Childhood Schizophrenia

An obsolete concept, historically used for childhood mental disorders thought to be a form of schizophrenia. It was in earlier versions of DSM but is now included within the broad concept of PERVASIVE DEVELOPMENT DISORDERS.

Also Known As:

Networked: 102 relevant articles (6 outcomes, 21 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Autistic Disorder (Autism)
2.	Myasthenia Gravis
3.	Mania (Manias)
4.	Psychotic Disorders (Schizoaffective Disorder)
5.	Schizophrenia (Dementia Praecox)

Experts

1.	Gogtay, Nitin: 14 articles (03/2013 - 01/2002)
2.	Rapoport, Judith L: 11 articles (01/2016 - 01/2002)
3.	Greenstein, Deanna: 7 articles (03/2013 - 07/2006)
4.	Weizman, Abraham: 6 articles (01/2015 - 01/2003)
5.	Tossell, Julia W: 5 articles (03/2013 - 01/2004)
6.	Rapoport, Judith: 5 articles (10/2011 - 02/2008)
7.	Gochman, Peter: 4 articles (01/2016 - 01/2004)
8.	Ebert, Tanya: 4 articles (01/2015 - 08/2006)
9.	Spivak, Baruch: 4 articles (01/2015 - 01/2003)
10.	Miller, Rachel: 4 articles (03/2013 - 10/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Childhood Schizophrenia:

1.	Olanzapine (Zyprexa)FDA Link 01/01/2003 - "Olanzapine appears useful in the treatment of childhood-onset schizophrenia, although there may be a delayed onset of benefit for anxiety and negative symptoms. " 04/01/1998 - "This pilot study examined the efficacy of olanzapine for treatment-refractory childhood-onset schizophrenia in eight patients who had received 8-week open-label trials. " 01/01/2003 - "Olanzapine treatment in chronic drug-resistant childhood-onset schizophrenia: an open-label study." 01/01/2003 - "To determine the response of children with childhood-onset schizophrenia to a 1-year prospective, open-label trial of olanzapine. " 04/01/1998 - "Childhood-onset schizophrenia: an open-label study of olanzapine in adolescents."
2.	Antipsychotic Agents (Antipsychotics)IBA 12/01/1998 - "Some of the atypical neuroleptics may become the first-line treatment for childhood schizophrenia and pervasive developmental disorders." 01/01/2004 - "Further double-blind, placebo-controlled trials and long-term safety assessments are needed before definitive conclusions can be reached about the place of atypical antipsychotics in the therapeutic armamentarium of childhood-onset schizophrenia." 06/01/2013 - "Unremitting impulsive aggression in a child with childhood onset schizophrenia and pervasive development disorder-not otherwise specified: the role of stimulants, atypical antipsychotics and mood stabilizers." 08/01/2008 - "This review encompasses and elaborates on the efficacy, safety and tolerability data available at present for both typical and atypical antipsychotics for treatment of childhood schizophrenia. " 09/01/2007 - "Antipsychotic medication for childhood-onset schizophrenia."
3.	Clozapine (Clozaril)FDA LinkGeneric 01/01/2023 - "Clozapine reduces the severity of resistant childhood schizophrenia, aggression, suicidality, and severe non-psychotic illness. " 02/01/2008 - "Available studies in the literature using clozapine in the pediatric population are summarized and the NIMH experience in treating refractory childhood-onset schizophrenia cases with clozapine is discussed. " 06/01/1994 - "To review the response of 11 adolescents with childhood-onset schizophrenia to a 6-week open clozapine trial. " 06/01/1994 - "An open trial of clozapine in 11 adolescents with childhood-onset schizophrenia." 01/01/2016 - "Strong Treatment Response and High Maintenance Rates of Clozapine in Childhood-Onset Schizophrenia."
4.	Neostigmine (Neostigmine Bromide)IBA 09/01/1977 - "Coexisting childhood schizophrenia and myasthenia gravis treated successfully with neostigmine bromide."
5.	Haloperidol (Haldol)FDA LinkGeneric 11/01/2004 - "Because the diagnostic of childhood-onset schizophrenia was suspected, a neuroleptic treatment, haloperidol 3 mg/day, was tried. " 09/01/1994 - "Plasma clozapine and haloperidol concentrations were studied in adolescents being treated for childhood-onset schizophrenia. " 09/01/1994 - "Plasma clozapine and haloperidol concentrations in adolescents with childhood-onset schizophrenia: association with response." 07/18/2007 - "A few results from one study favoured the atypical antipsychotic clozapine over haloperidol in treating treatment resistant childhood-onset schizophrenia (n=21, WMD CGAS 17.00 CI 7.74 to 26.26; n=21, WMD Bunney-Hamburg Psychosis Rating Scale -3.60 CI -6.64 to -0.56). " 01/01/1999 - "The National Institute of Mental Health patients--13 females, 22 males (mean age, 14.1+/-2.3 years; range, 9.1-19 years) with childhood onset schizophrenia (n = 32), or Psychotic Disorder not otherwise specified (NOS) (n = 3) with onset of psychosis before age 13--were recruited for open or double-blind trials of haloperidol, clozapine, or olanzapine. "
6.	PotassiumIBA 01/01/1973 - "Studies on erythrocyte magnesium and potassium levels in childhood schizophrenia and growth." 04/01/1969 - "Studies on erythrocyte magnesium and potassium levels in childhood schizophrenia and growth." 09/01/1984 - "[Effect of increased levels of trace elements in the blood on erythrocyte membrane permeability to sodium and potassium ions in childhood schizophrenia]."
7.	MagnesiumIBA 10/01/1971 - "Serum magnesium differences: further evidence for discontinuity between adult and childhood schizophrenia." 01/01/1973 - "Studies on erythrocyte magnesium and potassium levels in childhood schizophrenia and growth." 04/01/1969 - "Studies on erythrocyte magnesium and potassium levels in childhood schizophrenia and growth."
8.	Serotonin (5 Hydroxytryptamine)IBA 01/01/1971 - "Biological studies in childhood schizophrenia: serotonin uptake by platelets." 01/01/1977 - "Previous work indicated a platelet abnormality in the in vitro accumulation of serotonin in childhood schizophrenia, especially infantile autism. " 01/01/1977 - "Uptake of 5-hydroxytryptamine by isolated platelets in childhood schizophrenia and autism."
9.	Protons (Proton)IBA 04/01/2004 - "This study used proton magnetic resonance spectroscopic imaging ((1)H MRSI) to identify potential metabolic abnormalities in these regions in childhood-onset schizophrenia. " 12/01/2011 - "Proton magnetic resonance spectroscopy and thought disorder in childhood schizophrenia."
10.	Proteins (Proteins, Gene)FDA Link 06/01/2005 - "In the present study, SNPs in and around the GAD1 gene, which encodes the protein GAD67, were tested on a rare, severely ill group of children and adolescents with childhood-onset schizophrenia (COS) (n=72), in a family-based association analysis. "

Therapies and Procedures

1.	Transcranial Direct Current Stimulation 10/01/2011 - "This study aims to investigate the tolerability aspects of tDCS in the childhood-onset schizophrenia (COS) population. " 10/01/2011 - "Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia."
2.	Therapeutics 01/01/1986 - "Prospects of secondary (therapeutic) prophylaxis of childhood schizophrenia are steadily improving due to the breakthroughs of modern therapy." 01/01/1977 - "Due to the multifacet genesis and variability of clinical phenomenology, the therapy of childhood schizophrenia must be multidimensional. " 01/01/1977 - "[Therapy of childhood schizophrenia]."
3.	Play Therapy (Therapy, Play) 07/01/1971 - "Relative effectiveness of operant conditioning and play therapy in childhood schizophrenia."
4.	Language Therapy (Language Training) 11/01/1973 - "Language therapy in childhood schizophrenia: a case study of a monitoring and feedback approach."