Sizofiran (Schizophyllan)

09/01/1986 - "[Combination therapy of radiation and schizophyllan (SPG) in C3H mouse squamous-cell carcinoma NR-S1]."
01/01/1997 - "A phase II randomized controlled trial was carried out to evaluate the clinical efficacy and tolerability of Schizophyllan (SPG) used in combination with standard chemotherapy in the neoadjuvant setting in patients with locally advanced head and neck squamous cell carcinoma. "
01/01/1997 - "Clinical and immunological evaluation of schizophyllan (SPG) in combination with standard chemotherapy in patients with head and neck squamous cell carcinoma."
01/01/1992 - "The efficacy of Sizofiran(SPG), a highly purified beta-1,3-D-glucan from the culture broth of basidiomycetes Schizophyllum commune Fries, in combination with local irradiation was investigated using squamous-cell carcinoma NR-S1 and syngeneic hosts of C3H/He mice. "
09/01/1986 - "The efficacy of schizophyllan, a beta-1, 3-D-glucan with a beta-1, 6-linked D-glucose residue isolated from Schizophyllum commune Fries, in combination with local radiation therapy was investigated using C3H mouse squamous-cell carcinoma NR-S1. "

01/01/1993 - "Schizophyllan also augmented protective immune responses induced by low doses of a live Sendai virus vaccine that were insufficient to confer complete protection against challenge infection with a virulent strain. "
01/01/1993 - "The present results suggest that schizophyllan confers better protection against virus infection through augmentation of antiviral immune responses and can be used as an immune enhancer."
01/01/1997 - " results suggest that schizophyllan confers effective protection against viral infection by increasing antiviral immune responses, and that it could be used to boost immunity to virus infection in animals or in invertebrates."
01/01/1993 - "Antiviral antibody in the serum could be detected at an earlier time after virus infection and virus spread in the lung was more efficiently inhibited in schizophyllan-treated mice than in untreated controls. "
01/01/1993 - "When treated with fungal polysaccharide schizophyllan, mice survived otherwise lethal Sendai virus infection. "

02/01/1992 - "To evaluate the clinical effect of a biological response modifier (BRM), sizofiran (SPG), combined with irradiation, a randomized controlled study was performed in patients with stage II or III cervical cancer involving the collaboration of 52 institutes throughout Japan. "
02/01/1992 - "Clinical effect of sizofiran combined with irradiation in cervical cancer patients: a randomized controlled study. "
11/01/1990 - "[Studies on metabolism and disposition of sizofiran (SPG), an anti-tumor polysaccharide. "
02/01/1990 - "[Studies on metabolism and disposition of sizofiran (SPG), an anti-tumor polysaccharide. "
08/01/1988 - "[Studies on metabolism and disposition of sizofiran (SPG), an anti-tumor polysaccharide. "

10/20/1989 - "The immunological effect has been studied of the non-specific immunopotentiator sizofiran (SPG) on patients with advanced uterine cervical cancer treated with radiation. "
10/20/1989 - "[The cytoimmunological effect of concomitant use of sizofiran (SPG) on advanced uterine cervical cancer treated with radiation]."
11/20/1990 - "[The study on the immunological effect of sizofilan combined with radiotherapy in patients with uterine cervical cancer]."
07/01/1980 - "[Studies on immunotherapy of uterine cervical cancer by administration of schizophyllan (SPG) (author's transl)]."
11/20/1990 - "To investigate the immunological effect of Sizofilan (SPG) combined with radiotherapy, we evaluated the immunological parameters in 22 patients with uterine cervical cancers. "

01/01/1998 - "Augmentation of the antitumor effect of adoptive immunotherapy by in vivo sensitization of EL-4 lymphoma and pre-treatment with sizofiran."
01/01/1996 - "We have reported that combined administration with recombinant interleukin-2 (rIL-2) and sizofiran (SPG) is effective in prolonging survival time of C57BL/6 mice intraperitoneally inoculated with EL-4 lymphoma. "
01/01/1998 - "The antitumor effects of adoptive immunotherapy using LAK cells treated with sizofiran (SPG) following in vivo antigen sensitization with EL-4 lymphoma (EsLAK), comparing nonsensitized LAK cells (sLAK), were studied in mice with intraperitoneal implantation of EL-4 lymphoma. "
01/01/1996 - "The antitumor effect of the combined administration with recombinant human interleukin-2 (rIL-2) and sizofiran (SPG), a single glucan of Shizophyllum commune Fries, was studied in vivo in C57BL/6 mice intraperitoneally inoculated with EL-4 lymphoma. "
01/01/1996 - "Augmentation of antitumor effect by combined administration with interleukin-2 and sizofiran, a single glucan, on murine EL-4 lymphoma."