Seborrheic Dermatitis

A chronic inflammatory disease of the skin with unknown etiology. It is characterized by moderate ERYTHEMA, dry, moist, or greasy (SEBACEOUS GLAND) scaling and yellow crusted patches on various areas, especially the scalp, that exfoliate as dandruff. Seborrheic dermatitis is common in children and adolescents with HIV INFECTIONS.

Also Known As:

Networked: 453 relevant articles (78 outcomes, 70 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Acne Vulgaris
2.	Hirsutism
3.	Atopic Dermatitis (Atopic Eczema)
4.	Psoriasis (Pustulosis Palmaris et Plantaris)
5.	Skin Diseases

Experts

1.	Gupta, Aditya K: 6 articles (10/2007 - 07/2003)
2.	Lee, Yang Won: 5 articles (12/2014 - 03/2009)
3.	Gupta, A K: 4 articles (01/2014 - 01/2002)
4.	Rezaee, Elham: 4 articles (01/2013 - 01/2013)
5.	Goldust, Mohamad: 4 articles (01/2013 - 01/2013)
6.	Zouboulis, Christos C: 4 articles (05/2009 - 01/2004)
7.	Choe, Yong Beom: 3 articles (12/2014 - 03/2009)
8.	Ahn, Kyu Joong: 3 articles (12/2014 - 03/2009)
9.	Warshaw, Erin M: 3 articles (09/2014 - 08/2007)
10.	Raghifar, Ramin: 3 articles (01/2013 - 01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Seborrheic Dermatitis:

1.	ciclopirox (Loprox)FDA LinkGeneric 01/01/2003 - "In a placebo-controlled, double-blind clinical study, we demonstrated that antifungal ciclopiroxolamine (CIC) 1% cream was effective in mild to moderate facial seborrheic dermatitis. " 01/01/2006 - "Varying frequencies and concentrations of ciclopirox shampoo have been shown to be effective and safe in the treatment of seborrheic dermatitis of the scalp." 03/01/2005 - "Ciclopirox olamine is a synthetic hydroxypiridone derived, broad spectrum, antifungal agent which has been used effectively to treat seborrheic dermatitis. " 07/01/2004 - "Ciclopirox shampoo 1% is effective and safe in the treatment of seborrheic dermatitis of the scalp." 09/01/2003 - "Ciclopirox gel is effective and safe in the treatment of seborrheic dermatitis of the scalp."
2.	pimecrolimus (Elidel)FDA Link 08/01/2007 - "This study suggests that pimecrolimus cream 1% is an effective and well-tolerated treatment for moderate to severe facial seborrheic dermatitis." 01/01/2012 - "Pimecrolimus 1% cream appears to be a well-tolerated and effective treatment for seborrheic dermatitis. " 01/01/2010 - "Pimecrolimus 1% cream is an effective and well tolerated treatment for seborrheic dermatitis. " 01/01/2004 - "Pimecrolimus cream 1% can be an effective treatment for seborrheic dermatitis of the face and trunk." 03/01/2010 - "Experience with repetitive use of pimecrolimus: exploring the effective and safe use in the treatment of relapsing seborrheic dermatitis."
3.	Ketoconazole (Nizoral)FDA LinkGeneric 06/01/2007 - "These data suggest that once-daily ketoconazole gel 2% is an effective treatment for seborrheic dermatitis and a viable alternative to the ketoconazole cream 2% formulation." 09/01/2006 - "This multicentre, single-blind, clinical study was conducted to evaluate the efficacy of a shampoo containing the 1.5% CPO/1% ZP association compared to the vehicle shampoo and to 2% ketoconazole foaming gel in the treatment of seborrheic dermatitis. " 01/01/2013 - "Long-term safety of ketoconazole foam, 2% in the treatment of seborrheic dermatitis: results of a phase IV, open-label study." 06/01/2007 - "Three randomized, double-blinded, vehicle-controlled, multicenter, parallel-group phase 3 studies evaluated the efficacy and tolerability of ketoconazole gel 2% compared with a vehicle gel in more than 900 subjects with moderate to severe seborrheic dermatitis who applied treatment for 14 days and were followed for an additional 14 days. " 07/01/2006 - "Efficacy and safety of a new once-daily topical ketoconazole 2% gel in the treatment of seborrheic dermatitis: a phase III trial."
4.	Metronidazole (Metric)FDA LinkGeneric 03/01/2007 - "Recently, two placebo-controlled studies have shown that topical metronidazole was effective in the treatment of seborrheic dermatitis. " 07/01/2006 - "Metronidazole gel is an effective treatment for facial seborrheic dermatitis." 08/01/2003 - "Is topical metronidazole effective in seborrheic dermatitis? " 07/01/2006 - "To evaluate the efficacy of 1% metronidazole gel and its vehicle alone, in the treatment of seborrheic dermatitis. " 07/01/2006 - "The efficacy of 1% metronidazole gel in facial seborrheic dermatitis: a double blind study."
5.	sertaconazoleFDA Link 01/01/2013 - "This study suggests that sertaconazole 2% cream is an effective and well-tolerated treatment for moderate to severe facial seborrheic dermatitis." 08/01/2011 - "An open-label study of the safety and efficacy of sertaconazole nitrate in the treatment of seborrheic dermatitis." 08/01/2011 - "The results of this preliminary study support the efficacy and safety of sertaconazole nitrate cream, 2%, for the treatment of seborrheic dermatitis." 01/01/2013 - "Sertaconazole 2% cream may be an excellent alternative therapeutic modality for treating seborrheic dermatitis." 01/01/2013 - "Considering its efficacy, safety, and acceptability profiles, sertaconazole 2% cream is a worthwhile alternative to existing antifungal therapies for the treatment of seborrheic dermatitis."
6.	Fluconazole (Zonal)FDA LinkGeneric 01/01/2006 - "Fluconazole treatment in patients with seborrheic dermatitis proves to be successful, effective and safe." 09/01/1994 - "The oral triazole fluconazole is not particularly effective in the management of seborrheic dermatitis. " 01/01/2007 - "Efficacy of oral fluconazole in the treatment of seborrheic dermatitis: a placebo-controlled study." 01/01/2006 - "We compared two study groups of patients: Group I--27 patients with seborrheic dermatitis stage I, II and III, treated with fluconazole, 50 mg/day for two weeks. " 01/01/2006 - "The purpose of the present study was to monitor the therapeutic effects of the anti-fungal drug fluconazole in patients with seborrheic dermatitis. "
7.	Adrenal Cortex Hormones (Corticosteroids)IBA 11/01/2009 - "Topical corticosteroids are effective for the treatment of seborrheic dermatitis. " 03/01/2000 - "Antifungal therapy is effective in the treatment of seborrheic dermatitis and, because it reduces the number of Malassezia, the time to recurrence is increased compared with treatment with corticosteroids. " 03/01/2000 - "Mild corticosteroids are effective in the treatment of seborrheic dermatitis. " 05/01/1983 - "Patients with seborrheic dermatitis responded well to treatment with antiseborrheic shampoo and topical corticosteroids. " 09/01/1999 - "The present study compared the early response of seborrheic dermatitis to two topical corticosteroids using objective quantifications of the stratum corneum alterations. "
8.	zinc pyrithione (ZPT)FDA Link 03/01/2009 - "Previous studies have shown that topical steroid and shampoo containing zinc pyrithione provide clinical benefits for treatment of scalp seborrheic dermatitis. " 01/01/2009 - "Does tachyphylaxis occur in long-term management of scalp seborrheic dermatitis with pyrithione zinc-based treatments?" 11/01/2002 - "It is concluded that after a 4-week treatment, KET 2% shampoo was significantly superior to ZPT 1% shampoo in the treatment of subjects with severe dandruff or seborrheic dermatitis of the scalp. " 11/01/2002 - "We compared the efficacy and safety of KET 2% and ZPT 1% in shampoo formulations for the alleviation of severe dandruff and seborrheic dermatitis. " 12/01/2006 - "In conclusion, this study demonstrates the in vitro inhibitory and fungicidal efficacy of the ciclopirox olamine/zinc pyrithione association against Malassezia species and underscores its potential interest in the treatment of seborrheic dermatitis."
9.	Itraconazole (Sporanox)FDA LinkGeneric 06/01/2008 - "In this study initial treatment with itraconazole was beneficial in patients with moderate to severe seborrheic dermatitis." 10/01/2015 - "Efficacy of Oral Itraconazole in the Treatment and Relapse Prevention of Moderate to Severe Seborrheic Dermatitis: A Randomized, Placebo-Controlled Trial." 01/01/2012 - "After six-week treatment with itraconazole administered daily at a dose of 200 mg using pulse therapy, there was remission of the disease or at least substantial clinical improvement in the patients with seborrheic dermatitis. " 06/01/2008 - "To evaluate the efficacy of itraconazole in the treatment of mild to severe facial seborrheic dermatitis. " 06/01/2008 - "Treatment of moderate to severe facial seborrheic dermatitis with itraconazole: an open non-comparative study."
10.	Hydrocortisone (Cortisol)FDA LinkGeneric 01/01/2013 - "The aim of the study is to compare the efficacy of sertaconazole 2% cream with hydrocortisone 1% cream in the treatment of seborrheic dermatitis. " 06/01/2013 - "Comparing the efficacy of Emu oil with clotrimazole and hydrocortisone in the treatment of seborrheic dermatitis: A clinical trial." 09/01/2004 - "To compare efficacy of 2% ketoconazole cream with 1% hydrocortisone cream in the treatment of infantile seborrheic dermatitis (ISD). " 01/01/2013 - "Clinical study of sertaconazole 2% cream vs. hydrocortisone 1% cream in the treatment of seborrheic dermatitis." 05/01/2014 - "Our first impression was seborrheic dermatitis and she was treated with facial cleanser soap and topic hydrocortisone 1%. "

Therapies and Procedures

1.	Off-Label Use 01/01/2009 - "Pimecrolimus was found to be effective for the treatment of seborrheic dermatitis in several studies and its off-label use is increasing gradually. "
2.	Skin Care 01/01/2011 - "Improved skin care practices and treatment with azelaic acid 15% gel twice daily in combination with low-dosage oral isotretinoin resulted in improvement in symptoms of both rosacea and seborrheic dermatitis. "
3.	Organ Transplantation 05/01/2010 - "No studies have looked at Seborrheic dermatitis in the context of immunosuppression secondary to organ transplantation. " 08/01/2005 - "Physiological and pharmacological actions of 1,25-(OH)(2)D(3) in various systems, along with the detection of VDR in target cells, have indicated potential therapeutic applications of VDR ligands in inflammation (rheumatoid arthritis, psoriatic arthritis), dermatological indications (psoriasis, actinic keratosis, seborrheic dermatitis, photoaging), osteoporosis (postmenopausal and steroid-induced osteoporosis), cancers (prostate, colon, breast, myelodysplasia, leukemia, head and neck squamous cell carcinoma, and basal cell carcinoma), secondary hyperparathyroidism, and autoimmune diseases (systemic lupus erythematosus, type I diabetes, multiple sclerosis, and organ transplantation). "
4.	Contraception (Birth Control) 10/01/2003 - "This was an open, noncomparative, bicenter study in 60 healthy Russian women, aged 18-30 years, with facial seborrhea and mild or moderate facial acne, who wished to use oral contraception. "
5.	Traction 06/01/2015 - "These disorders include central centrifugal cicatricial alopecia, dissecting cellulitis, discoid lesions of lupus erythematosus, traction alopecia, seborrheic dermatitis, and hair breakage. " 04/01/2013 - "These structural variations of the hair are closely linked to the common disorders of the hair and scalp, such as acquired trichorrhexis nodosa, seborrheic dermatitis, traction alopecia, central centrifugal cicatricial alopecia, dissecting cellulitis, frontal fibrosing alopecia, and pseudofolliculitis barbae." 02/01/2011 - "We sought to determine the prevalence of hair care practices and their association with traction alopecia, seborrheic dermatitis (SD), and tinea capitis (TC). " 09/01/2007 - "Therefore, the traction continues, as will the alopecia, possibly accompanied by seborrheic dermatitis and psoriasis."