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Secretin

A peptide hormone of about 27 amino acids from the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level. (USAN and the USP Dictionary of Drug Names, 1994, p597)

Also Known As:

Secrepan; Secretin Citrate, Pig; Secretin Maleate, Pig; Secretin Pentacetate, Pig; Secretin Sulfate, Pig; Secretin, Pig; Secretin-KABI; Pig Secretin; Pig Secretin Citrate; Pig Secretin Maleate; Pig Secretin Pentacetate; Pig Secretin Sulfate; Secretin KABI; SecretinKABI

Networked: 1332 relevant articles (63 outcomes, 150 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Alpini, Gianfranco: 10 articles (11/2014 - 04/2003)
2.	Francis, Heather: 10 articles (11/2014 - 04/2003)
3.	Glaser, Shannon: 10 articles (11/2014 - 04/2003)
4.	Stevens, Tyler: 10 articles (04/2012 - 02/2006)
5.	Conwell, Darwin L: 9 articles (03/2013 - 01/2003)
6.	Goggins, Michael: 8 articles (05/2015 - 01/2003)
7.	Zuccaro, Gregory: 8 articles (09/2010 - 01/2003)
8.	Hruban, Ralph H: 7 articles (05/2015 - 01/2003)
9.	Vargo, John J: 7 articles (11/2011 - 01/2003)
10.	Miller, Laurence J: 7 articles (08/2009 - 02/2002)

Related Diseases

1.	Autistic Disorder (Autism) 12/09/1999 - "A single dose of synthetic human secretin is not an effective treatment for autism or pervasive developmental disorder." 07/01/2002 - "A number of controlled clinical trials did not show improvement in autistic symptoms with secretin compared with placebo, possibly indicating no role for the drug in autistic disorder." 06/01/2002 - "To determine the efficacy of secretin, we completed a double-blind, placebo-controlled, crossover (3 weeks) study in children with autism/PDD and various GI conditions using a single dose of intravenous porcine secretin. " 02/01/2002 - "Further studies should be conducted to determine the safety and efficacy of secretin for autism." 01/01/2012 - "Meta-analysis of data was not possible but there is now consistency of findings, with RCTs of the efficacy of secretin in autism not showing improvements for core features of ASD. "
2.	Pancreatitis 05/01/2011 - "In the subgroup analysis, secretin was highly protective against post-ERCP pancreatitis for patients undergoing biliary sphincterotomy (6/129 vs 32/142, P < 0.001), patients undergoing cannulation of the common bile duct (26/339 vs 56/342, P < 0.001), and patients not undergoing pancreatic sphincterotomy (26/388 vs 57/403, P = 0.001). " 05/01/2012 - "Despite several promising reports of pharmacologic agents that have demonstrated the efficacy for prophylaxis against post-ERCP pancreatitis such as nonsteroidal anti-inflammatory drugs and secretin, there are currently no universally accepted agents for use in high-risk patients. " 05/01/2011 - "This study aimed to evaluate whether synthetic secretin is effective in reducing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. " 05/01/2012 - "Secretin during ESWL appears to aid clearance of MPDS in chronic calcific pancreatitis. " 01/01/2007 - "Secretin-stimulated DW-MRI may help to detect mild or early pancreatitis."
3.	Chronic Pancreatitis 01/01/2004 - "The gold standard used for the diagnosis of chronic pancreatitis was the final result of the complete 60-minute secretin stimulation test. " 04/01/2000 - "Even in chronic pancreatitis a significant improvement of imaging quality could be observed, but only in patients without duct dilation before secretin. " 12/01/2008 - "The purpose of this study was to determine the improvement in sensitivity and specificity of magnetic resonance cholangiopancreaticography (MRCP) in the diagnosis of chronic pancreatitis due to the application of secretin. " 01/01/1985 - "Modern diagnostic tests such as sonography, CT, ERCP and the secretin-CCK test do not provide a "gold standard" for early chronic pancreatitis. " 10/01/2009 - "The aim of this study was to compare radial and linear EUS for the diagnosis of chronic pancreatitis using the secretin-stimulated endoscopic pancreatic function test (ePFT) as the reference standard. "
4.	Exocrine Pancreatic Insufficiency 01/01/2007 - "The secretin-induced pancreatic T2 signal intensity changes are significantly reduced in patients with a mild exocrine pancreatic insufficiency as compared with healthy volunteers. " 10/01/2006 - "Data on magnetic resonance cholangiopancreatography with secretin stimulation (S-MRCP) for the assessment of exocrine pancreatic insufficiency (EPI) are limited. " 10/01/2006 - "Does secretin-stimulated MRCP predict exocrine pancreatic insufficiency?: A comparison with noninvasive exocrine pancreatic function tests." 03/01/2005 - "The duodenal mucosa in chronic pancreas patients with pancreatic insufficiency has a normal concentration of s-cells and, therefore, the production of secretin is preserved. " 10/01/2000 - "The accuracy of synthetic porcine secretin in diagnosing pancreatic insufficiency was 100% when compared with biologic porcine secretin. "
5.	Gastrinoma 09/01/1981 - "We conclude that the secretin provocation test is helpful in the diagnosis of gastrinoma." 03/01/2014 - "Synthetic human secretin is used for studies of exocrine pancreatic secretion, secretin-enhanced magnetic resonance cholangiopancreatography combined with exocrine pancreatic function test and diagnosis of gastrinoma syndrome. " 11/01/2006 - "These results indicate that combining selective arterial secretin injection test with conventional imaging studies contributes to increasing rate of curative resection of gastrinoma." 01/01/1986 - "Decision and cost-effectiveness analyses were employed in the present study to compare and contrast the diagnostic strategies of initial gastric analysis followed by secretin infusion test versus secretin infusion test alone in the evaluation of hypergastrinemia in patients suspected of having gastrinoma. " 09/01/2009 - "Magnetic resonance imaging demonstrated a pituitary macroadenoma, and gastrinomas were confirmed by computed tomography and a secretin stimulation test. "

Related Drugs and Biologics

1.	Caerulein (Ceruletide)
2.	Gastrins
3.	Cholecystokinin (Pancreozymin)
4.	Pancreatic Elastase (Elastase)
5.	Chymotrypsin
6.	Somatostatin (Somatotropin Release-Inhibiting Factor)
7.	Hormones
8.	Glucagon (Glukagon)
9.	Calcium
10.	Trypsin

Related Therapies and Procedures

1.	Injections
2.	Ligation
3.	Catheters
4.	Oral Administration
5.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)