Sex Hormone-Binding Globulin

A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.

Also Known As:

Networked: 1172 relevant articles (14 outcomes, 139 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Stanczyk, Frank Z: 16 articles (10/2015 - 01/2003)
2.	Kaaks, Rudolf: 12 articles (04/2014 - 02/2003)
3.	Khaw, Kay-Tee: 12 articles (04/2014 - 11/2005)
4.	Boeing, Heiner: 11 articles (09/2014 - 05/2005)
5.	Rinaldi, Sabina: 11 articles (04/2014 - 02/2003)
6.	Hankinson, Susan E: 10 articles (10/2014 - 12/2004)
7.	Tumino, Rosario: 10 articles (04/2014 - 05/2005)
8.	Trichopoulos, Dimitrios: 10 articles (04/2014 - 04/2003)
9.	Riboli, Elio: 10 articles (04/2014 - 05/2005)
10.	Tworoger, Shelley S: 9 articles (10/2014 - 05/2003)

Related Diseases

1.	Insulin Resistance 01/01/2013 - "The aim of this study was to measure serum sex hormone binding globulin (SHBG) profile in Chinese peri-menopausal women, and assess its correlation with insulin resistance (IR)-related parameter, namely HOMA-IR, in this special population. " 01/01/2015 - "Mendelian randomization analyses indicate causal roles in PCOS aetiology for higher BMI (P=2.5 × 10(-9)), higher insulin resistance (P=6 × 10(-4)) and lower serum sex hormone binding globulin concentrations (P=5 × 10(-4)). " 12/01/2014 - "Sex hormone-binding globulin gene expression and insulin resistance." 03/01/2013 - "Sex hormone binding globulin and insulin resistance." 03/01/2013 - "Total and trunk fat percentages were negatively correlated with sex hormone binding globulin and were positively correlated with homeostatic model assessment of insulin resistance and free androgen index in the PCOS group.. "
2.	Weight Loss (Weight Reduction) 04/01/2002 - "Sex hormone-binding globulin levels and cardiovascular risk factors in morbidly obese subjects before and after weight reduction induced by diet or malabsorptive surgery." 12/01/1989 - "The significant rise in sex-hormone binding globulin was most probably associated with the weight reduction of 3.1 +/- 1.2 kg per week. " 12/01/2010 - "The aim of the present study was to investigate the effect of weight reduction in obese Caucasian children on insulin sensitivity, sex hormone-binding globulin (SHBG), DHEAS and the hypothalamo-pituitary-gonadal axis. " 01/01/2010 - "The present study examined the relationship between the metabolic risk profile (MRP) and total testosterone (TT) and free testosterone using the free androgen index (FAI) and sex hormone binding globulin (SHBG) in 36 Caucasian American (CA) and 30 African-American (AA) women volunteering for a weight loss study. " 01/01/2007 - "The aim of this study was to assess the impact of insulin sensitivity on the relationship between sex hormone-binding globulin (SHBG) and insulin levels during active weight loss in euthyroid obese women. "
3.	Hirsutism 07/01/1992 - "This study was designed to investigate the most important factors affecting serum concentrations of sex hormone-binding globulin (SHBG) in women with hirsutism. " 02/01/2012 - "When the cause of the raised FAI was investigated in both the groups of girls with hirsutism, the raised FAI in the obese girls was due to low serum sex hormone-binding globulin (SHBG) levels. " 01/01/2008 - "We investigated 252 non-obese female subjects aged 13-39 years to evaluate if an exaggerated descent of sex hormone binding globulin (SHBG) levels during adolescence can play a role in the development of hirsutism. " 01/01/2008 - "Sex hormone binding globulin decrease as a potential pathogenetic factor for hirsutism in adolescent girls." 02/01/2006 - "Hirsutism score, lipid, androgen, and sex hormone-binding globulin (SHBG) levels were evaluated at baseline. "
4.	Breast Neoplasms (Breast Cancer) 06/01/2015 - "Previous studies on the association between sex hormone binding globulin (SHBG) level and risk of breast cancer in postmenopausal women reported conflicting results. " 05/01/1992 - "Studies of MCF-7 breast cancer cells demonstrated that sex hormone-binding globulin (SHBG) is internalized by receptor-mediated endocytosis. " 06/01/2015 - "Sex hormone binding globulin and risk of breast cancer in postmenopausal women: a meta-analysis of prospective studies." 12/01/2008 - "Circulating levels of sex hormone-binding globulin (SHBG) are inversely associated with breast cancer risk in postmenopausal women. " 12/01/2008 - "Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women."
5.	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 05/01/2015 - "The objective of the present study was to evaluate the influence of TAAAA repeat allele length on the levels of serum sex hormone binding globulin (SHBG) and cardiovascular risk factors in patients with polycystic ovary syndrome (PCOS). " 10/01/2013 - "This study aims to evaluate the sex hormone binding globulin (SHBG) level as a predictor of response to pharmacological treatment in women with polycystic ovary syndrome (PCOS). " 08/01/2008 - "TAAAAn polymorphism in sex hormone-binding globulin (SHBG) gene has been found to influence the transcriptional activity of SHBG gene in vitro, and several studies have reported variable associations of this polymorphism with serum SHBG levels in women with polycystic ovary syndrome (PCOS). " 01/01/2016 - "Decreased sex hormone-binding globulin (SHBG) levels were associated with polycystic ovary syndrome (PCOS). " 01/01/2016 - "Common Variants in the Sex Hormone-Binding Globulin (SHBG) Gene Influence SHBG Levels in Women with Polycystic Ovary Syndrome."

Related Drugs and Biologics

1.	Testosterone (Sustanon)
2.	Hormones
3.	Insulin (Novolin)
4.	Androstenedione (4 Androstene 3,17 dione)
5.	Dehydroepiandrosterone Sulfate
6.	Androgens
7.	Glucose (Dextrose)
8.	Gonadotropins
9.	Estradiol (Estrace)
10.	Gonadal Steroid Hormones (Sex Hormones)

Related Therapies and Procedures

1.	Vegetarian Diet (Vegetarianism)
2.	Caloric Restriction
3.	Liver Transplantation
4.	Transplantation (Transplant Recipients)
5.	Orchiectomy (Orchidectomy)