Schistosomiasis mansoni

Schistosomiasis caused by Schistosoma mansoni. It is endemic in Africa, the Middle East, South America, and the Caribbean and affects mainly the bowel, spleen, and liver.

Also Known As:

Schistosoma mansoni Infection; Infection, Schistosoma mansoni; Infections, Schistosoma mansoni; Intestinal Schistosomiases; Intestinal Schistosomiasis; Schistosoma mansoni Infections; Schistosomiases, Intestinal; Schistosomiasis, Intestinal

Networked: 1486 relevant articles (101 outcomes, 202 trials/studies)

Relationship Network

Disease Context: Research Results

Infections: 526564
- Parasitic Diseases: 4870
  - Helminthiasis: 527
    - Trematode Infections: 111
      - Schistosomiasis: 5659
        Schistosomiasis mansoni: 1486
- Vector Borne Diseases: 374
  - Schistosomiasis: 5659
    - Schistosomiasis mansoni: 1486

Related Diseases

1.	Infections
2.	Schistosomiasis (Bilharziasis)
3.	Reinfection
4.	Malnutrition (Nutritional Deficiencies)
5.	Fibrosis (Cirrhosis)

Experts

1.	Kabatereine, Narcis B: 26 articles (04/2019 - 01/2004)
2.	Stothard, J Russell: 21 articles (01/2021 - 02/2006)
3.	Dunne, David W: 14 articles (09/2014 - 01/2004)
4.	van Dam, Govert J: 12 articles (02/2022 - 01/2013)
5.	Coelho, Paulo Marcos Zech: 12 articles (01/2022 - 05/2006)
6.	Mwinzi, Pauline N M: 12 articles (12/2017 - 10/2007)
7.	Colley, Daniel G: 11 articles (01/2020 - 04/2002)
8.	Karanja, Diana M S: 11 articles (01/2020 - 10/2007)
9.	Vennervald, Birgitte J: 11 articles (11/2017 - 01/2004)
10.	Lambertucci, José Roberto: 10 articles (10/2021 - 09/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Schistosomiasis mansoni:

1.	Praziquantel (Biltricide)FDA Link 12/01/2022 - "Limited efficacy of repeated praziquantel treatment in Schistosoma mansoni infections as revealed by highly accurate diagnostics, PCR and UCP-LF CAA (RePST trial)." 07/01/2002 - "The efficacy of praziquantel against schistosomiasis mansoni has been measured in 10-14 years old schoolchildren in a highly endemic area of north-west Ethiopia. " 10/01/1990 - "Praziquantel, administered over a 72 h period in the food of mature Biomphalaria glabrata harbouring 7-week-old Schistosoma mansoni infections, dramatically reduced the numbers of cercariae shed. " 01/01/2023 - "Conclusion: Single-dose praziquantel is still effective for the treatment of intestinal schistosomiasis. " 09/01/2019 - "Effect of nanoparticles on the therapeutic efficacy of praziquantel against Schistosoma mansoni infection in murine models."
2.	AntigensIBA 01/01/2018 - "Innovative methodology for point-of-care circulating cathodic antigen with rapid urine concentration for use in the field for detecting low Schistosoma mansoni infection and for control of cure with high accuracy." 10/01/2014 - "Combination of the two schistosomal antigens Sm14 and Sm29 elicits significant protection against experimental Schistosoma mansoni infection." 01/01/2023 - "It is worth mentioning that, to our knowledge, this was the first study using a multiepitope recombinant antigen in an ELISA for diagnosis of intestinal schistosomiasis, which demonstrated promising results in the diagnosis of individuals with low parasitic loads." 08/01/2014 - "The aim of present study was to evaluate the relative diagnostic performance of two urine-circulating cathodic antigen (CCA) cassette assays, one commercially available and the other in experimental production, against results obtained using the standard Kato-Katz faecal smear method (six thick smears from three consecutive days), as a 'gold-standard', for Schistosoma mansoni infection in different transmission settings in Uganda. " 01/01/2013 - "At baseline, all children were tested for intestinal schistosomiasis by microscopic examination of duplicate Kato-Katz smears prepared from a single stool faecal, by antigen detection with the urine CCA dipstick test and by serology with a commercially available ELISA test (as 'gold-standard') that measures host antibody titres to soluble egg antigens. "
3.	Oxamniquine FDA Link 01/01/1982 - "The authors conclude that oral oxamniquine in the prescribed dosage, has low toxicity and good therapeutic efficacy in children with chronic schistosomiasis mansoni." 01/01/1980 - "Therapeutic efficacy of oral oxamniquine in the toxemic form of schistosomiasis mansoni: treatment of eleven individuals from two families, and experimental study." 01/01/2000 - "IPraziquantel and oxamniquine both appear to be effective for the treatment of Schistosomiasis mansoni, although lower doses of oxamniquine (less than 30 milligrams per kilogram) may not be as effective." 01/01/1980 - "Serum levels and efficacy of oxamniquine in patients with Schistosomiasis mansoni following administration of a therapeutic dose." 01/01/1987 - "A double blind trial was set up to study the pulmonary effects of specific treatment with oxamniquine of 40 patients with chronic schistosomiasis mansoni. "
4.	VaccinesIBA 01/01/2018 - "The vaccine exhibited potent prophylactic efficacy against transmission of Schistosoma mansoni infection and was associated with significantly less egg-induced pathology, compared with unvaccinated control animals. " 12/01/2009 - "This study assessed the effectiveness of autoclaved cercarial vaccine (ACV) in protection against Schistosoma mansoni infection in 125 Swiss albino mice classified into two main groups: GI: a control group. " 08/01/1998 - "The efficacy of autoclaved cercarial vaccine (ACV) in eliciting protective immunity against Schistosoma mansoni infection was investigated in Swiss strain Albino mice. " 12/01/1978 - "Studies on putative adult worm-derived vaccines and adjuvants for protection against Schistosoma mansoni infection in mice." 01/01/2023 - "A randomized, controlled Phase 1b trial of the Sm-TSP-2 Vaccine for intestinal schistosomiasis in healthy Brazilian adults living in an endemic area."
5.	DNA (Deoxyribonucleic Acid)IBA 12/08/2003 - "Protection against Schistosoma mansoni infection in C57BL/6 female mice was evaluated by two DNA vaccination strategies. " 01/01/2020 - "The objective of this study was developed and to validate a real-time PCR assay (qPCR) targeting 121 bp sequence to detect Schistosoma spp. DNA for the diagnosis of intestinal schistosomiasis and a sequence of the human β-actin gene as internal control. " 11/01/2018 - "This work was carried out to investigate the possible effect of DNA vaccination against Schistosoma mansoni infection using recombinant S. " 09/01/2015 - "It is recommended to extract DNA from urine samples and to use the salting out and resin as a manual DNA extraction method from patients' samples for the molecular diagnosis of Schistosoma mansoni infection. " 01/08/2001 - "Immunostimulatory effect of IL-18-encoding plasmid in DNA vaccination against murine Schistosoma mansoni infection."
6.	EnzymesIBA 09/01/2000 - "Effect of Schistosoma mansoni infection and treatment on drug metabolizing enzymes." 03/01/1998 - "Different levels of Schistosoma mansoni infection induce changes in drug-metabolizing enzymes." 03/01/1995 - "An immunoprecipitation technique, ELIEDA (enzyme-linked-immuno-electro-diffusion assay), was evaluated for the diagnosis of Schistosoma mansoni infection with low worm burden. " 03/01/1995 - "Evaluation of the enzyme-linked-immuno-electro-diffusion-assay (ELIEDA) for the diagnosis of Schistosoma mansoni infection with low worm burden." 05/01/1979 - "[Serum enzymes in patients with schistosomiasis mansoni]."
7.	ArtesunateIBA 01/01/2000 - "Efficacy of artesunate against Schistosoma mansoni infections in Richard Toll, Senegal." 02/28/2004 - "Artesunate kills schistosomula and reduces the fecundity of females effectively, the infected mice do not develop schistosomiasis mansoni when treated with artesunate. " 01/01/1999 - "[Therapeutic evaluation of artesunate in experimental Schistosoma mansoni infection]." 02/28/2004 - "To study the prophylactic effect of artesunate against the infection of Schistosoma mansoni in mice and its optimal scheme for preventing schistosomiasis mansoni. " 04/01/2018 - "The present study was conducted to investigate the possible role of artesunate (AS) and praziquantel (PZQ) combination in enhancing cure in pre-patent and patent Schistosoma mansoni infection, and study the role of apoptosis in evaluation of the drugs efficacy. "
8.	ImmunosorbentsIBA 07/01/2005 - "Efficacy of an enzyme-linked immunosorbent assay as a diagnostic tool for schistosomiasis mansoni in individuals with low worm burden." 09/01/1997 - "Efficacy of an enzyme-linked immunosorbent assay in the diagnosis of and serologic distinction between acute and chronic Schistosoma mansoni infection." 11/01/2012 - "This study was conducted to assess two new parasite identification methods for diagnosing schistosomiasis mansoni in residents of a low endemic area in the municipality of Maranguape, in the state of Ceará, Brazil using the Kato-Katz method as a reference and serology (enzyme-linked immunosorbent assay) for the screening of patients. " 06/01/1978 - "Studies on the enzyme linked immunosorbent assay (ELISA) test for Schistosoma mansoni infections." 01/01/2007 - "We developed an enzyme linked-immunosorbent assay (ELISA) for serodiagnosis of Schistosoma mansoni infection using a purified immunogenic fraction from schistosome adult worm, obtained by SDS-polyacrylamid gel electrophoresis. "
9.	Monoclonal AntibodiesIBA 12/01/1982 - "Monoclonal antibody-mediated protection against Schistosoma mansoni infection in mice." 02/01/2013 - "Monoclonal antibody-based dipstick assay: a reliable field applicable technique for diagnosis of Schistosoma mansoni infection using human serum and urine samples." 01/01/1992 - "A group-specific monoclonal antibody was found to be suitable for detecting Schistosoma mansoni infection in Biomphalaria sp., but not for positive identification of S. " 12/01/1998 - "This study was undertaken to develop an immunodiagnostic test of active human schistosomiasis mansoni using a monoclonal antibody which targets urinary schistosomal antigen. " 05/04/1999 - "Induction of resistance against Schistosoma mansoni infection by passive transfer of an IgG2a monoclonal antibody."
10.	Immunoglobulins (Immunoglobulin)IBA 12/01/1998 - "This work was performed to study variations of Schistosoma specific immunoglobulins between early and chronic schistosomiasis mansoni in both children and adults. " 12/24/2021 - "Distinct Schistosoma mansoni-Specific Immunoglobulin Subclasses Are Induced by Different Schistosoma mansoni Stages-A Tool to Decipher Schistosoma mansoni Infection Stages." 01/01/2001 - "Schistosoma mansoni infection proceeds in normal mice in the absence of detectable levels of polyclonal or specific immunoglobulin (Ig)E until worms mature and deposit eggs. " 10/01/1996 - "Specific immunoglobulin measurements related to exposure and resistance to Schistosoma mansoni infection in Sudanese canal cleaners." 01/01/1979 - "Serum immunoglobulins in patients with schistosomiasis mansoni."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/1981 - "Stool examinations conducted on all study area residents during three years before chemotherapy showed the prevalence and intensity of Schistosoma mansoni infection to be high and stable. " 04/01/2019 - "mansoni eggs hatchability and viability, a ground for its use in chemotherapy of schistosomiasis mansoni and japonicum because of its increased bioavailability in the gastrointestinal tract. " 01/01/2018 - "Intestinal schistosomiasis due to Schistosoma mansoni was mapped in Cameroon in the 1990s and preventive chemotherapy launched since 2005. " 02/06/2017 - "Intestinal schistosomiasis in Uganda at high altitude (>1400 m): malacological and epidemiological surveys on Mount Elgon and in Fort Portal crater lakes reveal extra preventive chemotherapy needs." 07/01/2016 - "From a clinical perspective, MFS-LNCs offer potential as an alternative single oral dose nanomedicine with a wide therapeutic profile for the mass chemotherapy of schistosomiasis mansoni. "
2.	Aftercare (After-Treatment) 09/01/1997 - "Data obtained in the study of 359 serum samples from patients with Schistosoma mansoni infection, noninfected individuals, and patients followed-up for a period of 12 to 15 months after treatment provided the basis to postulate a general pattern for the kinetics of antibody decay. " 03/01/1989 - "Three study groups in the Rusizi plain (Burundi) were examined parasitologically (duplicate 28 mg Kato slides) and clinically (history, abdominal palpation) 0, 1.5, 3, 6, 12 and 24 months after treatment for Schistosoma mansoni infection. " 06/22/2020 - "Evaluation of serum-based real-time PCR to detect Schistosoma mansoni infection before and after treatment." 11/01/2015 - "We hypothesized that the (-G380A) polymorphism in the TNF-α gene is associated with regression of PPF after treatment for schistosomiasis mansoni. " 01/01/2015 - "In Schistosoma mansoni infection, diagnosis and control after treatment mainly rely on parasitological stool investigations which are laborious and have limited sensitivity. "
3.	Therapeutics 12/01/2023 - "Can antibody conjugated nanomicelles alter the prospect of antibody targeted therapy against schistosomiasis mansoni?" 01/01/2019 - "Prevalence and intensity of Schistosoma mansoni infection in pediatric populations on antiretroviral therapy in north-western Tanzania: a cross-sectional study." 01/01/2015 - "From a clinical point of view, data suggest MFS-LNCs as a potential single dose oral nanomedicine for enhanced therapy of schistosomiasis mansoni and possibly other diseases. " 11/01/2008 - "Clinical therapy of schistosomiasis mansoni: the Brazilian contribution." 01/15/2006 - "Symptomatic Schistosoma mansoni infection as an immune restoration phenomenon in a patient receiving antiretroviral therapy."
4.	Investigational Therapies (Experimental Therapy) 09/01/1974 - "[Experimental therapy of schistosomiasis mansoni. " 11/01/2013 - "According to the experimental studies, the deepest impression on the antischistosomal properties of mefloquine can be summarized as following points: (1) single dose of mefloquine possesses potential effect against three major species of schistosomes (Schistosoma mansoni, Schistosoma haematobium, and Schistosoma japonicum) infecting humans; (2) the drug displays similar effects against developing stages of juvenile and adult schistosomes, which are superior to that of artemisinins and praziquantel; (3) in vitro mefloquine exerts direct killing effect on juvenile and adult schistosomes, while in vivo, the efficacy of the drug is independent to host immune response, (4) mefloquine causes extensive and severe morphological, histopathological, and ultrastructural damage to adult and juvenile schistosomes, particularly, the worm tegument, musculature, gut, and vitelline glands of female worms are the key sites attacked by the drug; (5) combined treatment with mefloquine and praziquantel, or artemisinins shows synergistic effect against schistosome in experimental therapy,while in initially clinical trial, mefloquine in combination with artesunate also exhibits higher cure rates against schistosomiasis hematobia and schistosomiasis mansoni, and (6) several mefloquine-related arylmethanols exhibit potential effect against schistosomes in vivo, which is a useful clue helpful for development of new antischistosomal compound. "
5.	Oral Administration 11/01/2021 - "Efficacy of carvacryl acetate in vitro and following oral administration to mice harboring either prepatent or patent Schistosoma mansoni infections." 06/01/2021 - "The present study evaluated the effect of oral administration of five days celecoxib regimen (20 mg/kg/day) against different developmental stages of Schistosoma mansoni infection. "