Disorganized Schizophrenia (Hebephrenic Schizophrenia)

A type of schizophrenia characterized by frequent incoherence; marked loosening of associations, or grossly disorganized behavior and flat or grossly inappropriate affect that does not meet the criteria for the catatonic type; associated features include extreme social withdrawal, grimacing, mannerisms, mirror gazing, inappropriate giggling, and other odd behavior. (Dorland, 27th ed)

Also Known As:

Networked: 17 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Spinocerebellar Degenerations (Marinesco Sjogren Syndrome)
2.	Sphingolipidoses (Sphingolipidosis)
3.	Paranoid Schizophrenia (Delusional Disorder)
4.	Schizophrenia (Dementia Praecox)
5.	Psychotic Disorders (Schizoaffective Disorder)

Experts

1.	Gahr, M: 2 articles (05/2014 - 03/2011)
2.	Dahan, Eyal: 1 article (01/2015)
3.	Or, Evgenia: 1 article (01/2015)
4.	Toteja, Nitin: 1 article (01/2015)
5.	Melamed, Yuval: 1 article (01/2015)
6.	Aboueid, Lila: 1 article (01/2015)
7.	Bleich, Avi: 1 article (01/2015)
8.	Leucht, S: 1 article (07/2014)
9.	Corves, C: 1 article (07/2014)
10.	Engel, R R: 1 article (07/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Disorganized Schizophrenia:

1.	Clozapine (Clozaril)FDA LinkGeneric 01/01/1999 - "The current study investigated the use of cohesive links analysis as a measure of Clozaril's efficacy in treating disorganized schizophrenia. " 01/01/1999 - "Phoricity as a measure of Clozaril's efficacy in treating disorganized schizophrenia." 10/01/2013 - "Although the difference was not significant, 80% of treatment-resistant patients with disorganized schizophrenia responded to clozapine. " 01/01/1978 - "The authors studied a prolonged (3--5 years) use of leponex in 23 patients with the most progressive forms of schizophrenia (hebephrenic, paranoid and close to them attack-like). " 01/01/2015 - "17-year-old Puerto Rican boy, with history of schizophrenia, disorganized type (treatment resistant), and intellectual disability, developed myocarditis on the thirteenth day following clozapine commencement. "
2.	sultopride (amisulpride)IBA 07/01/2014 - "The aim of this study was to compare the differential response to amisulpride in patients with paranoid versus disorganized schizophrenia. "
3.	Cannabinoid Receptors (Cannabinoid Receptor)IBA 04/05/2008 - "Cannabinoid receptor 1 gene (CNR1) and susceptibility to a quantitative phenotype for hebephrenic schizophrenia." 01/01/2002 - "CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia."
4.	Antipsychotic Agents (Antipsychotics)IBA 01/01/2015 - "We report the case of a patient suffering from disorganized schizophrenia who had life-threatening hematological side effects to treatment with antipsychotic agents. " 07/01/2014 - "Do patients with paranoid and disorganized schizophrenia respond differently to antipsychotic drugs?"
5.	Cytochrome P-450 CYP1A2 (CYP1A2)IBA 05/01/2014 - "Here we present the case of a 29-year-old female patient with disorganized schizophrenia who exhibited OCS due to fluvoxamine-induced elevation of CLZ serum levels via inhibition of CYP 1A2 und 2C19. "
6.	Dopamine Agonists (Dopamine Agonist)IBA 03/01/2011 - "Disorganized schizophrenia does not deteriorate with dopamine agonists cabergoline and bromocriptine used for ablactation."
7.	Fluvoxamine (Luvox)FDA LinkGeneric 05/01/2014 - "Here we present the case of a 29-year-old female patient with disorganized schizophrenia who exhibited OCS due to fluvoxamine-induced elevation of CLZ serum levels via inhibition of CYP 1A2 und 2C19. "
8.	N-Methylaspartate (NMDA)IBA 03/01/2013 - "Retrospectively, 2 patients initially classified as having catatonic or disorganized schizophrenia were reclassified as having misdiagnosed NMDA-R encephalitis (presence of specific serum and cerebrospinal fluid IgG NR1a antibodies). "
9.	Pimozide (Orap)FDA Link 01/01/2003 - "Pimozide augmentation of clozapine in hebephrenic schizophrenia: a case report."
10.	Monoamine Oxidase (MAO)IBA 10/01/1990 - "Platelet MAO activity appears to be related to subgroups of schizophrenia disorganized, catatonic and paranoid. "

Therapies and Procedures

1.	Nursing Care 06/21/1973 - "Nursing care study: hebephrenic schizophrenia."
2.	Drug Therapy (Chemotherapy) 01/01/2015 - "Considering the lack of controlled trials in this area, this case and other similar cases reported in the literature add support to a possible benefit of mECT in disorganized schizophrenia, particularly when pharmacotherapy is insufficient or contraindicated. "