Sertoli Cell Tumor

Gonadal neoplasm composed entirely of SERTOLI CELLS or may have a component of GRANULOSA CELLS. Some of the Sertoli cell tumors produce ESTROGEN or ANDROGENS, but seldom in sufficient quantity to cause clinical symptoms such as FEMINIZATION or masculinization (VIRILISM).

Also Known As:

Networked: 53 relevant articles (0 outcomes, 4 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Granulosa Cell Tumor
3.	Sex Cord-Gonadal Stromal Tumors (Sex Cord-Stromal Tumor)
4.	Sertoli-Leydig Cell Tumor
5.	Carcinoma (Carcinomatosis)

Experts

1.	Barner, Ross: 3 articles (03/2009 - 09/2007)
2.	Vang, Russell: 3 articles (03/2009 - 09/2007)
3.	Zhao, Chengquan: 3 articles (03/2009 - 09/2007)
4.	McManus, Kim: 2 articles (03/2009 - 10/2008)
5.	Dabbs, David: 2 articles (03/2009 - 10/2008)
6.	Vinh, Tuyethoa N: 2 articles (03/2009 - 10/2008)
7.	Young, Robert H: 2 articles (11/2008 - 10/2008)
8.	Ulbright, Thomas M: 2 articles (11/2008 - 02/2005)
9.	Ueda, Yoshimichi: 2 articles (03/2007 - 06/2005)
10.	Sato, Katsuaki: 2 articles (03/2007 - 06/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sertoli Cell Tumor:

1.	Inhibins (Inhibin)IBA 09/01/2004 - "Sertoli cell tumor of the testis (not otherwise specified) with the expression of neuroendocrine markers and without the expression of inhibin-alpha." 10/01/2008 - "The extent of expression of all 3 markers was similar in Sertoli cell tumor but greatest for WT1: 63%, 96%, and 78% of cases showed expression of SF-1, WT1, and inhibin, respectively, in more than 50% of tumor cells. " 10/01/2008 - "As an extension of our previous immunohistochemical studies of ovarian Sertoli cell tumor, expression of SF-1 and comparison with WT1 and inhibin were assessed in 111 primary ovarian tumors: 27 Sertoli cell tumors, 60 endometrioid tumors (including borderline tumors, conventional well-differentiated carcinomas, and sertoliform variants of carcinoma), and 24 carcinoids. " 09/01/2007 - "The diagnostic utility of WT1 in Sertoli cell tumor is similar to inhibin but better than that of calretinin." 09/01/2007 - "Coordinate patterns for the extent of expression of WT1, inhibin, and calretinin in pure Sertoli cell tumor showed that all 3 markers were positive in 54% of cases; however, 42% were positive for WT1 and inhibin but negative for calretinin. "
2.	Aromatase (CYP19)IBA 01/01/1997 - "We report an eight-year old boy who presented with gynecomastia and had Sertoli cell tumor of both testes with high aromatase activity. " 01/01/2016 - "In the present study, 25 sex cord-stromal tumors (20 granulosa cell tumors, 4 Sertoli-Leydig cell tumors, and a Sertoli cell tumor) were immunohistochemically examined for expression of P450 aromatase, which is critical for estrogenesis. " 05/01/2006 - "High TGFbeta1, estrogen receptor, and aromatase gene expression in a large cell calcifying sertoli cell tumor (LCCSCT): implications for the mechanism of oncogenesis." 01/01/2005 - "We report on a 7.25-year-old boy with PJS, bilateral gynecomastia, Sertoli cell tumor and nephrocalcinosis, and present the outcome of 1-year treatment with the aromatase inhibitor testolactone. " 01/01/2005 - "Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone."
3.	beta CateninIBA 11/01/2009 - "These studies show a causal link between overactive WNT/beta-catenin signaling and Sertoli cell tumor development and provide a novel mouse model for the study of Sertoli cell tumor biology." 11/01/2009 - "Overactive beta-catenin signaling causes testicular sertoli cell tumor development in the mouse." 12/01/2012 - "The presence of bilaterality as well as overexpression of beta-catenin by this tumor supports an association of the development of Sertoli cell tumor with the patient's FAP syndrome and adenomatous polyposis coli inactivation."
4.	MART-1 AntigenIBA 05/01/2007 - "The interstitial cell tumor, but not the Sertoli cell tumor, was immunohistochemically positive for Melan-A, consistent with steroid production. " 06/01/2005 - "The differences in immunostaining patterns for melan-A, CD10, and mitochondria as well as positivity for S-100 protein-beta might be useful diagnostic hallmarks of large cell calcifying Sertoli cell tumor for discrimination from Leydig cell tumor." 03/01/2009 - "Immunohistochemical stains for markers which have known variable specificity for sex cord-stromal lineage [inhibin, calretinin, MART-1/melan-A, CD99, steroidogenic factor 1 (SF-1, adrenal 4-binding protein), and WT1], were performed in 127 cases of 5 different types of ovarian sex cord-stromal tumors: adult granulosa cell tumor (n=32), Sertoli cell tumor (n=27), Sertoli-Leydig cell tumor (n=18), steroid cell tumor (n=25), and fibroma/fibrothecoma (n=25). " 02/15/2012 - "The tumor was positive for cytokeratin AE1/AE3, CAM 5.2, vimentin, CD56, CK8, synaptophysin and S100, and negative for inhibin, calretinin, WT1, CD99, CD117, CK5/6, CK7, chromogranin A, placental alkaline phosphatase, neuron specific enolase, D2-40, smooth muscle actin, Melan-A, epithelial membrane antigen and carbonic anhydrase IX. This is the second reported case of a Sertoli cell tumor with reactivity limited to neuroendocrine markers and the first such case of the sclerosing variant. "
5.	Testosterone (Sustanon)FDA Link 06/01/1995 - "On the other hand, medium collected from cultures of cells isolated from a Sertoli cell tumor was able to stimulate testosterone secretion in subcultures of control testicular cells in a way similar to that of hCG. " 11/01/2014 - "Postoperative pathological examination confirmed Sertoli cell tumor in 3 cases, adenomatoid tumor in another 3, and mature teratoma in the other 2. The patients were followed up for 6 months to 7 years (mean 4 years), which revealed no relapse and metastasis, nor significant differences from the baseline in the testosterone level, IIEF score, and routine semen parameters. " 10/01/1978 - "Nine ovarian Sertoli-Leydig tumors, showing varying degrees of differentiation, one pure ovarian Sertoli cell tumor, and one poorly differentiated stromal tumor of the testis, were examined for the presence of testosterone, estradiol and progesterone with an indirect immunoperoxidase method on formalin fixed paraffin embedded tissue. "
6.	Estrogens (Estrogen)FDA Link 11/01/1984 - "Estrogen-secreting Sertoli cell tumor of the ovary is rare. " 11/01/1984 - "Estrogen-producing Sertoli cell tumor of the ovary--a case report." 03/01/1981 - "Eight male dogs with Sertoli cell tumor had pancytopenia and bone marrow hypoplasia attributed to endogenous estrogen myelotoxicosis. " 05/01/2006 - "High TGFbeta1, estrogen receptor, and aromatase gene expression in a large cell calcifying sertoli cell tumor (LCCSCT): implications for the mechanism of oncogenesis."
7.	calretininIBA 09/01/2007 - "The diagnostic utility of WT1 in Sertoli cell tumor is similar to inhibin but better than that of calretinin." 09/01/2007 - "Coordinate patterns for the extent of expression of WT1, inhibin, and calretinin in pure Sertoli cell tumor showed that all 3 markers were positive in 54% of cases; however, 42% were positive for WT1 and inhibin but negative for calretinin. " 09/01/2007 - "Additionally, inhibin and calretinin immunostaining were performed in all cases of Sertoli cell tumor for purposes of comparing expression with WT1. " 03/01/2009 - "Immunohistochemical stains for markers which have known variable specificity for sex cord-stromal lineage [inhibin, calretinin, MART-1/melan-A, CD99, steroidogenic factor 1 (SF-1, adrenal 4-binding protein), and WT1], were performed in 127 cases of 5 different types of ovarian sex cord-stromal tumors: adult granulosa cell tumor (n=32), Sertoli cell tumor (n=27), Sertoli-Leydig cell tumor (n=18), steroid cell tumor (n=25), and fibroma/fibrothecoma (n=25). " 02/15/2012 - "The tumor was positive for cytokeratin AE1/AE3, CAM 5.2, vimentin, CD56, CK8, synaptophysin and S100, and negative for inhibin, calretinin, WT1, CD99, CD117, CK5/6, CK7, chromogranin A, placental alkaline phosphatase, neuron specific enolase, D2-40, smooth muscle actin, Melan-A, epithelial membrane antigen and carbonic anhydrase IX. This is the second reported case of a Sertoli cell tumor with reactivity limited to neuroendocrine markers and the first such case of the sclerosing variant. "
8.	ProgesteroneFDA LinkGeneric 09/01/1985 - "Progesterone secreting Sertoli cell tumor of the ovary." 10/01/1978 - "Nine ovarian Sertoli-Leydig tumors, showing varying degrees of differentiation, one pure ovarian Sertoli cell tumor, and one poorly differentiated stromal tumor of the testis, were examined for the presence of testosterone, estradiol and progesterone with an indirect immunoperoxidase method on formalin fixed paraffin embedded tissue. "
9.	S100 Proteins (S 100 Protein)IBA 03/01/2002 - "Utility of immunostaining for S-100 protein subunits in gonadal sex cord-stromal tumors, with emphasis on the large-cell calcifying Sertoli cell tumor of the testis." 06/01/2005 - "The differences in immunostaining patterns for melan-A, CD10, and mitochondria as well as positivity for S-100 protein-beta might be useful diagnostic hallmarks of large cell calcifying Sertoli cell tumor for discrimination from Leydig cell tumor."
10.	DNA (Deoxyribonucleic Acid)IBA 01/01/2012 - "Our case, to our knowledge, is the only other reported case of malignant large cell calcifying Sertoli cell tumor with clinical and histopathological features related to aggressiveness, such as large tumor size, cellular pleomorphism, high mitotic rate, necrosis and aneuploid deoxyribonucleic acid. " 06/01/1995 - "Our case and, to our knowledge, the only other reported case of malignant large cell calcifying Sertoli cell tumor had clinical and histopathological features related to aggressiveness, such as unusual patient age, large tumor size, cellular pleomorphism, high mitotic rate, necrosis and aneuploid deoxyribonucleic acid. "

Therapies and Procedures

1.	Orchiectomy (Orchidectomy) 10/01/2011 - "Orchiectomy was carried out and the pathological study informed a large cell calcifying Sertoli cell tumor (LCCSCT). " 01/01/2008 - "We report on a 20-year-old male who underwent a radical orchidectomy when he was 12 years old which revealed a Sertoli cell tumor in his right testis, and who presented with a 5 x 3 cm retroperitoneal metastatic mass 8 years after orchidectomy. " 01/01/2001 - "After undergoing the standard treatment, by means of groin radical orchiectomy, its pathologic analysis identified the lesion as Sertoli cell tumor conventional. " 01/01/1993 - "Radical orchiectomy was performed, and pathology revealed a Sertoli cell tumor. " 04/01/1979 - "An 8-mo-old boy had an orchiectomy for a Sertoli cell tumor. "
2.	Lymph Node Excision (Lymph Node Dissection) 08/01/2015 - "We present a patient with a lymphogenic metastasized Sertoli cell tumor, who 24 months after orchiectomy and extended retroperitoneal lymphadenectomy is relapse-free. "
3.	Ligation 09/01/2010 - "All patients underwent primary removal of the tumor; orchiectomy with high ligation of spermatic cord was performed in 7 and tumor enucleation in 4. At histology, 4 patients had Leydig cell tumors, 4 juvenile granulosa cell tumors, 1 Sertoli cell tumor, 1 incompletely differentiated SCST, and 1 SCST with an intermediate pattern Sertoli cell tumor/mixed form. "
4.	Drug Therapy (Chemotherapy) 08/01/2007 - "Surgical exploration revealed a metastatic pure Sertoli Cell tumor, which was treated with resection and chemotherapy. "