Selenium

An element with the atomic symbol Se, atomic number 34, and atomic weight 78.96. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.

Networked: 5220 relevant articles (311 outcomes, 1210 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Schomburg, Lutz: 28 articles (11/2015 - 02/2008)
2.	Thompson, Ian M: 27 articles (06/2015 - 01/2003)
3.	Combs, Gerald F: 25 articles (10/2015 - 07/2002)
4.	Rayman, Margaret P: 23 articles (01/2016 - 11/2003)
5.	Diamond, Alan M: 23 articles (01/2015 - 06/2003)
6.	Klein, Eric A: 23 articles (01/2015 - 01/2003)
7.	Carlson, Bradley A: 22 articles (08/2015 - 12/2002)
8.	Morris, J Steven: 21 articles (03/2014 - 08/2002)
9.	Hatfield, Dolph L: 20 articles (08/2015 - 12/2002)
10.	El-Bayoumy, Karam: 20 articles (08/2014 - 11/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2006 - "Selenium levels showed marked decrease in the cancer group. " 11/01/1995 - "In order to ascertain that the efficacy of the high-selenium garlic in cancer protection is primarily dependent on the action of selenium we compared the effects of two batches of garlic powder with marked differences in their level of selenium enrichment, 112 or 1355 p.p.m. " 09/01/2011 - "Selenium may be beneficial in reducing the risk of cancer incidence and mortality in many cancer types such as liver, prostate, colorectal and lung. " 02/01/2011 - "Selenium treatment resulted in a significant reduction in blood volume and microvessel density of GEO tumors. " 11/01/1995 - "Efficacy of cancer prevention by high-selenium garlic is primarily dependent on the action of selenium."
2.	Prostatic Neoplasms (Prostate Cancer) 01/01/2004 - "In view of the fact that PSA is a well-accepted prognostic indicator of prostate cancer, an important implication of this study is that a selenium intervention strategy aimed at toning down the amplitude of androgen signaling could be helpful in controlling morbidity of this disease." 08/01/2011 - "Furthermore, selenium inhibits prostate cancer through multiple mechanisms, and it is beneficial in controlling the development of this disease. " 01/01/2010 - "The objective of this study is to investigate whether survivin gene silencing in conjunction with selenium treatment could enhance the therapeutic efficacy for prostate cancer and to elucidate the underlying mechanisms. " 02/01/2008 - "A previous prevention trial showed that selenium supplementation was effective in reducing (by 50%) the incidence of prostate cancer. " 01/01/2004 - "A previous controlled intervention trial showed that selenium supplementation was effective in reducing the incidence of prostate cancer. "
3.	Sepsis (Septicemia) 01/01/2003 - "Meta-analysis of the pooled data showed a significant reduction in the proportion of infants having one or more episodes of sepsis associated with selenium supplementation [summary RR 0.73 (0.57, 0.93); RD -0.10 (-0.17, -0.02); NNT 10 (5.9, 50)]. " 06/01/2013 - "Several randomized controlled trials have examined the efficacy of selenium supplementation on mortality in patients with sepsis. " 01/01/2001 - "Thus, selenium supplementation seems to improve the outcome of patients with SIRS, sepsis and severe injury, however, pivotal prospective clinical trials with sufficient statistical power are now necessary to finally prove the efficacy of a selenium supplementation in these diseases." 01/01/2014 - "The purpose of this study is investigating of Selenium effect on oxidative stress factors in animal model of sepsis. " 08/01/2013 - "Selenium supplementation for sepsis: a meta-analysis of randomized controlled trials."
4.	Infection 11/01/2002 - "A marked decrease in total admission rates (RR = 0.38; p =.002) and percent of hospitalizations due to infection/100 patients for those receiving selenium was observed (p =.01). " 08/01/2010 - "Supplementation with selenium provided greater antioxidant protection against oxidative stress generated from experimental infection of lambs with H. " 03/01/2013 - "In this randomized double-blind placebo-controlled trial, 80 patients on stable HD for at least 3 months without any acute illness or active infections were randomly allocated to two equal groups to receive one selenium (200 µg) or placebo capsule daily for 12 weeks. " 01/01/2009 - " selenium trials reported no inflammatory episodes during the trial period in the treated group but one case of infection in the two placebo groups respectively. " 01/01/2008 - "Our results may serve as a basis for further studies of the biological function of selenium and control of PCV2 infection."
5.	Body Weight (Weight, Body) 06/01/2015 - "An optimum response with supplementation of selenium in diet has been found to improve feed intake, body weight gain, feed efficiency, egg production and quality, and antioxidant status in heat-stressed poultry. " 04/01/2013 - "At dosage levels in the nutritional range such as 1 μg Se/kg body weight, selenium ameliorates the atherogenic index and preserves the antioxidant capacity of the erythrocytes." 01/01/1976 - "Selenium supplementation improved body weights over controls while lead additions caused reduced egg production and ALAD activity. " 07/01/1996 - "Body weights of ducks receiving 40 or 80 ppm selenium declined during the study. " 11/01/1993 - "They were maintained on a selenium-deficient diet, and on day 0 of the study the treatment group was given 0.05 mg Se/kg body weight intramuscularly, while the control group received a placebo. "

Related Drugs and Biologics

1.	Vitamin E
2.	Zinc
3.	Vitamins
4.	Micronutrients
5.	beta Carotene (Betacarotene)
6.	Glutathione Peroxidase
7.	Sodium Selenite (Selenite)
8.	Antioxidants
9.	Ascorbic Acid (Vitamin C)
10.	alpha-Tocopherol

Related Therapies and Procedures

1.	Chemoprevention
2.	Radiotherapy
3.	Injections
4.	Drug Therapy (Chemotherapy)
5.	Heterologous Transplantation (Xenotransplantation)