Scurvy (Scorbutus)

An acquired blood vessel disorder caused by severe deficiency of vitamin C (ASCORBIC ACID) in the diet leading to defective collagen formation in small blood vessels. Scurvy is characterized by bleeding in any tissue, weakness, ANEMIA, spongy gums, and a brawny induration of the muscles of the calves and legs.

Also Known As:

Scorbutus; Hypoascorbemia; Hypoascorbemias; Scurvies

Networked: 741 relevant articles (23 outcomes, 38 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Ascorbic Acid Deficiency (Vitamin C Deficiency)
2.	Rickets (Rachitis)
3.	Hemorrhage
4.	Arthritis (Polyarthritis)
5.	Metabolic Diseases (Metabolic Disease)

Experts

1.	Lykkesfeldt, Jens: 4 articles (01/2020 - 01/2009)
2.	Tveden-Nyborg, Pernille: 3 articles (05/2021 - 01/2009)
3.	Carr, Anitra C: 3 articles (07/2020 - 01/2013)
4.	Harrison, Fiona E: 3 articles (02/2015 - 08/2008)
5.	Horio, Fumihiko: 3 articles (01/2014 - 02/2003)
6.	De Buyzere, Marc L: 3 articles (09/2013 - 08/2007)
7.	Delanghe, Joris R: 3 articles (09/2013 - 08/2007)
8.	Langlois, Michel R: 3 articles (09/2013 - 08/2007)
9.	Ishigami, Akihito: 3 articles (07/2010 - 04/2006)
10.	Trapani, Sandra: 2 articles (02/2022 - 01/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Scurvy:

1.	Ascorbic Acid (Vitamin C)FDA LinkGeneric 09/01/2001 - "Scurvy has been known since ancient times, but the discovery of the link between the dietary deficiency of ascorbic acid and scurvy has dramatically reduced its incidence over the past half-century. " 02/06/2022 - "When suspected, the dosage of serum vitamin C is the diagnostic gold standard; furthermore, imaging studies, performed by an expert radiologist, can reveal the typical features of scurvy. " 01/01/2020 - "Deficiency in vitamin C results in the potentially fatal disease scurvy, which can be cured only by administering vitamin C. " 06/01/2009 - "With this paper we aimed to remind of the efficacy of vitamin C administration for patients with scurvy." 07/01/2003 - "Fortunately, individuals with scurvy, even those with advanced disease, respond favorably to administration of vitamin C."
2.	VitaminsIBA 11/01/2019 - "The discovery of beri-beri and scurvy vitamins - two hundred and two years from its discovery." 10/01/2018 - "We present a case of scurvy in a HD patient that will contribute toward the understanding of vitamin status in HD. " 04/11/2014 - "Scurvy in an alcoholic patient treated with intravenous vitamins." 08/01/2008 - "Scurvy, while uncommon, still occurs in developed countries despite the widespread availability of vitamins and fortified foods. " 02/14/2004 - "Scurvy can occur in hospitalized patients despite vitamin supplementation. "
3.	Insulin (Novolin)FDA Link 04/01/1998 - "If a rise in plasma ASC is uncoupled from insulin replacement in insulin-dependent diabetes mellitus (IDDM) then the degree of hyperglycemia could account for "tissue scurvy" in IDDM. " 01/01/1961 - "Effect of insulin on serum proteins in scurvy." 12/01/1952 - "Factors determining effect of insulin on metabolism of glucose in ascorbic acid deficiency and scurvy in the monkey." 02/01/1963 - "Plasma lipids in scurvy: effect of ascorbic acid supplement and insulin treatment." 04/01/1947 - "Relation of scurvy to glucose tolerance test, liver glycogen, and insulin content of pancreas of guinea pigs."
4.	Folic Acid (Vitamin M)FDA LinkGeneric 11/01/1961 - "In patients with scurvy, folic acid is cleared from the plasma abnormally rapidly. " 02/01/1975 - "Folate metabolism in scurvy." 11/01/1961 - "The folic acid clearance test of Chanarin (1958) has been studied in normal white subjects, patients with megaloblastic anaemia, healthy Bantu males, Bantu females, hospital patients without anaemia, and in patients with scurvy. " 03/01/1951 - "Lack of effect of folic acid on scurvy in guinea pigs." 04/01/1950 - "XII. Folic acid and experimental scurvy]."
5.	Hormones (Hormone)IBA 04/01/1986 - "Clinical manifestations of scurvy were exhibited, however, when animals receiving no ascorbic acid supplement were treated with the steroid hormones for 7 d. " 01/01/2014 - "The discovery of vitamins using rats has almost eliminated diseases such as scurvy and rickets; and hormones, such as insulin discovered following work in dogs, have helped to control many metabolic diseases. " 11/01/1948 - "Effect of insulin, adrenal cortical hormones, salt and dl-alanine on carbohydrate metabolism in scurvy."
6.	FlavonoidsIBA 01/01/2004 - "Biological activity of flavonoids was first suggested by Szent-Gÿorgyi 1938, who reported that citrus peel flavonoids were effective in preventing the capillary bleeding and fragility associated with scurvy. " 01/01/1961 - "[Scurvy, vitamin C and bioflavonoids (vitamin P)]."
7.	Selenic AcidIBA 03/08/2023 - "Multivitamins and sodium selenate were administered for 12 days during admission, and symptoms of selenium deficiency and scurvy improved. "
8.	Salicylic Acid (2 Hydroxybenzoic Acid)FDA LinkGeneric 07/01/1887 - "The Efficacy of Salicylic Acid in the Treatment of Scurvy."
9.	SeleniumIBA 03/08/2023 - "He was diagnosed with both selenium deficiency and scurvy. " 03/08/2023 - "We report a complicated case of both selenium deficiency and scurvy due to an imbalanced diet of snacks and lacto-fermenting drinks in a 7-year-old boy with autism spectrum disorder. " 03/08/2023 - "Selenium deficiency and scurvy due to an imbalanced diet of snacks and lacto-fermenting drinks: a case report of a 7-year-old boy with autism spectrum disorder." 03/08/2023 - "Multivitamins and sodium selenate were administered for 12 days during admission, and symptoms of selenium deficiency and scurvy improved. " 03/08/2023 - "There have been reports of isolated trace elements or vitamin deficiencies due to imbalanced diets, but no cases of selenium deficiency combined with scurvy have been reported. "
10.	Cod Liver OilIBA 02/01/2001 - "Availability of the home icebox permitted safe storage of milk and infant formula, and by the 1920s, feeding of orange juice and cod liver oil greatly decreased the incidence of scurvy and rickets. "

Therapies and Procedures

1.	Therapeutics 12/01/2021 - "Roncalli Parolino focused his study on the treatment of scurvy and he promoted the inclusion of the Greenlandic and Faroese therapy into the broader European context. " 08/02/2021 - "CONCLUSIONS This case shows that although the incidence of scurvy has been greatly reduced in Western Europe, this pathology can still manifest itself, especially in vulnerable children, and its prompt diagnosis and therapy are important considering the excellent response to treatment." 05/01/2003 - "Although efficient therapy of scurvy (fresh vegetables, lemon juice) was known in the mid-18th century, its etiology was not known. " 05/01/2003 - "[History of scurvy therapy and the injustice done to Dr. Maksim Nikolić-Miskovićev of Sremski Karlovci in the 19th century]." 08/09/1994 - "Historical data, pathogenesis, incidence, clinical presentation, diagnosis and therapy of scurvy are discussed. "
2.	Traditional Medicine (Folk Remedies) 03/11/2023 - "Salicornia is a halophyte plant that has been used in traditional medicine for the treatment of scurvy, goiter, and hypertension. " 03/01/2017 - "Garcinia dulcis (Roxb.) Kurz is a tropical fruit tree native to Southeast Asia where it has a long history of use as a traditional medicine for the treatment of ailments such as lymphatitis, parotitis, struma, scurvy, cough, and sore throat. " 04/24/2021 - "Hibiscus species (Family: Malvaceae) have long been used in traditional medicine to treat a variety of maladies such as abscesses, bilious conditions, cancer, cough, fatigue, gastrointestinal discomfort, fever, veisalgia, cardiovascular disorders, neurosis, scurvy, and urinary tract disorders. " 06/01/2014 - "(Salvadoraceae) have been used in folk medicine for the treatment of a wide range of medical problems such as cough, asthma, scurvy, piles, rheumatism, leprosy, and gonorrhea disorders. " 01/01/2021 - "In traditional medicine, WC is a known remedy for hypercholesterolemia, hyperglycemia, hypertension, arthritis, bronchitis, diuresis, odontalgia, and scurvy. "
3.	Diet Therapy (Therapy, Diet) 10/01/2001 - "Between 1907 and 1912, Holst and Frolich induced and cured scurvy in guinea pigs by dietary modification. " 01/01/2015 - "We describe two cases of pediatric scurvy in two 7-year-old boys who had dietary restrictions stemming from developmental disorders. " 01/01/2020 - "Scurvy secondary to dietary restrictions for renal calculi." 01/01/2018 - "The increasing popularity of dietary restriction for children, especially those with allergies, may potentially enhance the occurrence of scurvy in apparently healthy children. " 08/01/2021 - "We report a case of a 5-year-old patient with autism, who presented with scurvy secondary to the dietary restrictions of a ketogenic diet. "
4.	Liver Transplantation 05/01/2008 - "Scurvy diagnosed in a pediatric liver transplant patient awaiting combined kidney and liver retransplantation." 05/01/2008 - "Scurvy diagnosed in a pediatric liver transplant awaiting combined kidney and liver transplantation." 07/01/2006 - "We report on scurvy in 3 liver transplant recipients. " 07/01/2006 - "Scurvy in liver transplant patients." 05/15/2001 - "Hepatocyte and partial liver transplantation were evaluated in the scurvy-prone osteogenic disorder Shionogi rat model. "
5.	Aftercare (After-Treatment) 07/22/1967 - "Rapid reversion of electrocardiographic abnormalities after treatment in two cases of scurvy." 04/01/2022 - "Resolution of acquired palmoplantar keratoderma and scurvy after treatment of multivitamin deficiencies." 05/01/1994 - "A diagnosis of scurvy was made and the patient's disease resolved after treatment with vitamin C." 09/01/2001 - "The signs of scurvy and hypertension resolved after treatment with vitamin C. "