Sclerosing Solutions (Sclerosing Agents)

Chemical agents injected into blood vessels and lymphatic sinuses to shrink or cause localized THROMBOSIS; FIBROSIS, and obliteration of the vessels. This treatment is applied in a number of conditions such as VARICOSE VEINS; HEMORRHOIDS; GASTRIC VARICES; ESOPHAGEAL VARICES; PEPTIC ULCER HEMORRHAGE.

Also Known As:

Networked: 306 relevant articles (28 outcomes, 38 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Alfredson, Håkan: 9 articles (08/2015 - 03/2005)
2.	Ohberg, Lars: 7 articles (09/2008 - 03/2005)
3.	Bahr, Roald: 4 articles (03/2012 - 11/2006)
4.	Hoksrud, Aasne: 4 articles (03/2012 - 11/2006)
5.	Willberg, Lotta: 3 articles (08/2015 - 05/2007)
6.	Forssblad, Magnus: 3 articles (08/2015 - 05/2007)
7.	Sunding, Kerstin: 3 articles (08/2015 - 05/2007)
8.	Fahlström, Martin: 2 articles (08/2015 - 09/2008)
9.	Wooley, James R: 2 articles (07/2006 - 05/2005)
10.	Haldeman, Scott: 2 articles (07/2006 - 05/2005)

Related Diseases

1.	Hemorrhage 06/01/2007 - "Efficacy of local sclerosing agents on hemostasis of hepatic bleeding." 10/01/1999 - "The efficacy of paravascular injection of sclerosing agents for treating acute arterial bleeding, however, is not supported in this experimental model." 09/01/2002 - "The use of conventional sclerosing agents is associated with high rates of recurrent bleeding. " 10/01/1999 - "The pharmacologic response and microvascular effects associated with the endoscopic injection of sclerosing agents around vessels (paravascular injection) to stop bleeding from the digestive tract remain to be clarified. " 10/01/1999 - "Is endoscopic paravascular injection of sclerosing agents reasonable in the control of GI bleeding?"
2.	Esophageal and Gastric Varices (Esophageal Varices) 12/01/1992 - "This study suggests that the two sclerosants have equal efficacy for treating patients with esophageal varices. " 06/01/1992 - "Experimental study on the effects of sclerosants for esophageal varices on blood coagulation, fibrinolysis and systemic hemodynamics." 03/01/1990 - "A comparative evaluation of sclerosants for esophageal varices: a prospective randomized controlled study." 07/01/2004 - "These results were either equivalent to or significantly better than the most commonly used gastric varix hemostatic agent (glue) or other sclerosing agents. " 06/01/1992 - "The effects of five sclerosants used for treating esophageal varices on blood coagulation and fibrinolysis, systemic hemodynamics, and vascular endothelial cells were studied in mongrel dogs. "
3.	Varicose Veins (Varicose Vein) 08/01/1988 - "Trial of sclerosing agents in patients with oesophageal varices." 10/01/1965 - "[Preliminary phlebocinematographic study of sclerosing injections of varices]." 05/01/2004 - "The use of foamed sclerosing agents in therapy of large or small varicose veins is not new. " 10/01/1995 - "The usual method of injection of sclerosing agents is based simply on clinical recognition and visualization of the varicose vein. " 05/01/1994 - "Radical treatment of varicose veins, whether by sclerosing injections or surgery, depends upon the anatomical nature of lesions, the degree of venous incompetence and the extent of signs, but also the wishes of the patient, properly informed of the advantages and limitations of each technique."
4.	Tendinopathy (Tendonitis) 09/01/2008 - "Recent studies have revealed structural changes with neovessels in patients with jumper's knee and Achilles tendinopathy, and treatment with sclerosing injections has shown promising clinical results. " 08/01/2015 - "Treatment of patellar tendinopathy/jumper's knee with ultrasound-guided sclerosing injections or ultrasound-guided arthroscopic shaving has shown good clinical short-term results. " 08/01/2015 - "Sclerosing injections and ultrasound-guided arthroscopic shaving for patellar tendinopathy: good clinical results and decreased tendon thickness after surgery-a medium-term follow-up study." 09/01/2008 - "We conclude that sclerosing injections is a promising alternative to surgery in chronic Achilles midportion tendinosis. " 09/01/2008 - "Sclerosing injections in midportion Achilles tendinopathy: a retrospective study of 25 patients."
5.	Cysts 11/01/2004 - "As for the comparison between the two sclerosing agents, alcohol has a higher cost and negative side effects, but is more effective for the treatment of larger cysts. " 12/01/1996 - "The objective of this study is to evaluate the sclerosing agents for simple renal cysts. " 07/01/2012 - "High rates of cyst disappearance and long-lasting cyst volume reduction have been reported with the use of various sclerosants. " 04/01/2011 - "Current management includes percutaneous aspiration with instillation of sclerosing agents, wide excision or unroofing, or fenestration of the cyst wall (> 50%) either by open or laparoscopic surgery. " 01/01/2009 - "It is impossible to inject sclerosing agents into multiple cysts and surgical resection may sacrifice neighboring organs. "

Related Drugs and Biologics

1.	polidocanol (Laureth)
2.	Ethanol (Ethyl Alcohol)
3.	ethanolamine oleate (Ethamolin)
4.	Sodium
5.	Bleomycin (Blenoxane)
6.	Tetracycline (Achromycin)
7.	Nitric Oxide (Nitrogen Monoxide)
8.	Epinephrine (Adrenaline)
9.	Phenol (Carbolic Acid)
10.	Thiotepa (Triethylenethiophosphoramide)

Related Therapies and Procedures

1.	Sclerotherapy
2.	Injections
3.	Pleurodesis
4.	Ligation
5.	Drug Therapy (Chemotherapy)