Self Mutilation

07/01/1996 - "2. Chronic treatment with the atypical neuroleptic risperidone at 4 mg daily has maintained a significant reduction in occurrence of self-mutilation."
05/01/1997 - "Remission of self-mutilation in a patient with borderline personality during risperidone therapy."
07/01/1996 - "Risperidone antagonism of self-mutilation in a Lesch-Nyhan patient."
05/01/2001 - "[The effect of risperidone on the self-mutilation of Lesch-Nyhan syndrome]."
02/01/1998 - "SCH-23390 eliminated L-dopa induced self-mutilation in all subjects, while risperidone eliminated self-mutilation in all but one subject."

02/01/1998 - "Upon maturation, animals were injected with L-dopa and placed in photocell cages for monitoring of locomotion, stereotypies, and self-mutilation. "
09/01/1984 - "Neonatal-6-OHDA treated rats given L-DOPA after a decarboxylase inhibitor showed a high incidence of self-mutilation behavior (SMB) and self-biting. "
02/01/1998 - "SCH-23390 eliminated L-dopa induced self-mutilation in all subjects, while risperidone eliminated self-mutilation in all but one subject."
01/10/1989 - "Clozapine also blocked the self mutilation resulting from L-dihydroxyphenylalanine (L-DOPA) administration to neonatal-6-OHDA-lesioned rats, an effect previously linked to D-1 receptor activation. "
11/01/1985 - "The present investigation supports the hypothesis that functionally supersensitive D-1 dopamine receptors are involved in the self-mutilation behavior (SMB) induced by L-dihydroxyphenylalanine (L-dopa) in rats treated neonatally with 6-hydroxydopamine (6-OHDA). "

05/01/2014 - "This review suggests that clozapine may be a beneficial treatment option for BPD especially in controlling symptom severity, psychotic symptoms, impulsivity, self-mutilation, number of days on enhanced observation, use of restraint, and overall functioning."
07/01/1999 - "After clozapine treatment, there were statistically significant reductions in incidents of self-mutilation (restraint), seclusion, the use of p.r.n. "
07/01/1999 - "These subjects had been admitted to 2 state psychiatric hospitals owing to severe self-mutilation and/or violence and subsequently treated with clozapine. "
07/01/1999 - "Clozapine reduces severe self-mutilation and aggression in psychotic patients with borderline personality disorder."
07/01/1999 - "These preliminary but nonetheless favorable results suggest that clozapine deserves careful consideration for a controlled study in patients with borderline personality disorder and psychoses, especially if the clinical issues include severe self-mutilation, aggression, and violence. "

11/01/1996 - "Two patients had increased self-mutilation when carbamazepine was stopped, then improved a second time when treatment was restarted. "
11/01/1996 - "Carbamazepine trial for Lesch-Nyhan self-mutilation."
11/01/1996 - "We performed nerve and muscle biopsies on four patients with Lesch-Nyhan syndrome and initiated an uncontrolled pilot trial to see if carbamazepine would reduce the self-mutilation in these patients. "

01/01/1992 - "These behaviors typically involved an oral component and included grooming and mouthing following SKF-38393 in depleted 10-day-old pups, mouthing following administration of either agonist to depleted weanlings, and probing and intense self-mutilation (forepaw and tongue biting) following the combined agonists in depleted weanlings. "
09/01/1999 - "At 94 days of age, animals were injected with either SKF-38393 (3.0 mg/kg, intraperitoneally (i.p.)), a dopamine D1 agonist, or m-chlorophenylpiperazine (m-CPP) (3.0 mg/kg, i.p.), a 5-HT2C agonist, in an attempt to evoke behaviors such as stereotypical chewing, head-nodding, self-biting and self-mutilation. "
02/01/1988 - "After systemic administration of SKF-38393 or L-dopa, central microinjection of the adenosine agonists, 2-chloroadenosine or 5'-N-ethylcarboxamide adenosine, were effective in preventing self mutilation induced by these dopamine agonists in neonatally lesioned rats. "
10/01/1989 - "Pretreatment with the 5-HT antagonist methysergide did not produce a change in apomorphine-induced locomotion and did not antagonize the self-mutilation or the other behaviors produced by L-DOPA or SKF-38393 in neonatally lesioned rats, suggesting that 5-HT hyperinnervation is not responsible for these drug-induced changes in neonatal 6-OHDA-lesioned rats."

11/01/1984 - "When neonatal 6-OHDA-treated rats were tested as adults, they exhibited marked stereotypies, self-biting and self-mutilation behavior (SMB) when given these dopamine agonists. "
01/01/1986 - "Dopamine agonist-induced stereotypic grooming and self-mutilation following striatal dopamine depletion."
02/01/1988 - "After systemic administration of SKF-38393 or L-dopa, central microinjection of the adenosine agonists, 2-chloroadenosine or 5'-N-ethylcarboxamide adenosine, were effective in preventing self mutilation induced by these dopamine agonists in neonatally lesioned rats. "

05/01/2008 - "We here report the case of a 30-year-old man with a confirmed diagnosis of LNS who was successfully treated for self-mutilation of his lips with repeated botulinum toxin A (BTX-A) injections in the facial perioral muscles. "
09/01/2005 - "This report describes a 10-year-old male child with confirmed LNS who was treated for self-mutilation of his hands, tongue, and lips with repeated botulinum toxin A (BTX-A) injections into the bilateral masseters. "
09/01/2005 - "Botulinum toxin as a novel treatment for self-mutilation in Lesch-Nyhan syndrome."
05/01/2008 - "Botulinum toxin: treatment of self-mutilation in patients with Lesch-Nyhan syndrome."

02/01/1998 - "SCH-23390 eliminated L-dopa induced self-mutilation in all subjects, while risperidone eliminated self-mutilation in all but one subject."
02/01/1990 - "SCH-12679 antagonized the self-mutilation behavior and behavioral responses induced by L-dihydroxyphenylalanine in neonatal-6-OHDA lesioned rats in a manner similar to the prototypic D1-dopamine antagonist SCH-23390 and, like SCH-23390, produced a deficit in avoidance responding in unlesioned rats. "

01/01/1986 - "A case of Lesch Nyhan syndrome with delayed onset of self-mutilation: search for abnormal biochemical, immunological and cell growth characteristic in fibroblasts and neurotransmitters in urine."

09/01/2000 - "An increased serotonergic action in the striatum may be crucial for the appearance of self-injurious behavior, and pharmacological evidence suggests the efficacy of serotonin agonists/antagonists for the treatment of the self-mutilation in LNS."

06/01/1990 - "Self-tattooing as an action of autoaggressive self-mutilation or self-destruction is not always necessarily psychotic in nature; it may also be found in patients in whom a depressive personality structure is accompanied by strong masochistic tendencies at a neurotic level. "
06/01/1990 - "Self-tattooing is a form of self-mutilation and may sometimes come close to an 'artefact'. "
06/01/1990 - "[Tattooing and self-mutilation of the skin in neurotic character disorder]."
05/01/1998 - "Self-mutilation (SM), the deliberate, nonsuicidal destruction of one's own body tissue, occurs in such culturally sanctioned practices as tattooing; body piercing; and healing, spiritual, and order-preserving rituals. "
02/01/2006 - "It also helped dermatologists to recognize patients with "borderline" states, which are particularly frequent in dermatology (ereutophobia, dysmorphophobia, tattooing, self-mutilation, artefacta dermatitis). "

12/01/2001 - "Improvement in severe self-mutilation following limbic leucotomy: a series of 5 consecutive cases."
12/01/2002 - "Limbic leucotomy in self-mutilation."
12/01/2001 - "In carefully selected patients as described in this report, limbic leucotomy may be an appropriate therapeutic consideration for self-mutilation associated with severe, intractable psychiatric disorders."
12/01/2001 - "We report the effects of limbic leucotomy in 5 consecutive patients with severe self-mutilation behaviors. "

02/01/2005 - "The aim of the study was to describe the development of self-mutilation after extensive dorsal rhizotomy of the brachial plexus performed during early ontogeny in rats. "
02/01/2005 - "1. Self-mutilation does not develop after the rhizotomy in the infant rats. "
02/01/2005 - "Self-mutilation in young rats after dorsal rhizotomy."
12/01/2004 - "Paradoxically, in animals presenting self-mutilation following rhizotomy the evaluated parameters were similar to those of controls. "
12/01/2004 - "After rhizotomy, rats were divided into two groups: rats without any signs of self-mutilation, and those presenting self-mutilation. "

06/06/1986 - "This study examined the role of descending brainstem inhibition on autotomy (self-mutilation) produced by neurectomy, and on the enhancement of autotomy by an injury prior to denervation. "
10/01/1999 - "Similarity between human self-mutilation and animal autotomy following denervation are discussed along with the different theories explaining the mechanism of this abnormal behaviour."
04/01/1998 - "Denervation of the hindpaw in rodents triggers autotomy, a behaviour of licking, scratching and self-mutilation of the denervated paw. "
09/01/1990 - "Spinal lesions alone (i.e., without denervation) in either ALC or DLF or combined DLF-ALC did not lead to any form of self-mutilation behavior. "
02/01/2001 - "In some rat strains, total hindpaw denervation triggers autotomy, a behavior of self mutilation presumably related to neuropathic pain. "

01/01/2003 - "Two strains, C57BL/6J and C57BL/10J, were found to be highly resistant to self-mutilation, and are thus ideal animal models for peripheral-nerve and whole-limb transplant studies."