Pneumonic Pasteurellosis (Shipping Fever)

Bovine respiratory disease found in animals that have been shipped or exposed to CATTLE recently transported. The major agent responsible for the disease is MANNHEIMIA HAEMOLYTICA and less commonly, PASTEURELLA MULTOCIDA or HAEMOPHILUS SOMNUS. All three agents are normal inhabitants of the bovine nasal pharyngeal mucosa but not the LUNG. They are considered opportunistic pathogens following STRESS, PHYSIOLOGICAL and/or a viral infection. The resulting bacterial fibrinous BRONCHOPNEUMONIA is often fatal.

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Networked: 120 relevant articles (13 outcomes, 16 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Bovine Respiratory Disease Complex
2.	Pasteurella Infections (Pasteurellosis)
3.	Salmonella Infections (Salmonellosis)
4.	Extrinsic Allergic Alveolitis (Hypersensitivity Pneumonitis)
5.	Pleuropneumonia

Experts

1.	Shewen, Patricia E: 4 articles (10/2012 - 05/2003)
2.	Maheswaran, S K: 4 articles (06/2003 - 02/2001)
3.	Hobo, Seiji: 3 articles (04/2015 - 01/2008)
4.	Lo, Reggie Y C: 3 articles (10/2012 - 05/2003)
5.	Maheswaran, Samuel K: 3 articles (10/2007 - 12/2002)
6.	Highlander, S K: 3 articles (10/2001 - 07/2000)
7.	Hodgins, Douglas C: 2 articles (10/2012 - 06/2008)
8.	Dassanayake, Rohana P: 2 articles (05/2011 - 10/2007)
9.	Srikumaran, Subramaniam: 2 articles (05/2011 - 10/2007)
10.	Leite, F: 2 articles (06/2003 - 08/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pneumonic Pasteurellosis:

1.	VaccinesIBA 09/01/1996 - "The objective of this study was to evaluate the efficacy of three commercial vaccines against experimental pneumonic pasteurellosis in cattle. " 09/01/1996 - "Evaluation of efficacy of three commercial vaccines against experimental bovine pneumonic pasteurellosis." 04/01/1987 - "Vaccination-challenge experiments were conducted in colostrum-deprived calves to evaluate the efficacy of Pasteurella bacterins and vaccines against experimental pneumonic pasteurellosis. " 09/01/1996 - "The results from this study demonstrates that commercial vaccines evaluated in this trial did not confer optimal protection in vaccinated calves, against experimental pneumonic pasteurellosis. " 07/01/1989 - "By the 1980s some studies using live vaccines were reportedly successful in reducing the incidence of pneumonic pasteurellosis. "
2.	enrofloxacinIBA 06/01/1998 - "The clinical efficacy of enrofloxacin was tested in calves with experimentally induced pneumonic pasteurellosis. " 06/01/1998 - "The clinical efficacy of enrofloxacin in the treatment of experimental bovine pneumonic pasteurellosis." 08/20/1988 - "This field trial supports the in vitro studies which suggested than enrofloxacin is an appropriate therapy in cases of shipping fever." 08/20/1988 - "The effect of enrofloxacin therapy was investigated in 110 male double-muscled cattle weighing 275 +/- 3 kg, during a spontaneous outbreak of shipping fever occurring 11 +/- 2 days after they arrived in the feedlot. " 08/20/1988 - "Effect of enrofloxacin therapy on shipping fever pneumonia in feedlot cattle."
3.	Subunit VaccinesIBA 02/01/1996 - "The objective of this study was to evaluate the efficacy of three Pasteurella haemolytica A1 derived experimental subunit vaccines against pneumonic pasteurellosis in cattle. " 02/01/1996 - "Evaluation of three experimental subunit vaccines against pneumonic pasteurellosis in cattle."
4.	Theophylline (Theon)FDA LinkGeneric 09/01/1989 - "A field trial was conducted to determine the efficacy of theophylline in relieving respiratory distress associated with bovine respiratory disease complex (shipping fever). "
5.	Oxytetracycline (Terramycin)FDA Link 03/10/1990 - "The efficacy of long-acting oxytetracycline in the control of pneumonic pasteurellosis in lambs was tested on seven Scottish farms. " 07/31/1982 - "Effect of oxytetracycline therapy on experimentally induced pneumonic pasteurellosis in lambs." 11/01/1952 - "Terramycin and serum therapy for shipping fever." 09/01/1986 - "Infected, untreated calves consistently developed classic pneumonic pasteurellosis, infected calves treated with either oxytetracycline or sulfadimethoxine recovered from acute clinical disease, and the uninfected controls remained healthy. " 06/01/1986 - "Chloramphenicol, lincomycin and oxytetracycline disposition in calves with experimental pneumonic pasteurellosis."
6.	Bacterial VaccinesIBA 11/01/1980 - "A water-in-oil emulsion adjuvanted combination shipping fever bacterin containing Pasteurella multocida, P hemolytica, Salmonella typhimurium and certain other species was effective in field use as a prophylactic agent against shipping fever pasteurellosis and salmonellosis. " 07/01/1998 - "The serologic and protective responses to a streptomycin-dependent, modified-live vaccine and a killed (bacterin-toxoid) vaccine against experimental pneumonic pasteurellosis were compared. "
7.	danofloxacinIBA 06/02/2007 - "Efficacy of danofloxacin in the treatment of pneumonic pasteurellosis in specific pathogen-free lambs." 02/01/2005 - "When used to treat pneumonic pasteurellosis in calves, danofloxacin and enrofloxacin can be expected to deliver concentration-dependent bactericidal activity against M. "
8.	AerosolsIBA 01/01/1977 - "These findings suggest the occurrence of an immunologically mediated hypersensitivity pneumonitis in the lungs of vaccinates and point to the potential efficacy of live bacterial aerosols for stimulation of protective immunity in pneumonic pasteurellosis."
9.	tilmicosinIBA 07/01/1997 - "These data demonstrate that tilmicosin was effective in treating experimentally-induced pneumonic pasteurellosis as determined by alleviation of clinical signs, pathological findings at post mortem, and presence of viable bacteria from the lung. " 07/01/1997 - "Treatment of experimentally induced pneumonic pasteurellosis of young calves with tilmicosin."
10.	difloxacinIBA 06/01/2000 - "Results suggest that difloxacin and enrofloxacin were equally effective for treatment of calves with experimentally induced pneumonic pasteurellosis. "

Therapies and Procedures

1.	Catheters 05/01/1992 - "Use of an indwelling bronchial catheter model of bovine pneumonic pasteurellosis for evaluation of therapeutic efficacy of various compounds." 05/01/1992 - "A model of bovine pneumonic pasteurellosis, using an indwelling bronchial catheter for inoculation and subsequent lavage of a single main stem bronchus of the lung, was evaluated in a preliminary efficacy trial of an experimental therapeutic compound. "
2.	Endoscopes 12/01/1987 - "Antibiotic sensitivity of Pasteurella haemolytica isolated by means of a fibreoptic endoscope from cases of pneumonic pasteurellosis in cattle." 07/01/2003 - "zooepidemicus (S.z) the causative bacterial agent of equine shipping fever pneumonia (ESFP), as well as to investigate its pathogenesis, 10 horses (seven Thoroughbreds and three Anglo-Arab species, ranging from 2-4 years in age) were experimentally inoculated, via an endoscope, into bronchus of the lung lobe with a dose of 30 ml of 1-7 x 10(8) CFU/ml of S.z. " 12/01/1987 - "Bacterial isolations from tracheal and bronchial washes obtained with the aid of a fibreoptic endoscope were carried out over a 7 month period in a feedlot on calves suffering from acute pneumonic pasteurellosis. "
3.	Therapeutics 03/01/1950 - "Observations on the Therapeutics of Shipping Fever."