NI-ASG quickly restored the vital signs of most women in severe hemorrhagic shock and stabilized them while awaiting blood transfusion."
07/01/2014 - "We are not against blood transfusions, just do not agree that the patient's own blood is discarded without making sure there will be enough blood in stock to get him out of the hemorrhagic shock. "
01/01/2014 - "It can lead to hemorrhagic shock required to massive blood transfusion. "