Seborrheic Dermatitis

A chronic inflammatory disease of the skin with unknown etiology. It is characterized by moderate ERYTHEMA, dry, moist, or greasy (SEBACEOUS GLAND) scaling and yellow crusted patches on various areas, especially the scalp, that exfoliate as dandruff. Seborrheic dermatitis is common in children and adolescents with HIV INFECTIONS.

Also Known As:

Networked: 725 relevant articles (111 outcomes, 120 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Acne Vulgaris
2.	Hirsutism
3.	Psoriasis (Pustulosis Palmaris et Plantaris)
4.	Atopic Dermatitis (Atopic Eczema)
5.	Seborrheic Dermatitis

Experts

1.	Lee, Yang Won: 11 articles (01/2020 - 03/2009)
2.	Zouboulis, Christos C: 8 articles (01/2021 - 05/2002)
3.	Ahn, Kyu Joong: 7 articles (10/2017 - 03/2009)
4.	Choe, Yong Beom: 7 articles (10/2017 - 03/2009)
5.	Goldust, Mohamad: 7 articles (06/2013 - 01/2013)
6.	Gupta, Aditya K: 7 articles (10/2007 - 07/2003)
7.	Jung, Won Hee: 6 articles (01/2020 - 08/2013)
8.	Rezaee, Elham: 6 articles (05/2013 - 01/2013)
9.	Warshaw, Erin M: 5 articles (01/2022 - 08/2007)
10.	Clavaud, Cécile: 4 articles (05/2022 - 05/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Seborrheic Dermatitis:

1.	Ciclopirox (Loprox)FDA LinkGeneric 01/01/2006 - "Varying frequencies and concentrations of ciclopirox shampoo have been shown to be effective and safe in the treatment of seborrheic dermatitis of the scalp." 01/01/2003 - "In a placebo-controlled, double-blind clinical study, we demonstrated that antifungal ciclopiroxolamine (CIC) 1% cream was effective in mild to moderate facial seborrheic dermatitis. " 07/01/2004 - "Ciclopirox shampoo 1% is effective and safe in the treatment of seborrheic dermatitis of the scalp." 09/01/2003 - "Ciclopirox gel is effective and safe in the treatment of seborrheic dermatitis of the scalp." 07/01/2004 - "Safety and efficacy of ciclopirox 1% shampoo for the treatment of seborrheic dermatitis of the scalp in the US population: results of a double-blind, vehicle-controlled trial."
2.	pimecrolimus (Elidel)FDA Link 08/01/2007 - "This study suggests that pimecrolimus cream 1% is an effective and well-tolerated treatment for moderate to severe facial seborrheic dermatitis." 01/01/2012 - "Pimecrolimus 1% cream appears to be a well-tolerated and effective treatment for seborrheic dermatitis. " 01/01/2010 - "Pimecrolimus 1% cream is an effective and well tolerated treatment for seborrheic dermatitis. " 01/01/2004 - "Pimecrolimus cream 1% can be an effective treatment for seborrheic dermatitis of the face and trunk." 02/01/2018 - "Pimecrolimus 1% cream has already been proved to be an effective and safe alternative to treat seborrheic dermatitis. "
3.	Ketoconazole (Nizoral)FDA LinkGeneric 06/01/2007 - "These data suggest that once-daily ketoconazole gel 2% is an effective treatment for seborrheic dermatitis and a viable alternative to the ketoconazole cream 2% formulation." 09/01/2006 - "This multicentre, single-blind, clinical study was conducted to evaluate the efficacy of a shampoo containing the 1.5% CPO/1% ZP association compared to the vehicle shampoo and to 2% ketoconazole foaming gel in the treatment of seborrheic dermatitis. " 11/01/2022 - "Prospective, Open-Label, Multi-Centre, Randomized Study to Compare the Effectiveness, Safety, and Tolerability of Lulican™ Shampoo Versus Ketoconazole Shampoo in Indian Adult Patients With Mild to Moderate Scalp Seborrheic Dermatitis (LEAD Study)." 09/05/2016 - "The study results showed that there was little systemic absorption of ketoconazole in patients for the two formulations, and the ketoconazole foam and lotion are safe therapeutic drugs for seborrheic dermatitis patients. " 02/01/2016 - "The aim of this study was to assess the efficacy and tolerability of a combination noncorticosteroid, antiinflammatory/antifungal shampoo versus 1% ketoconazole shampoo in the treatment of mild-to-moderate scalp seborrheic dermatitis (SD). "
4.	sertaconazoleFDA Link 01/01/2013 - "This study suggests that sertaconazole 2% cream is an effective and well-tolerated treatment for moderate to severe facial seborrheic dermatitis." 08/01/2011 - "An open-label study of the safety and efficacy of sertaconazole nitrate in the treatment of seborrheic dermatitis." 09/19/2022 - "We performed an extensive literature search by browsing the PubMed database with the keyword combination "sertaconazole AND seborrheic dermatitis AND clinical trial", which retrieved eight controlled clinical trials evaluating the effects of sertaconazole in SD. " 08/01/2011 - "The results of this preliminary study support the efficacy and safety of sertaconazole nitrate cream, 2%, for the treatment of seborrheic dermatitis." 05/06/2013 - "Conclusion: Sertaconazole 2% cream may be an excellent alternative therapeutic modality for treating seborrheic dermatitis."
5.	Adrenal Cortex Hormones (Corticosteroids)IBA 11/01/2009 - "Topical corticosteroids are effective for the treatment of seborrheic dermatitis. " 03/01/2000 - "Mild corticosteroids are effective in the treatment of seborrheic dermatitis. " 11/01/2009 - "This study compared the efficacy of a nonsteroidal topical cream and a low-potency topical corticosteroid for the treatment of mild to moderate seborrheic dermatitis of the face in 77 volunteers randomized to twice-daily treatment with nonsteroidal cream or corticosteroid cream for up to 28 days. " 05/01/1983 - "Patients with seborrheic dermatitis responded well to treatment with antiseborrheic shampoo and topical corticosteroids. " 11/01/2009 - "This study assessed the antifungal activity of a new corticosteroid-free cream against Malassezia spp, which may be an important pathogenic factor in seborrheic dermatitis. "
6.	Isotretinoin (Accutane)FDA LinkGeneric 12/01/2003 - "Very low dose isotretinoin is effective in controlling seborrhea." 06/01/2023 - "There are few studies on oral isotretinoin in the treatment of seborrheic dermatitis. " 05/01/2023 - "To our knowledge, only one study has provided evidence of isotretinoin-induced seborrheic dermatitis-like eruptions. " 11/01/2023 - "Isotretinoin for the management of moderate-to-severe seborrheic dermatitis: A systematic review." 06/01/2023 - "When considering efficacy and safety, oral isotretinoin can be used to treat patients with moderate to severe seborrheic dermatitis."
7.	Metronidazole (Metric)FDA LinkGeneric 03/01/2007 - "Recently, two placebo-controlled studies have shown that topical metronidazole was effective in the treatment of seborrheic dermatitis. " 07/01/2006 - "Metronidazole gel is an effective treatment for facial seborrheic dermatitis." 08/01/2003 - "Is topical metronidazole effective in seborrheic dermatitis? " 07/01/2006 - "To evaluate the efficacy of 1% metronidazole gel and its vehicle alone, in the treatment of seborrheic dermatitis. " 07/01/2006 - "The efficacy of 1% metronidazole gel in facial seborrheic dermatitis: a double blind study."
8.	Itraconazole (Sporanox)FDA LinkGeneric 06/01/2008 - "In this study initial treatment with itraconazole was beneficial in patients with moderate to severe seborrheic dermatitis." 01/30/2019 - "This longitudinal study aims to evaluate the efficacy of oral itraconazole in the treatment of seborrheic dermatitis in Vietnamese patients. " 01/30/2019 - "Efficacy of Oral Itraconazole in the Treatment of Seborrheic Dermatitis in Vietnamese Adults Patients." 06/01/2008 - "To evaluate the efficacy of itraconazole in the treatment of mild to severe facial seborrheic dermatitis. " 07/01/2016 - "Effect of itraconazole on the quality of life in patients with moderate to severe seborrheic dermatitis: a randomized, placebo-controlled trial."
9.	Fluconazole (Zonal)FDA LinkGeneric 01/01/2006 - "Fluconazole treatment in patients with seborrheic dermatitis proves to be successful, effective and safe." 01/01/2007 - "Efficacy of oral fluconazole in the treatment of seborrheic dermatitis: a placebo-controlled study." 01/01/2006 - "We compared two study groups of patients: Group I--27 patients with seborrheic dermatitis stage I, II and III, treated with fluconazole, 50 mg/day for two weeks. " 01/01/2006 - "Fluconazole and its place in the treatment of seborrheic dermatitis--new therapeutic possibilities." 02/01/1994 - "Facial seborrheic dermatitis treated with fluconazole 2% shampoo."
10.	pyrithione zinc (ZPT)FDA Link 01/01/2018 - "Conclusion: The study showed that the herbal zinc pyrithione shampoo and scalp lotion provided improvement in the main symptoms of seborrheic dermatitis." 01/01/2009 - "Does tachyphylaxis occur in long-term management of scalp seborrheic dermatitis with pyrithione zinc-based treatments?" 01/01/2017 - "Zinc pyrithione (ZP) is commonly used to prevent dandruff and seborrheic dermatitis. " 02/01/2016 - "Zinc pyrithione (ZPT) is an active material that has been used for over 50 years to effectively treat dandruff and seborrheic dermatitis (D/SD). " 11/01/2002 - "It is concluded that after a 4-week treatment, KET 2% shampoo was significantly superior to ZPT 1% shampoo in the treatment of subjects with severe dandruff or seborrheic dermatitis of the scalp. "

Therapies and Procedures

1.	Therapeutics 11/01/2020 - "Anti-fungal therapy is beneficial for patients with seborrheic dermatitis. " 01/01/2004 - "Essentially, antifungal therapy reduces the number of yeasts on the skin, leading to an improvement in seborrheic dermatitis. " 07/01/2016 - "Few studies have examined the effect of seborrheic dermatitis (SD) and/or its consequent therapy on a patient's quality of life. " 11/01/2023 - "Forty male and female patients with clinically diagnosed seborrheic dermatitis of the scalp in the age 18-45 years, not satisfactorily responding to standard therapy for at least 6 months, were included. " 04/01/2023 - "Seborrheic dermatitis: topical therapeutics and formulation design."
2.	Lasers (Laser) 06/01/2022 - "The sebaceous gland secretion of seborrhea and multiplying of epidermal parasitic microbiological are inhibited after laser treatment. " 06/01/2022 - "In terms of skin barrier function, there are significant changes regarding transepidermal water loss and epidermal seborrhea content in observation group after the laser treatments. " 02/01/2014 - "Utilization of matrix-assisted laser desorption and ionization time-of-flight mass spectrometry for identification of infantile seborrheic dermatitis-causing Malassezia and incidence of culture-based cutaneous Malassezia microbiota of 1-month-old infants." 12/01/2018 - "This novel dual regimen of the 1450-nm laser demonstrated improved efficacies for acne and seborrhea with satisfactory safety profiles. " 01/01/2022 - "Further recommendations focus on the treatment of skin lesions without an increased amount of melanocytes (ephelides, postinflammatory hyperpigmentation including berloque dermatitis, seborrheic keratoses, traumatic/decorative tattoos and metallic deposits), hypopigmentation (vitiligo), benign non-pigmented neoplasms (fibrous papule of the nose, nevus sebaceus, epidermal nevus, neurofibroma, sebaceous gland hyperplasia, syringoma, xanthelasma palpebrarum), inflammatory dermatoses (acne papulopustulosa/conglobata, acne inversa, granuloma faciale, lichen sclerosus, lupus erythematosus, psoriasis vulgaris, rosacea, rhinophyma), wrinkles/dermatochalasis/striae, hypertrichosis, scars (atrophic, hypertrophic; keloids, burn/scald scars), laser-assisted skin healing, onychomycosis, precancerous lesions and malignant tumors (actinic keratoses/field cancerization, cheilitis actinica, basal cell carcinoma), vascular skin lesions (angiokeratoma, angioma, hemangioma, malformation, spider veins, granuloma telangiectaticum (pyogenic granuloma), rubeosis (erythrosis interfollicularis colli, ulerythema ophryogenes), nevus flammeus, telangiectasias and Osler's disease (hereditary hemorrhagic telangiectasia) and viral skin lesions (condylomata acuminata, mollusca contagiosa, verrucae planae juveniles/vulgares/ verrucae palmares et plantares)."
3.	Off-Label Use 01/01/2023 - "This narrative review focuses on the novel and off-label use of biologic medications for the management of hidradenitis suppurativa (HS), pyoderma gangrenosum (PG), lichen planus (LP), and seborrheic dermatitis (SD). " 01/01/2009 - "Pimecrolimus was found to be effective for the treatment of seborrheic dermatitis in several studies and its off-label use is increasing gradually. " 05/01/2020 - "This paper reviews the current, albeit limited, evidence for off-label use of crisaborole for psoriasis, seborrheic dermatitis, vitiligo, and inflammatory linear verrucous epidermal nevus. "
4.	Secondary Prevention 10/01/2015 - "Efficacy of Oral Itraconazole in the Treatment and Relapse Prevention of Moderate to Severe Seborrheic Dermatitis: A Randomized, Placebo-Controlled Trial."
5.	Intradermal Injections 11/01/2021 - "The efficacy of intradermal injections of botulinum toxin in the management of enlarged facial pores and seborrhea: a split face-controlled study."